Biotinoyl Tripeptide-1 (isi igoa: GHK fa'aletino / Biotin-GHK / Biotinyl-Gly-His-Lys / Biotinyl-GHK) o se peptide olaola e fausia e ala i le so'otaga fa'atasi o le biotin (vaitamini H) ia GHK – le glycine-L-histidine-L-lysine tripeptide. O lenei fa'atasiga e fa'asaoina le fa'asologa autu o le GHK; fa'ata'ita'i fa'ataga e fa'atumauina a itiiti mai o nisi ituaiga o ana galuega fa'ale-natura, a'o fa'ailoa atu le malosi fa'apitoa fa'amau e mafai e le biotin.
Fa'asologa
Biotin-Gly-His-Lys-OH
Numera CAS
299157-54-3
Fuafua mole
C24H38N8O6S
Molecular Weight
566.7 g/mol
Suesuega ole Biotinoyl Tripeptide-1
O le fausaga autu o Biotinoyl Tripeptide-1 lava ia o le tripeptide GHK lenei. E tele su'esu'ega na faia i galuega fa'aolaola eseese a le GHK – toe faaleleia aano, e lua fa'ata'ita'iga sili o le anti-inflammation, faatasi ai ma le anti-matua o le vaega sili ona suʻesuʻeina talu ai nei.
O le biotin e avea o se coenzyme autu e faafaigofieina ai le tuufaatasia o le keratin (o le polotini muamua e maua i le lauulu); o le tausia o le soifua maloloina o lauulu o se tasi lea o ana matafaioi faifai pea. O le fa'afeso'ota'i i le peptide e maua ai se fesoasoani fa'aopoopo mea'ai, ae o le mea e sili ona taua o le biotin's latalata atoatoa le vavalalata mo sela follicle lauulu; fa'aleleia atili le lelei o le fusifusia i nei nofoaga fa'atatau, bioavailability ma i se tulaga aoga [1].
O su'esu'ega ua fa'ailoa mai ai le fa'atumauina manuia ole GHK's copper-binding, eseese antioxidant ma anti-glycation gaoioiga; fa'atatau ile tu'uina atu o le fa'aleleia muamua ole suiga ole biotin e mafai. Taofiga taua o acrolein (ACR)-fa'aosoina Aβ carbonylation (se fa'ailoga fa'aleagaina fa'ama'i) ma fa'aitiitia le fa'atupuina o mea fa'aopoopo ua matauina.
Ascorbic acid fa'ama'i fa'asalaina e le Cu(II)-Aβ faʻalavelave ua faʻalavelave foi, faaitiitia uma mulimuli ane ituaiga okesene fa'afoliga (ROS) tupulaga (toe, vaega aoga fa'atusatusa i le GHK mama ua va'aia, le nofoia C-terminal o se mea e ono tupu).
Su'esu'ega Spectrophotometric (2-(4′-Hydroxyazobenzene) Benzoic Acid/HABA fa'aliliuga) faʻamaonia maualuga streptavidin fusifusia e Biotinoyl Tripeptide-1 – o lo'o fa'atumauina le fa'atatauina o le maualuga ole paiotini mama.
O le Biotinoyl Tripeptide-1 o lo'o tumau pea ose peptide biotinylated tulaga ese, fa'atasi ma le leai o ni fa'aoga teuteu, i fa'amoemoega uma ma fa'amoemoega o se mole mole o lo'o fiafia tele i le fa'asaienisi ma le tagata fa'aaoga mulimuli.
O le Biotinoyl Tripeptide-1 e masani ona tu'ufa'atasia ma isi mea e fa'ato'a gau ai lauulu; minoxidil, finasteride, ituaiga eseese o la'au (vaai palmetto o se faataitaiga sili, salvia miltiorrhiza ma ginkgo biloba o loʻo suʻesuʻeina lelei foi), vitamini (biotin pe a ou manatua sa'o o le mea sili ona taatele, o vitamini B lautele), ma elemene e pei o le zinc ma le seleni.
O le tu'ufa'atasiga e mulimulita'i i le tele-target therapeutic approach – tautalagia mea ou te talitonu e tele, faiga pathophysiological tutusa o lauulu gau.
Biotinoyl Tripeptide-1 lava ia o se peptide multifunctional, o le taunuuga o nisi ituaiga o inisinia mole. GHK fa'afouga fa'afouga, antioxidant ma i se tulaga neuroprotective meatotino o loʻo tuʻufaʻatasia ma le poto ma le biotin's sili atu le mafai ona tuʻuina atu..
Fa'apisinisi i le fanua cosmetics ua fa'avaeina o ia e lua o se anti-matua ma (lata mai nei) mea e fa'aolaina ai le tuputupu a'e o lauulu. O le taʻua muamua faʻasaina o le amyloid aggregation o loʻo tuleia suʻesuʻega i luma; fa'ama'i neurodegenerative, Alzheimer fa'apitoa, o lo'o fa'amoemoeina talosaga i le lumana'i.
O suʻesuʻega loloto ma sili atu ona faʻamalamalamaina o le a naʻo le faʻamalamalamaina atili o le Biotinoyl Tripeptide-1 i tulaga uma o le soifua maloloina o le tagata ma faʻamaʻi..
COA
HPLC
MS
