Oligopeptide-2 is a bioactive peptide with high interest for the cosmetics sector, primarily used in anti-wrinkle and anti-aging products.
It is based on a fragment from the C-terminal region of the collagen α1 chain, involved in collagen–laminin–integrin crosslinking.
The endogenous peptide fragment, wat'i, is quickly broken down by proteases on the skin surface, hindering its effective penetration through the stratum corneum.
This has spawned a number of derivatives, the most successful of which is Oligopeptide-2.
A palmitoyl moiety is added to increase the lipophilicity of the peptide, facilitating its penetration through epidermal lipid bilayers and thus increasing overall stability for inclusion in cosmetic formulations.
consiguiente, Oligopeptide-2 has become a vital component in top quality cosmetics.
Secuencia
H-Lys-Thr-Thr-Lys-Ser-OH
'bede ya CAS
149128-48-3
Fórmula molecular
C23H45N7O9
Be̲xu molecular
563.65
Oligopéptido — 2 relacionados ár nthoni
1.nt'ot'e mbo ya nt'ot'e ne njapu'befi
Oligopéptido — 2 induce fibroblasto maduración, activa ya vías señalización intracelulares aguas abajo, aumenta notablemente ar ar síntesis ar novo ar colágenos ar klase I ne III, estimula eficientemente fibronectina ne glicosaminoglicano producción ne exhibe nt'ot'e quimiotáctica, 'ñäni ar migración ar fibroblastos ne ar agregación ja ya sitios objetivo, acelerando nja'bu̲ ar recuperación ar piel.
ko njapu'befi continuo, Oligopéptido — 2 reduce ar profundidad ne ar densidad arrugas faciales , mejora ar textura ar piel ne fortalece función barrera ar piel.
2.promueve síntesis colágeno
Oligopéptido — 2 bí une ma receptores específicos dige ya membranas fibroblastos, activando vía señalización TGF — β.
'me̲hna conduce jar activación ar síntesis colágeno asociada mRNA, da promueve ar producción intracelular altamente xi hño ne ngut'a ar precursor molecules for type I and III collagen.
These are further processed into complete and stable networks of collagen fibers.
This increases collagen fiber density and quality, resulting in improved skin elasticity and firmness and reduced wrinkles.
3.Stimulates Production of Fibronectin and Glycosaminoglycans, Enhancing Skin Hydration
In addition to collagen synthesis, Oligopeptide-2 stimulates the production and activation of fibronectin and glycosaminoglycans.
It enhances fibronectin synthesis and hyaluronic acid synthase activity, resulting in a gel matrix that improves the skin’s moisture retention capacity.
As a result the skin appears plumper, fuller and more hydrated.
4.Chemotactic Effect
Oligopeptide-2 has strong chemotactic properties, Fibroblastos guía ne yá células precursoras migrar direccionalmente nu'bu ya áreas ar piel dañadas.
'me̲hna optimiza significativamente ne acelera ar reparación ar piel, asegurando ar restauración mextha hño tejido dañado.
COA
HPLC
MS
