Delta-inducing peptide (DSIP) ine biology inoshanda neuropeptide inoumbwa nemaamino acids mapfumbamwe. Kuwanikwa kweDSIP kwaimiririra shanduko mukunzwisisa kwemutemo wekurara-kubva pane yapfuura paradigm yepakati nuclei unilaterally inodzora kurara kusvika pakuzivikanwa kwebasa rinoitwa nevanodzora kurara kwekupedzisira..
Iyi peptide inoratidza akafara mabasa emuviri uye yakasarudzika nzira yekuita. Kugona kwayo kuyambuka nekukurumidza ropa-uropi chipingamupinyi(BBB) chimwe chezvinhu zvayo zvinozivikanwa; kubatanidzwa kwayo mukugadzirisa hypothalamic-pituitary-adrenal (HPA) axis uye pesvedzero pane systemic homeostasis zvese zvakanyatsonyorwa mhedzisiro.
Beyond ayo musimboti kurara-regulating mabasa (kusimudzirwa kwehope huru, kuvandudzika kwekurara, uye kuwedzera kunaka kwekurara), DSIP inoratidza yakasimba neuroprotective uye, kusvika pamwero unokosha, reparative kugona. Kuvandudza neuronal kuramba kune dzakasiyana siyana dzekuwedzeredza muenzaniso wakakosha weizvi.
Endocrine regulation uye thermoregulation zvakare akasimbiswa mabasa eDSIP. Munguva pfupi yapfuura, antioxidant uye detoxification mabasa akaonekwa.
Kutevedzana
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Nhamba yeCAS
62568-57-4
Molecular Formula
C35H48N10O15
Molecular Weight
848.33
Research Of Delta Kurara Inducing peptide (DSIP)
1.Migumisiro Inokonzera Kurara
Kurara kudzora ndiro basa rekutanga rinonyanya kubatanidzwa neDSIP. Kusimudzira kwakasimba uye kwakasarudzika kwe hope dzinononoka ndiwo maitiro ayo anogara achitaurwa. Traditional exogenous kurara aids inoshanda nenzira dzakasiyana zvachose; DSIP, se endogenous neuroregulatory peptide, physiologically modulates (nenzira inobvumirwa zvakanaka) chivakwa chekurara chemushandisi. Kuwedzera nguva yekurara kwakadzika ndiyo yakananga correlate yekuvandudzwa kwekurara.
Chidzidzo chinosanganisira 400 varwere vanorwara zvakanyanya kushaya hope, akagamuchira majekiseni eDSIP anoenderera kwevhiki, yakaratidza kuvandudzwa kwakakosha mune zvese zvakayerwa zvemhando yekurara. Varwere vane neurotic irritability, zvikuru sei, yakaratidza kuwedzera kwakajeka kwekugadziriswa kune kunze kwekusimudzira post-injection.
Mhedzisiro iyi inosimbisa basa rakasimba reDSIP mukuraira kwekurara uye kugona kwayo mukurapa kusagadzikana kwetsinga..
2.Muviri Tembiricha uye Motor Basa Regulation
Mimwe mishonga inowedzera huropi dopamine basa inogona kuchinja tembiricha yemuviri. DSIP inodyidzana nemishonga iyi, kukonzera shanduko dzambotaurwa.
Zvidzidzo mumakonzo zvakaratidza kuti madiki kusvika pakati nepakati madhisi eDSIP akadzikisa kuita kwemota uye tembiricha yemuviri pasi pe4 ° C mamiriro..
Apo mbeva dzakadzoserwa kunzvimbo ye22 ° C, DSIP kutungamirira kwakabatanidzwa nekuwedzera kwekushisa kwemuviri.
3.Endocrine Regulatory Basa
Iyo HPA axis ndiyo musimboti neuroendocrine system nekuda kwekunetseka kwemuviri.
Kuwedzeredza kweiyo system inotungamira kune isina kujairika, kusingaperi yakakwira cortisol mazinga. DSIP inopesana nemhedzisiro iyi nekuvharira CRH uye ACTH kuburitswa.
4.Neuroprotective uye Reparative Mabasa
DSIP yakaratidza neuroprotective uye reparative zvivakwa zvinomiririra chikamu chakakosha chekugona kwayo kurapa.
Inoratidza vimbiso yekurapwa kwe neurodegenerative zvirwere , pakati pemamwe mamiriro.
COA
HPLC
MS
