I-AHK iyi-tripeptide eyakhiwe ngama-amino acid amathathu: i-anine (Ala), i-histidine (Okwakhe) futhi i-lysine (Lys).
Le peptide encane inhle kakhulu transdermal ukumuncwa.
Kukholelwa ukuthi ngenxa yama-amino acid anamaqembu anikela nge-electron, njenge-histidine ne-lysine ebonakala esakhiweni sayo, ingasusa ama-radicals mahhala futhi ivikele i-lipids kuwo i-peroxidation futhi zikhandle i-antioxidant imisebenzi.
Kokubili ukuhlanganiswa kwamakhemikhali kanye ukuzihlukanisa ukusuka i-proteolysate amaprotheni emvelo (isib., izinhlanzi zasolwandle, amaprotheni obisi) manje kungenzeka ukukhiqiza i-AHK.
Ngokuphambene neningi le i-macromolecular ama-antioxidants, I-AHK inesisindo samangqamuzana esiphansi kakhulu futhi esingcono i-biocompatibility, engase ifaneleke kakhulu njengesimonyo esisebenzayo.
Ukulandelana
Ala-His-Ls
Inombolo ye-CAS
126828-32-8
I-Molecular Formula
I-C15H26N6O4
Isisindo samangqamuzana
354.40
Ucwaningo Oluhlobene ne-AHK
Babethanda ikakhulukazi umsebenzi we-antioxidant futhi bahlongoza lokho: Umphumela oyinhloko we-AHK ungenxa yemisebenzi yayo ye-antioxidative, ezikhiqizwa ukulandelana kwezenzo ezilandelayo:
1.Ukuphanga I-ROS
I-ROS ingesinye sezizathu ezibaluleke kakhulu zokubangela i-oxidation yamaselula nokuguga esikhumbeni..
Ukudluliswa okuqondile kwe ama-electron noma ama-athomu e-hydrogen ukukhulula ama-radicals ngokwabo ukuze kusebenze i-ROS ngama-peptide amaningi e-antioxidant, kubangela ukuqedwa kwe-ROS.
I i-histidine futhi i-lysine izinsalela ze-AHK zinganikela ngama-athomu e-hydrogen noma ama-electron ukuze kucishwe ama-radicals e-ROS (I-DPPH, I-ABTS) ngokuqondile ukuqeda i-oxidative ukusabela kweketanga.
Kuye kwabikwa ukuthi ama-peptide aqukethe i-histidine angabulala ama-radicals ngokusebenzisa SET (I-Single Electron Transfer) noma ISIGQABA (I-Hydrogen Atom Transfer) inqubo.
2.Ukusebenza kwe-Endogenous Antioxidant Systems
Amanye ama-peptide e-antioxidant akhuphula amandla e-cell anti-oxidative ngokuvuselela ama-anti-oxidase abalulekile e-intracellular. (isib., I-superoxide dismutase SOD, i-glutathione peroxidase GSH-Px)².
Kwamanye amamodeli weselula, I-AHK-type peptides ingathuthukisa ukubonakaliswa kwama-enzyme e-antioxidant angapheli njenge-SOD ne-GSH-Px, okungase kube lula ukuzivikela kwamaselula ngokumelene ukucindezeleka kwe-oxidative.
3.I-Metal Ion I-Chelation
I imidazole indandatho ye-histidine kanye neqembu le-amino le-lysine lingakwazi ukuhlanganisa inguquko metal ions (njenge-Fe²⁺, Ku²⁺), okuzokwenza attenuated metal-catalyzed I-Fenton reactivity, ngaleyo ndlela kuholele ekuvinjweni i-hydroxyl radical ukwakheka ⁴.
I-copper ion yayo eyinkimbinkimbi (I-AHK-Cu, eyaziwa ngokuthi I-GHK-Cu noma ithusi tripeptide-1) –esikhundleni se-AHK yedwa– inokusetshenziswa okusungulwe futhi okwaziwa kakhudlwana kuzimonyo.
Izinzuzo ezithathwe ku-antioxidant, ukufakwa kabusha kwe-collagen nokulungiswa ngokushesha, I-AHK isetshenziswe kumafomu emikhiqizo ehlukahlukene ye-skincare.
4.Kunoma iyiphi imikhiqizo ye-serum nekhilimu elwa nokuguga
Ukuqinisa isikhumba esixegayo kanye nokunciphisa imibimbi ngokukhuthaza syntonyization ye-collagen & ukulwa nokucindezeleka okwenziwe nge-oxidative.
5.Okwezimonyo zangemuva kokuhlinzwa noma zokulungisa amanxeba
Ukukhuthaza izinqubo zokulungisa i-epidermial kuyilapho kufinyezwa ubude besikhathi sokuphola.
Izimonyo zokunakekelwa kwesikhumba nezinwele: Izifundo zafakazela amakhono ayo okukhangisa i-angiogenesis nxazonke i-follicle yezinwele ukufeza ukukhula kwezinwele& okwenza kube khona ama-shampoos alwa nokulahlekelwa noma ama-serum okukhula.
Ngaphezu kwalokho, ekwakhekeni kwe-antioxidant, I-AHK inamandla okwengeza izinzuzo ezithakweni ezifana noVithamini C no-E, ukuthuthukisa umphumela wenethiwekhi okhethekile we-anti-oxidant we-skincare ongathuthukisa ukuzivikela*1 kanye nokulungisa imisebenzi esikhumbeni..
I-COA
I-HPLC
MS
