Tetrapeptide-26 (dzina la malonda Chronogen®) ndi tetrapeptide yoletsa kukalamba yopangidwa mwaluso yomwe yapangidwa mwaukadaulo biology ya maselo, ndi mfundo mapangidwe okhazikika m'munda wa epigenetics.
Mndandanda wake wa amino acid ndi H-Ser-Pro-Leu-Gln-NH2 ndipo kulemera kwake kwa molekyulu ndi pafupifupi 442.51 -443.49 Dalton.
Nthawi zambiri ndi ufa woyera wokhala ndi ukhondo wochuluka kwambiri 95% ku 98%, ndipo imakhala ndi kusungunuka kwabwino kwamadzi.
Monga zodzikongoletsera zogwira ntchito zimapangidwira kuti zithandizire khungu circadian rhythm, kuzipangitsa kuti zitetezedwe ku zisonkhezero zakunja masana ndikulimbikitsa kusinthika usiku.
Kutsatizana
Ser-Pro-Leu-Gln-NH2
Nambala ya CAS
1234463-61-6
Molecular Formula
Chithunzi cha C19H34N6O6
Kulemera kwa Maselo
442.51
Kafukufuku Wogwirizana ndi Tetrapeptide-26
1.Core Concept ndi Mechanism of Action
Monga amodzi mwa mayina amalonda a Tetrapeptide-26 ndi Chronogen®, dzina lomwe likuwonetsa machitidwe ake apakati pokhudzana ndi "nthawi" (Chrono) ndi kuwongolera ma jini - imagwira ntchito posintha mawonekedwe amtundu wa circadian rhythm wotchi yomwe imathandizira kuletsa kukalamba..
Kukhala mkulu chiyero synthetic peptide, nthawi zambiri amaphatikizidwa pamayendedwe otsata zopanga ndipo ziyenera kusungidwa pozizira, zouma komanso zotetezedwa ku kuwala kuti zikhalebe bata¹.
Ntchito yoletsa kukalamba ya Tetrapeptide-26 imapezedwa osati kudzera muzoletsa wamba kapena kuyambitsa njira zowonetsera koma kudzera munjira yobisika kwambiri ya epigenetic regulation., makamaka kutsata wotchi yamkati yama cell akhungu.
2.Circadian Rhythm Genes Modulation
Tetrapeptide-26 imathandizira kubwezeretsa luso lodzikonza nthawi yonse yausiku ndikukhalabe ndi mawonekedwe amtundu wamtundu wa circadian kuphatikiza WACHI, BMAL1 ndi PER1, zomwe zimasokonezedwa ndi ultraviolet (UV) kuwonongeka.
3.Kukonza DNA Thandizo
Peptide iyi imapangitsa kuti khungu lizitha kukonzanso kuwonongeka kwa DNA komwe kumachitika chifukwa cha kuwala kwa UV (monga maselo otenthedwa ndi dzuwa) ndikuwonjezera kaphatikizidwe ka ulusi wa collagen mkati mwa khungu kuti ukhale wokhazikika komanso wolimba ².
4.Anti-Photoaging
Tetrapeptide-26 imachepetsa zizindikiro za ukalamba monga makwinya, mizere yabwino, ndi kufooka pakhungu poletsa njira zama cell zokhudzana ndi kujambula zithunzi.
Tetrapeptide-26 imagwiritsidwa ntchito makamaka muzodzoladzola zoletsa kukalamba, monga ma seramu ausiku ndi ma ampoules, kupititsa patsogolo ntchito yokonza khungu pa nthawi ya kugona, potero kumawonjezera kulowetsedwa kwa zinthu ndi kuchita bwino.
Amapangidwa nthawi zambiri limodzi ndi ma peptides ena (Mwachitsanzo, Acetyl Tetrapeptide-9) kapena zopangira mbewu (mwachitsanzo, Albizia Julibrissin Bark Extract), kumene iwo synergistically ntchito kuchepetsa glycation-kuwononga komanso kuchepetsa zizindikiro zowoneka za kutopa, kupereka phindu loletsa kukalamba ³.
Tetrapeptide-26 imayimira njira yatsopano yothana ndi ukalamba yotengera ma epigenetic ndi circadian rhythms..
Ubwino wake waukulu ndikukwaniritsa khungu kutsitsimuka kudzera munjira zambiri zotsata (Kukonza DNA, kuwongolera kayimbidwe, collagen kaphatikizidwe).
Ngakhale maphunziro ambiri adachitidwa mu vitro kapena ngati mayeso oyambira azachipatala, ntchito yake mu zodzoladzola zatsimikiziridwa kale.
COA
Mtengo wa HPLC
MS
