About MOL Changes
MOL Changes is a peptide-focused biotechnology company based in Changsha, Hunan, China. We provide custom peptide synthesis from milligram to kilogram scale, peptide modification, purification, analytical testing and peptide CRO services for biopharmaceutical, academic and cosmetic organisations worldwide.
Who we are
MOL Changes is the operating brand of Cambrian Life Sciences HK Limited. The brand is what customers work with day to day: the synthesis team, the analytical laboratory, the project managers and the documentation that accompanies each batch. Cambrian Life Sciences HK Limited is the legal entity behind the brand. Contracts, invoices and formal quality documents are issued in the legal name, while the technical work is delivered under the MOL Changes brand. Stating the relationship plainly matters, because a buyer should never have to guess which company is responsible for a batch.
Where we work
Our laboratory and production site is at No. 58, Airport Avenue, Changsha, Hunan, China. Changsha is a well-connected inland hub with direct air freight to Europe, North America and Asia, which keeps transit times predictable for temperature-sensitive shipments. Customers are welcome to request a site visit or a remote audit; both are scheduled through the contact form.
What we make
The core service is custom peptide synthesis. Most projects are built by solid-phase peptide synthesis, with liquid-phase and hybrid routes used when sequence length, hydrophobicity or quantity make them the better choice. Scales range from milligram screening lots to kilogram campaigns. Beyond the linear sequence, we run cyclisation, stapling, PEGylation, biotinylation, fluorescent and isotope labelling, phosphorylation, glycosylation and click-chemistry handles.
Analytical release testing is performed in-house by reverse-phase HPLC and electrospray LC-MS, with MS/MS sequencing, amino-acid analysis and net-peptide-content determination available when a project needs them. Peptide CRO projects combine synthesis, modification and testing under a single specification, which shortens the hand-off between chemistry and analysis.
Facilities and analytical capability
The site houses synthesis reactors at multiple scales, preparative HPLC for purification, lyophilisation equipment and an analytical laboratory for release testing. Peptides are purified on reverse-phase gradients selected for the sequence rather than a single fixed method, because a gradient that resolves one peptide can co-elute another. Lyophilised product is packed under controlled humidity with desiccant, and solution products are prepared when a project requires them.
Quality system
Every released batch is linked to a batch record, and every certificate of analysis reports the batch number, sequence, appearance, HPLC purity, observed and theoretical mass, and the method used for each result. Deviations are recorded and resolved before release. We do not claim certifications we do not hold: if your programme requires a specific certificate, audit report or regulatory document, state it during the quotation and we will confirm what can be provided before the batch is scheduled.
Who we serve
Our customers include biopharmaceutical discovery groups, academic laboratories, diagnostic developers and cosmetic ingredient formulators. Each group needs a different documentation package. A research laboratory usually needs a certificate of analysis and a sequence; a diagnostic developer needs a stable specification and change control; a cosmetic formulator needs ingredient identity and purity documentation for the destination market. Defining that package at quotation avoids surprises at delivery.
How we work
A project starts with a feasibility review of the sequence and the requested modification. We flag aggregation-prone motifs, multiple cysteines, difficult couplings and solubility risks before quoting. The quotation fixes the quantity, purity target, salt form, delivery form, analytical tests and lead time. Synthesis begins after the specification is approved, and the batch is released only when the analytical results meet the agreed criteria. Shipping is arranged with the documentation required for the destination.
Verify us
We would rather be verified than described. Ask for a sample certificate of analysis, request the analytical method behind a purity value, or send a blinded sample for independent testing. If a claim on this site cannot be supported by a document, it should not be relied on. For quotations, technical feasibility reviews and documentation requests, contact [email protected] or use the quotation form.
Frequently asked questions
Is MOL Changes the same company as Cambrian Life Sciences HK Limited?
MOL Changes is the operating brand; Cambrian Life Sciences HK Limited is the legal entity. Contracts and formal quality documents use the legal name, while technical work and customer communication use the MOL Changes brand.
Where is the laboratory located?
The laboratory and production site is at No. 58, Airport Avenue, Changsha, Hunan, China. Site visits and remote audits can be arranged through the contact form.
Can I audit the quality system before placing an order?
Yes. We answer supplier questionnaires and can walk through one real batch record, the release methods and the deviation process. Requests that involve confidential supplier information are handled under a mutual confidentiality agreement.
What is the best way to start a project?
Send the sequence or target description, the required modification, quantity, purity target, delivery form and any documentation requirements. A feasibility review and quotation follow, normally within two business days.
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