Hexapeptide-9 (Hexapeptide-9, dzina la malonda Collaxyl™) ndi peptide yopangidwa ndi bioactive yopangidwa ndi ma amino acid asanu ndi limodzi. Mapangidwe enieni a peptide iyi amapezeka mkati mwa collagen IV ndi XVII yamunthu; izi zikugwirizana kwambiri ndi zigawo zikuluzikulu za khungu la pansi pa khungu. Biotechnologically synthesized kutengera ena, ngati si onse, ntchito za collagen zachilengedwe, chiyero ndi kukhazikika nkhani zomwe zimachokera ku 'chikhalidwe’ zotulutsa zachilengedwe zimathetsedwa. Kukhazikika kwapamwamba komanso kupangika kosavuta kwapangitsa kuti ayambe kutengera zinthu zosiyanasiyana zoletsa kukalamba..
Kutsatizana
Gly-Pro-Gln-Gly-Pro-Gln
Nambala ya CAS
1228371-11-6
Molecular Formula
C₂₄H₃₈N₈O₉
Kulemera kwa Maselo
582.28 g/mol
Kafukufuku wa Hexapeptide-9
Njira zingapo zochitira zinthu zolembedwa za Hexapeptide-9. Njira yoyamba yotumizira mauthenga achilengedwe imagwiritsidwa ntchito – kuyambitsa ndikuwongolera kaphatikizidwe kakhungu ndi kukonza njira.
Kulimbikitsa Collagen Synthesis: Kukondoweza mwachindunji kwa dermal fibroblasts ndi njira imodzi yotere; kuchulukitsidwa kwa ma collagen a Type I ndi Type IV kukhala zotsatira zomaliza. Type I imagwira ntchito ngati chithandizo chapafupi chokhazikika chomwe chimapezeka mu dermis, kupirira kukhala chinthu chochokera mwachindunji. Mtundu IV (mwana wa collagen’ ngati mungatero) kumapangitsa kuti khungu likhale losalala komanso losalala kwambiri.
Kukwezeka kwapawiri kwa ma collagen onsewa kumabweretsa kukonzanso koyenera kwa kapangidwe ka khungu., kuchepetsa kuya kwa makwinya ndi kuwongolera kozungulira kolimba.
Kulimbikitsa Dermal-epidermal Junction(MADZI): Apa ndipamene Hexapeptide-9 imadzipatula yokha. Chithunzi cha DEJ (kachiwiri, mlatho wakuthupi) imabwezeretsedwa pang'ono ndi izo. Laminin-5 ndi Type IV collagen kaphatikizidwe m'derali ndizomwe zimapangitsa Hexapeptide-9 kukhala yofunika kwambiri kwa ogwiritsa ntchito..
Kusamutsa zakudya, umphumphu wa kamangidwe ndi zonse zotsatira, kulimbana kosalekeza ndi nthawi ndi kugwa.
Kulimbikitsa Skin Barrier ndi Hydration: Pamwamba pa zochita zake za dermal, Hexapeptide-9 imathandizira kukonzanso epidermal. Kubwezeretsa khungu lowonongeka (zizindikiro za post-acne, mitundu yosiyanasiyana ya zokala, kapena zotsatira zina za pambuyo pa zokongoletsa) ndi imodzi mwazofunikira kwambiri.
Kafukufuku wa in vitro efficacy adawonetsa makamaka kuwongolera kwa filaggrin (Mtengo wa FLG) jini; Kusiyanitsa kwa epidermal ndi ntchito yotchinga pambuyo pake kumadalira kwambiri mapuloteniwa. Filaggrin palokha ndi kalambulabwalo wa zomwe zimadziwika kuti Natural Moisturizing Factors – kuchuluka kwa kupezeka kukhala chizindikiro chachindunji cha nthawi yayitali komanso yayitali pakhungu, pafupi ndi mapeto angwiro a chitetezo chotchinga.
Maphunziro azachipatala awonetsa kuwonjezeka kwa kupanga kolajeni kwathunthu (mpaka 117% ngati ndikukumbukira bwino) ndi kuwongolera kowoneka bwino koma koyezeka mu elasticity.
Komanso, Kafukufuku tsopano akulozera ku cyclic hexapeptide-9 (CHP-9) ngati njira yabwino kwambiri yothanirana ndi ukalamba. Ma peptides amtundu wachikhalidwe ali ndi malo awo, koma mawonekedwe a cyclic amapereka kukhazikika kwakukulu, kuwonjezereka kwa bioavailability ndi zochitika zonse za thupi.
Kugwiritsa ntchito pamutu kwa mtundu wina wa cyclic peptide iyi ndi njira yabwino kwambiri yopewera kapena kuchepetsa kukalamba kwa khungu.. Kutsimikizira zabwino zonse zomwe zatchulidwa pamwambapa kudzera mu maphunziro oyendetsedwa bwino ndi sitepe yotsatira yomveka.
COA
Mtengo wa HPLC
MS
