Acetyl Tripeptide-1 ndi peptide yokonzekera yopangira, kupangidwa kudzera pa N-terminal acetylation (Kusintha kwa "capping".) za tripeptide yopezeka mwachilengedwe GHK yomwe imapezeka mkati plasma ndipo ili ndi kapangidwe kake kake kofanana ndi Acetylated Polypeptide-1. Kusintha kumeneku kumathana ndi zovuta zomwe tafotokozazi za GHK yoyambirira, kuphatikizapo kusakhazikika chifukwa cha aminoxidases, inactivation mu zodzoladzola formulations, ndi theka la moyo lalifupi.
Powombetsa mkota, Acetyl Tripeptide-1 imachepetsa bwino mizere yabwino ndi makwinya, imalimbitsa khungu, ndi kuyeretsa khungu. Ndi mankhwala oletsa kukalamba omwe ali ndi ndondomeko yomveka bwino, mwatsatanetsatane, ndi kusonyeza mphamvu.
Kutsatizana
Ac-Gly-His-Ls-OH
Nambala ya CAS
350595-76-5
Molecular Formula
C16H26N6O5
Kulemera kwa Maselo
382.42
Kafukufuku Wogwirizana ndi Acetyl Tripeptide-1
1.Core Mechanisms ndi Multifaceted Effects
Ziwonetsero za GHK za acetylated zawonjezeka hydrophobicity ndi theka la moyo wautali ndikusunga Cu²⁺ yake yosinthika-chelation katundu. Zinthu izi zimathandizira kupanga mapangidwe a copper-peptide mkati mwa dermal layer, kumawonjezera mphamvu popanda kuwonjezera cytotoxicity.
Imagwira pa dermal fibroblast maselo kuti athane ndi ukalamba wochititsidwa ndi nthawi kapena chilengedwe. Kupyolera mu kumangiriza ku ma cell enieni olandirira, imayambitsa ma intracellular signing cascades kuti asinthe magwiridwe antchito a ma genetic.
Imalimbikitsa kwambiri kaphatikizidwe ndi katulutsidwe ka Mtundu Woyamba & III collagen ndi elastin, chifukwa cha deser, khungu lakuda. Izi, panthawi yake, amachepetsa makwinya, kufooka, ndi kuphulika chifukwa cha kutayika kwa collagen.
Zimalepheretsanso ntchito yowonjezereka ya matrix metalloproteinase, kukhazikitsa microenvironment yoteteza khungu yomwe imachepetsa kuwonongeka kwa matrix amtundu wa extracellular.
2.Imalimbikitsa Collagen ndi Elastin Synthesis
Acetyl Tripeptide-1 imafika pachimake pakhungu, kumene imagwira ntchito ngati a ligandi kwa ma receptor apadera pa membrane ya cell ya fibroblast. Kumanga uku kumagwira ntchito protein kinase yopangidwa ndi mitogen (MAPK) ndi phosphoinositide 3-kinase (Chithunzi cha PI3K) njira zowonetsera, kulimbikitsa kukula kwa fibroblast ndikuwongolera anabolic metabolism.
Pa zolembedwa mlingo, imathandizira kafotokozedwe ndi kaphatikizidwe ka collagen ya Type I, Mtundu III wa collagen, ndi elastin, potero kuwonjezera ndende yawo ndi kachulukidwe mu khungu. Izi zimatsogolera ku plumper, kwambiri voluminized khungu. ¹
3.Amaletsa Mopambanitsa Matrix Metalloproteinase Kufotokozera
Acetyl Tripeptide-1 imasintha ma signature kuti achepetse kuchuluka kwa matrix metalloproteinases. (MMPs), komanso kuchepetsa kupitilira extracellular matrix kuwonongeka mwa kupondereza kaphatikizidwe kawo pamlingo wa transcriptional.
Kusunga collagen yomwe ilipo kudzera m'makinawa kumathandiza kusunga makulidwe a dermal ndi kukhulupirika, kumawonjezera nthawi yotulutsa collagen, ndipo motero zimathandiza kuchedwetsa ukalamba. ²,³
4.Imakulitsa Ntchito Yokonza Khungu Lama Cellular
Acetyl Tripeptide-1 imayendetsa njira ya PI3K/Akt, chowongolera chachikulu cha kupulumuka kwa ma cell, kukula, ndi metabolism. Kukondoweza uku kumawonjezera ntchito za fibroblast ndikuwonjezera kukonzanso kwa microtrauma ya tsiku ndi tsiku.
Komanso scavenges ma free radicals opangidwa kudzera zitsulo-ion catalysis, potero kuteteza m'njira zina kupsinjika kwa okosijeni-kuchititsa kuwonongeka kwa ma cell ndikulimbikitsa khungu lathanzi. ⁴
COA
Mtengo wa HPLC
MS
