Oligopeptide-2 bụ peptide bioactive - nwere mmasị dị ukwuu maka ngalaba ịchọ mma., A na-ejikarị eme ihe na ngwaahịa mgbochi ịka nká na mgbochi ịka nká.
Ọ dabere na iberi sitere na mpaghara C-terminal nke yinye collagen α1., na-etinye aka na njikọ nke collagen-laminin-integrin.
Iberibe peptide endogenous, Otú ọ dị, na-agbaji ngwa ngwa site protease n'elu akpụkpọ anụ, na-egbochi ntinye ya dị irè site na stratum corneum.
Nke a ewepụtala ọtụtụ usoro, Nke kachasị nke ọma bụ Oligopeptide-2.
A na-agbakwunye akụkụ palmitoyl iji mụbaa lipophilicity nke peptide, na-enyere aka ịbanye ya site na epidermal lipid bilayers ma si otú ahụ na-abawanye nkwụsi ike n'ozuzu maka nsonye na nhazi ihe ịchọ mma.
N'ihi ya, Oligopeptide-2 aghọwo ihe dị mkpa na ihe ịchọ mma kachasị mma.
Usoro
H-Lys-Thr-Thr-Lys-Ser-OH
Nọmba CAS
149128-48-3
Usoro ihe omimi
C23H45N7O9
Ibu molekụla
563.65
Nnyocha metụtara Oligopeptide-2
1.Usoro nke ime ihe na uru
Oligopeptide-2 na-enye aka fibroblast maturation, na-eme ka ụzọ mgbama intracellular dị ala, n'ụzọ dị ịrịba ama na-abawanye na njikọ ọzọ nke ụdị I na III collagens, rụọ ọrụ nke ọma na-akpali fibronectin na glycosaminoglycan mmepụta ma gosipụta ọrụ chemotactic, na-akwalite mbugharị fibroblast na mkpokọta na saịtị ebumnuche, si otú a na-eme ngwa ngwa mgbake anụ ahụ.
Na-aga n'ihu iji, Oligopeptide-2 na-ebelata omimi na njupụta nke wrinkles ihu, na-eme ka akpụkpọ anụ dịkwuo mma ma na-ewusi ọrụ mgbochi akpụkpọ ahụ ike.
2.Na-akwalite Synthesis Collagen
Oligopeptide-2 na-ejikọta na ndị na-anabata ya kpọmkwem na akpụkpọ anụ fibroblast, na-arụ ọrụ ụzọ mgbaàmà TGF-β.
Nke a na-eduga ná mmalite nke njikọ njikọ nke collagen mRNA, nke na-akwalite mmepụta nke intracellular nke ukwuu na ngwa ngwa precursor ụmụ irighiri ihe - maka ụdị I na III collagen.
A na-ahazikwa ihe ndị a ka ọ bụrụ netwọkụ zuru oke ma kwụsie ike - nke eriri collagen.
Nke a na-abawanye njupụta fiber collagen na ịdị mma, na-eme ka akpụkpọ ahụ dịkwuo mma na nkwụsi ike yana ibelata wrinkles.
3.Na-akpali mmepụta nke Fibronectin na Glycosaminoglycans, Na-akwalite hydration Skin
Na mgbakwunye na njikọ nke collagen, Oligopeptide-2 na-akpali mmepụta na ịgbalite fibronectin na glycosaminoglycans..
Ọ na-akwalite njikọ nke fibronectin na hyaluronic acid synthase, na-ebute matrix gel nke na-eme ka ikike ijide mmiri nke anụ ahụ dịkwuo mma.
N'ihi ya, akpụkpọ ahụ na-apụta na-agbakọta, juputara na mmiri juputara.
4.Mmetụta Chemotactic
Oligopeptide-2 nwere mmetụta chemotactic siri ike, na-eduzi fibroblasts na sel ndị mbụ ha ka ha kwaga n'ụzọ na-aga n'ebe akpụkpọ ahụ mebiri emebi.
Nke a na-ebuli ma na-emezi mmezi akpụkpọ ahụ ngwa ngwa, n'ịhụ na mweghachi dị elu nke anụ ahụ mebiri emebi.
COA
HPLC
MS
