Myristoyl Pentapeptide-4 ndi biofunctional peptide yomwe imathandizira kuti khungu likhale lodzaza, kukhazikika, ndi mawonekedwe aunyamata.
Idapangidwa motengera kutengera komanso kumvetsetsa kwanzeru insulin-ngati kukula factor-1 (IGF-1) ndi udindo wake pakuwongolera kuchuluka kwa maselo, kusiyana, apoptosis ndi kaphatikizidwe wa extracellular matrix zinthu monga collagen ndi elastin.
IGF-1 siyoyenera kugwiritsidwa ntchito zodzikongoletsera chifukwa cha kulemera kwake kwakukulu komwe kumalepheretsa kulowa mkati mwa khungu., kusakhazikika bwino komanso kukwera mtengo. Poyang'ana madera ovuta a receptor a IGF-1, kutsata kwapakati kwa Lys-Thr-Thr-Lys-Ser kudadziwika.
Imawonetsanso kulolerana kwabwino pakhungu lovuta ndipo motero yakhala yofunika kwambiri pakupanga mankhwala odana ndi ukalamba a dermatological formulations..
Kutsatizana
Lys-Thr-Thr-Lys-Ser (KTTKS)
Nambala ya CAS
1392416-25-9
Molecular Formula
C37H71N7O10
Kulemera kwa Maselo
774.00
Myristoyl Pentapeptide-4 Related Research
1.Core Mechanism ndi Zoyambira Zoyambira
N-terminal myristoylation kwambiri bwino ake lipophilicity ndi kutulutsa khungu, kupangitsa peptide kumangiriza mwachindunji ku IGF-1 zolandilira ndikuyambitsa siginecha yakumunsi.
Izi, panthawi yake, imadzutsanso kuchepa kwa zaka zokhudzana ndi zaka za anabolic cutaneous process; imayang'anira kuchuluka kwa kaphatikizidwe kamitundu yosiyanasiyana yamapuloteni amtundu wa extracellular monga Type I collagen, Type III collagen ndi elastin – mwachangu kubwezeretsa kuwonongeka kwa dermal cell chifukwa cha ukalamba.
Izi zimakulitsa kwambiri kachulukidwe ndi makulidwe a minofu ya dermal, kuwonetsa kuthekera kwakukulu kochepetsera kapena kufufuta makwinya osasunthika.
2.Imathandizira kaphatikizidwe ka Collagen I ndi III
Mtundu wa Collagen I ndi III ndi mapuloteni ofunikira kwambiri pakhungu komanso kulimba.
Kuthekera kwawo kwachilengedwe kumachepa kwambiri ndi zaka.
Myristoyl Pentapeptide-4 imagwira ntchito potengera chizindikiro cha IGF-1, kumangiriza ku insulin-ngati kukula factor-1 receptor ndikuyambitsa mayankho a anabolic mu fibroblasts.
Izi zimawonjezera kupanga kwa collagen ya Type I ndi III, zomwe zimakulitsa dermis pomwe zimachepetsa mizere yabwino ndi makwinya okhudzana ndi ukalamba. 1
3.Imawonjezera Elastin Synthesis ndi Gulu
Myristoyl Pentapeptide-4 imawongolera elastin gene expression ndi kupanga mapuloteni panthawi ya fibroblast activation.
Imalimbikitsa mapuloteni omwe angopangidwa kumene kuti apangike kukhala maukonde opangidwa ndi fiber fiber, zomwe zimalimbitsa chitetezo cha khungu.
Izi kumawonjezera elasticity wa khungu, kusalaza msanga makwinya chifukwa cha kutayika kwa chithandizo chamkati, komanso kulimbana ndi kugwa.
Khungu limakhala losalala nthawi yomweyo, kukonza khungu lonse.
COA
Mtengo wa HPLC
MS
