Delta orun-inducing peptide (DSIP) ni a biologically lọwọ neuropeptide ti o ni awọn amino acids mẹsan. Awari ti DSIP ṣe aṣoju iyipada kan ninu oye ilana ilana oorun-lati apẹrẹ iṣaaju ti awọn arin aarin kan pato ti iṣakoso oorun si idanimọ ti ipa ti awọn olutọsọna oorun oorun ṣe..
peptide yii ṣe afihan awọn iṣẹ iṣe ti ẹkọ iṣe-ara ti o gbooro ati ilana iṣe ti o yatọ. Awọn oniwe-agbara lati nyara rekoja awọn idena-ọpọlọ ẹjẹ(BBB) jẹ ọkan ninu awọn ohun-ini akiyesi rẹ; awọn oniwe-ikopa ninu regulating awọn hypothalamic-pituitary-adrenal (HPA) ipo ati ipa lori eto eto homeostasis ti wa ni gbogbo daradara-ni akọsilẹ ipa.
Ni ikọja awọn iṣẹ iṣakoso oorun-mojuto rẹ (jin orun igbega, dara si orun faaji, ati imudara orun didara), DSIP displays strong neuroprotective and, to a significant extent, reparative capabilities. Improving neuronal resistance to various forms of overstimulation is a key example of this.
Endocrine regulation ati thermoregulation are also established activities of DSIP. More recently, antioxidant and detoxification activities have been observed.
Ọkọọkan
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Nọmba CAS
62568-57-4
Ilana molikula
C35H48N10O15
Òṣuwọn Molikula
848.33
Research Of Delta Sleep Inducing peptide (DSIP)
1.The Sleep-Inducing Effects
Sleep regulation is the primary function most commonly associated with DSIP. A potent and selective promotion of slow-wave sleep is its most consistently reported effect. Traditional exogenous sleep aids work through completely different mechanisms; DSIP, as an endogenous neuroregulatory peptide, physiologically modulates (in a well-tolerated manner) the user’s sleep architecture. Alekun iye akoko ti oorun jinlẹ jẹ ibamu taara ti didara oorun ti ilọsiwaju.
Iwadi kan ti o kan 400 awọn alaisan ti o ni ijiya pupọ insomnia, ti o gba awọn abẹrẹ DSIP lemọlemọfún fun ọsẹ kan, ṣe afihan awọn ilọsiwaju pataki ni gbogbo awọn abala wiwọn ti didara oorun. Awọn alaisan pẹlu irritability neurotic, gegebi bi, fihan ilosoke ti o samisi ni ibamu si awọn itara ita lẹhin abẹrẹ.
Awọn abajade wọnyi ṣe afihan ipa ti o lagbara ti DSIP ni ilana oorun ati agbara rẹ ni itọju awọn rudurudu ti iṣan.
2.Ara otutu ati Motor Išė Regulation
Awọn oogun kan ti o mu iṣẹ ṣiṣe dopamine ọpọlọ le yi iwọn otutu ara pada. DSIP ṣe ajọṣepọ pẹlu awọn oogun wọnyi, inducing awọn aforementioned ayipada.
Awọn ijinlẹ ninu awọn eku fihan pe awọn iwọn kekere si iwọntunwọnsi ti DSIP dinku iṣẹ-ṣiṣe mọto ati iwọn otutu ara labẹ awọn ipo 4°C.
Nigbati wọn da awọn eku pada si agbegbe 22°C, Isakoso DSIP ni nkan ṣe pẹlu ilosoke ninu iwọn otutu ara.
3.Endocrine Regulatory Išė
Iwọn HPA jẹ mojuto eto neuroendocrine fun idahun wahala ti ara.
Overactivation ti yi eto nyorisi si ajeji, awọn ipele cortisol ti o ga pupọ. DSIP ṣe atako ipa yii nipa didi CRH ati itusilẹ ACTH.
4.Neuroprotective ati Awọn iṣẹ atunṣe
DSIP ti ṣe afihan neuroprotective ati awọn ohun-ini atunṣe ti o ṣe aṣoju abala pataki ti agbara itọju ailera rẹ.
O fihan ileri fun itọju ti neurodegenerative arun , laarin awọn ipo miiran.
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