Dipeptide-2

Noiʻi o Dipeptide-2

I loko o ka ʻepekema cosmetic, Hoʻonohonoho ʻia ʻo Dipeptide-2 ma ke ʻano he peptide bioactive me ka hiki ke kū i ka wā kahiko. Ua koi ʻia ka mālama ʻili anti-aging i nā peptides bioactive i mua o ka hoʻomohala hou; liʻiliʻi molecular kaumaha, ikaika (i kekahi wahi) hiki ke hoʻoholo, a me ka maikaʻi o ka ʻili permeability, kōkua lākou a pau i ko lākou kaulana. ʻO ka bioactivity kumu o dipeptide-2 iho mai ka angiotensin-converting enzyme (ACE) keakea waiwai. Hoʻokumu kēia i ke kumu kumu noʻonoʻo maikaʻi loa no kēlā me kēia pono cosmetic e hōʻike ʻia, ʻO ka pili ʻana i ka ʻili e pili ana i ka ʻili ʻo ia kekahi o nā noi pololei loa.

ʻO ka Angiotensin-Convert Enzyme (ACE) ʻO ia ka zinc metallopeptidase kī; ka hoʻololi ʻana o Angiotensin I i loko o ka vasoconstrictor ikaika ʻO Angiotensin II (ʻO ka ʻōnaehana renin-angiotensin ke kuleana no kēia kaʻina hana). ʻO Angiotensin II e like me ka mea i ʻōlelo ʻia, ke kumu o ka vasoconstriction, piʻi koko kiʻekiʻe, hiki ke paʻa i ka wai.

A 2015 Ua hoʻokaʻawale ʻia ka dipeptide-2 mai kahi iʻa kai hohonu pūmua hydrolyzate, e hōʻoiaʻiʻo ana i kona hiki ke pale i ka ACE – Ua hōʻike ʻia nā waiwai IC50, lawa haʻahaʻa e hōʻike i ka hana in vitro ikaika. Loaʻa ka hōʻike in vitro o kēia kaohi ACE kikoʻī.

E hōʻoia ana i ka hana pili ACE ma luna, Ua kuhikuhi pū ka haʻawina like i kāna mau waiwai antioxidant. ʻO ke kaumaha oxidative kahi ʻano extrinsic mua o ka ʻelemakule ʻili; ʻO nā ʻano oxygen reactive nui e hōʻino i nā ʻāpana kelepona āpau (DNA, nā polokina, lipids) a ho'ā i nā enzyme degradative o ka matrix extracellular. Val-Trp, ma ka hapa iki, pale i ke kino o ka ili mai keia ano poino – ʻO nā hopena anti-aging ʻano radical manuahi he mea hoʻohui waiwai i nā mea ʻē aʻe (a i palapala maikaʻi ʻia) pomaikai.

Ma ka hoʻokūkū ʻana i ka hana ACE, Hoʻemi ʻo Dipepetide-2 i ka hana ʻana o ka angiotensin II. Hoʻopau pololei ʻia ka Vasoconstriction a me ka edema kūloko e kēia hōʻemi.

He mea koʻikoʻi kēia mīkini i ka mālama ʻili; Hoʻohaʻahaʻa pono ʻia ka ACE inhibition i ka capillary permeability, ka pale ʻana i kekahi mau ʻano o ka hōʻiliʻili wai. ʻO ka hoʻomaikaʻi ʻana i ka wai lymphatic kahi hopena koʻikoʻi o kēia kaʻina hana, me ka puffiness periorbital a me nā ʻano hyperpigmentation e hoʻemi nui ʻia. ʻO ka microcirculation i hoʻonui ʻia e lawe mai i ka oxygen ʻoi aku ka maikaʻi a me ka hāʻawi ʻana i nā meaʻai maʻamau i nā ʻili ʻili – ola kino a kokoke i ke ola mau ka hopena.

Ke koi nei i kēlā dipeptide-2 (ma kahi ʻano mālama maka) hiki ke 'hoʻopau i nāʻeke maka, pōʻeleʻele, a me ka edema pili’ he kumu hoʻohana maikaʻi ia o kēia laina noʻonoʻo.

ʻO Dipeptide-2 kahi mea maʻamau i loko o ka mālama ʻili anti-aging premium, ʻo ka ʻaila maka ke kumu hoʻohālike. ʻO ka edema periorbital a me ka liʻiliʻi o kekahi mau hiʻohiʻona o nā pōʻeleʻele e hilinaʻi ʻia e ia. ʻO ka hoʻoikaika ʻana i ka pale ʻili a me ka hydration a puni ka mea hou, hōʻike maikaʻi nā pōmaikaʻi.

Kākoʻo nā haʻawina lāʻau lapaʻau i nā hoʻomaikaʻi āpau i ʻōlelo ʻia ma luna; ʻO ka paʻa a me ka ʻālohilohi nā helu hope o ka maikaʻi o ka lapaʻau.