I-Oligopeptide-2 yi-peptide ye-bioactive inomdla ophezulu kwicandelo lezithambiso, isetyenziswa ikakhulu kwiimveliso ezichasene nemibimbi kunye nokuguga.
Isekwe kwiqhekeza kummandla we-C-terminal we-collagen α1 chain., inxaxheba kwi-collagen-laminin-integrin crosslinking.
Iqhekeza le peptide engapheliyo, nangona kunjalo, ichithwa ngokukhawuleza iiproteases kumphezulu wolusu, ukuthintela ukungena kwayo okusebenzayo nge i-stratum corneum.
Oku kuye kwavelisa inani le izinto eziphuma kuyo, eyona iphumeleleyo yi-Oligopeptide-2.
A palmitoyl moiety yongezwa ukwandisa lipophilicity yepeptide, ukwenza lula ukungena kwayo nge-epidermal lipid bilayer kwaye ngaloo ndlela kunyuswa uzinzo olupheleleyo lokubandakanywa kwimiqulu yezithambiso.
Ngenxa yoko, I-Oligopeptide-2 iye yaba yinto ebalulekileyo kwizinto zokuthambisa ezikumgangatho ophezulu.
Ulandelelwano
H-Lys-Thr-Thr-Lys-Ser-OH
Inombolo yeCAS
149128-48-3
Ifomula yeemolekyuli
I-C23H45N7O9
Ubunzima beMolekyuli
563.65
I-Oligopeptide-2 yoPhando oluNxulumeneyo
1.Indlela yokuSebenza kunye neeNzuzo
I-Oligopeptide-2 ibangela i-fibroblast ukukhula, ivula iindlela ezisezantsi zokubonisa i-intracellular, kwandisa ngokuphawulekayo i kwakhona synthesis yohlobo lwe-I kunye ne-III collagens, ivuselela ngokufanelekileyo i-fibronectin kwaye glycosaminoglycan imveliso kunye nokubonisa umsebenzi we-chemotactic, ukukhuthaza imfuduko yefibroblast kunye nokuhlanganiswa kwiindawo ekujoliswe kuzo, ngaloo ndlela kukhawulezisa ukuchacha kwesikhumba.
Ngokusetyenziswa okuqhubekayo, I-Oligopeptide-2 inciphisa ubunzulu kunye nokuxinana kwemibimbi yobuso, iphucula ukuthungwa kwesikhumba kwaye yomeleza umsebenzi wokuthintela ulusu.
2.Ikhuthaza i-Collagen Synthesis
I-Oligopeptide-2 ibophelela kwii-receptors ezithile kwiimbrane ze-fibroblast, iyasebenza indlela yomqondiso we-TGF-β.
Oku kukhokelela ekusebenzeni kwe-collagen synthesis-associated mRNA, ekhuthaza imveliso esebenzayo kunye nekhawulezayo ye-intracellular umanduleli iimolekyuli zohlobo I kunye ne-III collagen.
Ezi ziqhubekekiswa ngakumbi zibe ziinethiwekhi ezipheleleyo nezizinzileyo zemicu ye-collagen.
Oku kwandisa i-collagen fiber density kunye nomgangatho, okukhokelela ekuphuculeni ukuqina kwesikhumba kunye nokuqina kunye nokunciphisa imibimbi.
3.Ivuselela iMveliso yeFibronectin kunye neGlycosaminoglycans, Ukuphucula ukuKhuselwa koLusu
Ukongeza kwi-collagen synthesis, I-Oligopeptide-2 ivuselela imveliso kunye nokusebenza kwe-fibronectin kunye glycosaminoglycans.
Yongeza i-fibronectin synthesis kunye hyaluronic acid synthase umsebenzi, okukhokelela kwi-matrix yejeli ephucula amandla okugcina ukufuma kwesikhumba.
Ngenxa yoko, ulusu lubonakala luyi-plumper, igcwele kwaye igcwele amanzi amaninzi.
4.Isiphumo seChemotactic
I-Oligopeptide-2 ineempawu ezinamandla ze-chemotactic, Ukukhokela i-fibroblasts kunye neeseli zabo zangaphambili ukuba zifudukele kwicala elibhekiselele kwiindawo ezonakalisiweyo zolusu.
Oku kwandisa kakhulu kwaye kukhawulezise ukulungiswa kwesikhumba, ukuqinisekisa umgangatho ophezulu wokubuyiselwa kwezicubu ezonakalisiweyo.
I-COA
HPLC
NKSK
