Ko te Oligopeptide-2 he peptide koiora-he nui te hiahia mo te waahanga whakapaipai, whakamahia matua i roto i te anti-wrinkle me te anti-hoholo hua.
He mea hangai i runga i tetahi kongakonga mai i te rohe C-terminal o te mekameka collagen α1, whai wāhi ki te hononga whakawhiti collagen-laminin-integrin.
Ko te wahanga peptide endogenous, heoi ano, ka hohoro te wawahi e porotea i runga i te mata kiri, te aukati i tana urunga whai hua i roto i te stratum corneum.
Na tenei i whanau etahi pärönaki, ko te tino angitu o ko Oligopeptide-2.
Ka taapirihia he wahanga palmitoyl hei whakanui ake i te lipophility o te peptide, te whakaahuru i tana kuhu ma te epidermal nga taarua lipid me te whakanui ake i te pumau mo te whakauru ki roto i nga hanganga whakapaipai.
No reira, Ko te Oligopeptide-2 kua noho hei waahanga nui mo nga whakapaipai whakapaipai.
Raupapa
H-Lys-Thr-Thr-Lys-Ser-OH
Tau CAS
149128-48-3
Tātai rāpoi
C23H45N7O9
Taumaha rāpoi
563.65
Oligopeptide-2 Rangahau e pa ana
1.Te Mahi me nga Painga
Ko te Oligopeptide-2 e whakatairanga ana fibroblast pakeketanga, ka whakahohe i nga ara tohu intracellular o raro, tino whakanuia te whakahiato ano o momo I me III collagens, he pai te whakaongaonga fibronectin a glycosaminoglycan te whakaputa me te whakaatu i nga mahi chemotactic, te whakatairanga i te heke o te fibroblast me te whakahiato ki nga waahi whaainga, na reira ka tere te whakaora kiri.
Ma te whakamahi tonu, Ko te Oligopeptide-2 ka whakaiti i te hohonutanga me te kiato o nga weriweri kanohi, te whakapai ake i te kakano kiri me te whakapakari i te mahi arai kiri.
2.Ka whakatairanga i te Collagen Synthesis
Ko te Oligopeptide-2 e herea ana ki nga kaiwhiwhi motuhake i runga i nga kiriuhi fibroblast, te whakahohe te ara tohu tohu TGF-β.
Ko tenei ka arai ki te whakahohe o te collagen synthesis-hononga mRNA, e whakatairanga tino whai hua, me te tere hanga intracellular o tomua ngota ngota mo te momo I me III collagen.
Ka tukatukahia ano enei ki nga whatunga tino me te pumau o nga muka collagen.
Ma tenei ka piki ake te kiato me te kounga o te muka collagen, ka puta te pai ake o te kiri me te u me te whakaiti i nga kita.
3.Ka whakaihiihi i te hanga o te Fibronectin me te Glycosaminoglycans, Whakarei ake i te Hidration Kiri
I tua atu ki te whakahiato collagen, Ko te Oligopeptide-2 e whakaohooho ana i te hanga me te whakahohe o te fibronectin me te glycosaminoglycans..
Ka whakarei ake i te whakahiato fibronectin me te mahi synthase waikawa hyaluronic, ka puta he matrix gel e pai ake ai te kaha pupuri makuku o te kiri.
Ko te hua o te kiri ka ahua moma, ki tonu, ka nui ake te wai.
4.Pānga Chemotactic
Ko te Oligopeptide-2 he kaha nga ahuatanga chemotactic, te arahi i nga fibroblasts me o ratou pūtau mua ki te heke ki nga waahi kiri kua pakaru.
Ma tenei ka tino arotau me te whakatere i te whakatikatika kiri, te whakarite i te kounga teitei o te whakaora i nga kiko kua pakaru.
COA
HPLC
MS
