Name: DSIP
SKU: 198623
Availability: InStock

I-peptide ye-Delta ebangela ukulala (I-DSIP) iyasebenza ngokwebhayoloji i-neuropeptide yakhiwe ngama-amino acid ayisishiyagalolunye. Ukutholakala kwe-DSIP kumelele ushintsho ekuqondeni ukulawula ukulala—kusuka kupharadigm yangaphambilini ye-nuclei ethile emaphakathi elawula ukulala ngokuhlangene kuya ekubonweni kwendima edlalwa izilawuli zokulala ezingapheli..

Le peptide ibonisa imisebenzi ebanzi yomzimba kanye nendlela ehlukile yokwenza. Ikhono layo lokuwela ngokushesha umgoqo wegazi-ubuchopho(BBB) ingenye yezindawo zayo eziphawulekayo; ukubamba iqhaza kwayo ekulawuleni i-hypothalamic-pituitary-adrenal (I-HPA) i-eksisi kanye nomthelela ku-systemic i-homeostasis yonke imiphumela ebhalwe kahle.

Ngale kwemisebenzi yayo ewumongo yokulawula ukulala (ukukhuthazwa kokulala okujulile, ngcono ukulala izakhiwo, kanye nekhwalithi yokulala ethuthukisiwe), I-DSIP ibonisa i-neuroprotective eqinile kanye, ngokwezinga elibalulekile, amakhono okulungisa. Ukuthuthukisa ukumelana ne-neuronal ezinhlotsheni ezihlukahlukene zokuvuselela ngokweqile kuyisibonelo esiyinhloko salokhu.

Ukulawulwa kwe-Endocrine futhi i-thermoregulation nazo ziyimisebenzi esunguliwe ye-DSIP. Muva nje, i-antioxidant futhi ukukhipha ubuthi imisebenzi iye yabonwa.

Ukulandelana

Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

Inombolo ye-CAS

62568-57-4

I-Molecular Formula

I-C35H48N10O15

Isisindo samangqamuzana

848.33

Ucwaningo Lwe I-Delta Sleep Inducing peptide (I-DSIP)

1.Imiphumela Ebangela Ukulala

Ukulawulwa kokulala kuwumsebenzi oyinhloko ovame ukuhlotshaniswa ne-DSIP. Iphromoshini enamandla futhi ekhethiwe ye ukulala okuhamba kancane umphumela wayo obikwa njalo. Izinsiza zokulala zendabuko zangaphandle zisebenza ngezindlela ezihluke ngokuphelele; I-DSIP, njenge-peptide engapheli ye-neuroregulatory, i-physiologically modulates (ngendlela ebekezeleleke kahle) isakhiwo sokulala somsebenzisi. Ukwandisa ubude besikhathi sokulala okujulile kuwukuhlobana okuqondile kwekhwalithi yokulala ethuthukisiwe.

Ucwaningo olubandakanya 400 iziguli ezihlushwa kanzima ukuqwasha, owathola imijovo ye-DSIP eqhubekayo isonto lonke, ibonise ukuthuthuka okuphawulekayo kuzo zonke izici ezilinganiselwe zekhwalithi yokulala. Iziguli ezinokucasuka kwe-neurotic, ngokuqondene, ibonise ukwenyuka okuphawulekayo kokuvumelana nezisusa zangaphandle zokujova ngemva komjovo.

Le miphumela igcizelela indima enamandla ye-DSIP ekulawulweni kokulala namandla ayo ekwelapheni ukuphazamiseka kwemizwa..

2.Ukulawulwa Kwezinga Lokushisa Lomzimba kanye Nemisebenzi Yezimoto

Izidakamizwa ezithile ezithuthukisa ukusebenza kwe-dopamine yobuchopho zingashintsha izinga lokushisa lomzimba. I-DSIP isebenzisana nale mithi, ukukhuthaza izinguquko ezishiwo ngenhla.

Ucwaningo kumagundane lubonise ukuthi imithamo emincane ukuya komaphakathi ye-DSIP yehlisa ukusebenza kwemoto kanye nezinga lokushisa lomzimba ngaphansi kwezimo ezingu-4°C.

Lapho amagundane ebuyiselwa endaweni engu-22°C, Ukuphathwa kwe-DSIP kwakuhlotshaniswa nokwenyuka kwezinga lokushisa lomzimba.

3.Umsebenzi Wokulawula I-Endocrine

I-axis ye-HPA iwumgogodla uhlelo lwe-neuroendocrine impendulo yokucindezeleka komzimba.

Ukusebenza ngokweqile kwalolu hlelo kuholela kokungajwayelekile, amazinga e-cortisol aphakeme njalo. I-DSIP iphikisana nalo mphumela ngokuvimbela ukukhishwa kwe-CRH ne-ACTH.

4.Imisebenzi ye-Neuroprotective ne-Reparative

I-DSIP ibonise izakhiwo ze-neuroprotective nezilungisayo ezimele isici esibalulekile samandla ayo okwelapha.

Ibonisa isithembiso sokwelashwa kwe izifo ze-neurodegenerative , phakathi kwezinye izimo.

I-COA

I-HPLC

MS

(1) I-Graf, M. V.; phonsa, A. J. I-peptide ye-Delta-eyenga ukulala (I-DSIP): Isibuyekezo. Isayensi yezinzwa & Ukubuyekezwa kwe-Biobehavioral 1984, 8 (1), 83-93. I-DOI: 10.1016/0149-7634(84)90022-8.

(2) Schneider Helmert, D. Imiphumela ye-DSIP ku-Narcolepsy. I-European Neurology 1984, 23 (5), 353-357. I-DOI: 10.1159/000115713.

(3) Schneider Helmert, D. I-DSIP ku-Insomnia. I-European Neurology 1984, 23 (5), 358-363. I-DOI: 10.1159/000115714.

(4) Yehuda, S.; phonsa, A. J.; Coy, D. H. Imiphumela ye-Thermoregulatory kanye ne-locomotor ye-DSIP: Ukusebenzisana okuyindida ne-d-amphetamine. I-Pharmacology Biochemistry kanye nokuziphatha 1980, 13 (6), 895-900. I-DOI: 10.1016/0091-3057(80)90225-7.

(5) Iyer, K. S.; McCann, S. M. I-Delta Sleep Inducing Peptide Inhibits Somatostatin Release nge-Dopaminergic Mechanism<sup>1</sup>. I-Neuroendocrinology 1987, 46 (1), 93-95. I-DOI: 10.1159/000124802.

(6) UQuinn, J. P.; Ethier, E. C.; Novielli, A.; Malone, A.; Ramirez, C. E.; I-Salloum, L.; Icilongo, B. A.; Isaka letshe, P.; Bremen, M.; Selzer, S.; et al. I-Cerebrospinal Fluid kanye ne-Brain Proteoforms ye-Granin Neuropeptide Family in Alzheimer's Disease. Ijenali ye-American Society for Mass Spectrometry 2023, 34 (4), 649-667. I-DOI: 10.1021/jasms.2c00341.

ukucaciswa	10 mg, 2 mg, 5 mg

Imikhiqizo

Izindaba

I-DSIP