Oxytocin o se neuropeptide e aofia ai le iva amino acids. Fa'atasi i totonu o le nucleus paraventricular (PVN) ma supraoptic nucleus o le hypothalamus, e teuina i le pitoitary pito i tua gutu. Na maua muamua ma fa'apipi'i fa'atusa i 1906, o lona aloaia masani o se hormone autu o le physiological e faʻataʻamilo i le amataina ma le lagolagoina o le galue; rhythmic uterine musele lamolemole malepelepe o le faiga autu o le gaioiga.
Pe'a failele le susu sela myoepithelial fa'aitiitiga (fa'afaigofieina uma le gaosiga ma le fa'aosoina mulimuli ane o le susu) o se isi matafaioi taua ua fa'amaumauina lelei. Fa'asao le gaioi o le popole alofa, fa'aitiitia le toto ma cortisol fa'atonuga, fa'amalolo manu'a ma tali uma e fa'atatau i le fa'ama'i o ni sao fa'aopoopo fa'aletino e faia e le oxytocin.
I le amataga o le seneturi na tuleia ai e le neuroscience le faʻamatalaga o le oxytocin atili; o se neuropeptide faʻaagafesootai na faʻaalia o le faʻamatalaga sili atu ona saʻo. O faʻataʻitaʻiga manu ua tuʻuina atu faʻamaoniga tele e faapea oxytocin receptor fa'aaliga o kenera e a'afia sa'o ai amioga fa'aagafesootai. O tulaga faʻale-agafesootai ma neuroregulatory o gaioiga ua vaʻaia nei o se vaega o mea o le oxytocin 'faia'.
Faʻaleleia le malamalama lautele, felagolagomai, ituaiga eseese o lagona alofa ma sootaga vavalalata ua faalauiloaina uma e ia. Fa'atonuga fa'aletonu ma lagona fa'apitoa, e ala i le taofiofia o le hypothalamic-pituitary-adrenal (HPA) axis, va'ai le oxytocin e fai ma fa'atonu autu.
Ole oxytocin ile falema'i e auai ile faiga fa'aletino – G porotini fa'apipi'i fa'afeso'ota'i e fa'asalalau lautele, ma aafiaga uma na ta'ua muamua (cardiovascular, mafaufau, po o se isi mea) e mafai ma o lo'o fuaina o ni taunuuga lelei o ana gaioiga. Fa'alavelave fa'ale-mafaufau mo fa'aletonu o alaleo autism, popolega lautele, Ma'i fa'ama'i fa'ama'i (PTSD) ma isi, o lo'o fa'atusa uma e ma i se tulaga fa'amatalaina e le oxytocin.
Fa'asologa
Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (Alalaupapa Disulfide:Cys1-Cys6)
Numera CAS
50-56-6
Fuafua mole
C43H66N12O12S2
Molecular Weight
1007.19
Su'esu'ega Fa'atatau ole Oxytocin
1.Fa'aosofia Fa'a'oto'oto
Talu mai lona mauaina, oxytocin ua faʻaaoga muamua mo lenei faʻamoemoega faʻapitoa – fa'aoso fa'ama'i fa'ama'i, fa'atupuina tulaga lelei mo le fa'atama. E fusifusia i oxytocin receptors (se ituaiga o G faʻapipiʻi faʻapipiʻi porotini) o lo'o i luga o sela maso lamolemole uterine. Fa'agaoioia o fa'apitoa ala o le calcium totonu le membrane sela e taʻitaʻia ai se faʻaopoopoga tele i calcium intracellular fa'atonuga.
Myosin kinase filifili mama ona fa'agaoioia lea, e i'u ai i le fa'ato'a ta'ua i luga ole fati ole maso lamolemole endometrial. O nei 'ulu i lalo’ fa'ato'ato'a e pei o le tuleia ma le lima o le tama i fafo.
O fa'ata'ita'iga fa'afoma'i ua fa'aalia ai le fa'aogaina o le toto e fa'aitiitia ai le va o le va'a 2-3 minute; o le fa'aumiumi o le umi ose fa'amaumauga lelei fo'i, o lo'o fa'atupuina fa'aitiitiga lelei o tagata faigaluega. O isi suʻesuʻega o loʻo faʻaalia ai o le oxytocin-induced contractions e le naʻo se meafaigaluega faʻafaigofie i le tuʻuina atu., tapuni vave vascular i le nofoaga tuueseeseina (puipuia o le toto o se tasi lea o taunuuga sili ona taua) o lo'o fa'atinoina se vaega taua.
2.Fa'alauiloaina o le Su'e Su'e
E fa'alagolago le tulia o le susu i le neuroendocrine reflex system, le let-down reflex. O le susuina e le pepe o le susu o le tina e maua ai le uluai faaosofia, fa'ai'uga neura e tu'uina atu fa'ailoga i le hypothalamus. Oxytocin e fa'apipi'iina ma fa'asa'oloto ai, fealua'i i totonu o le toto e galue i sela o le myoepithelial (si'osi'omaga mammary alveoli ma ala laiti), o lo latou fa'aitiitiga o le fa'ai'uga lea o le fa'ate'aina o le susu.
O se tasi su'esu'ega na maua ai amioga a tina i isumu fafine na taofia ina ua uma 3 itula o le anapogi, o le fa'agaioia o le suasusu o se tasi lea o amioga fa'aletonu. Oxytocin fa'atele na toe fa'afo'i atoa ai lenei amio – fa'amaoniga sa'o o lona aoga i le fa'aolaina o le susu.
3.Fa'alauiloaina o Amio Fa'aletagata
O fegalegaleaiga faʻaagafesootai e i ai se tikeri faʻamalosi i totonu o le faiʻai o le tagata. E fa'aaoga muamua e tagata manatu faapito o le orbitofrontal cortex (OFC) ia fa'agasolo ituaiga uma o 'taua fa'aagafesootai', prosocial tagata sili atu faapea le amygdala. Fa'asoa tutusa ose fa'alavelave fa'ale-aganu'u.
O le pulega o le Oxytocin ua faʻaalia e tuleia ai tagata manatu faapito agai i amioga sili atu ona faʻavaeina.
4.Fa'atonuga o le fatu ma le fa'aleleia o Tissue
Fa'ama'i fatu fatu o le mafuaaga autu lea o le oti i le lalolagi atoa. Myocardial infarction i'uga i le tele oti cardiomyocyte; o le leai o se malosi e toe fa'aleleia ai le tagata lava ia i totonu o cardiomyocytes matutua e fai ma fa'alavelave muamua i so'o se ituaiga o le toe fa'aleleia o le fatu..
Mulimuli i manu'a cryogenic i fatu zebrafish, na matauina e le au suʻesuʻe le faʻateleina o le oxytocin mRNA faʻamatalaga i le faiʻai, ose taunuuga tumau maualuga o le oxytocin faapitoa i totonu o le fatu lava ia. O le fa'asaina o vaila'au o lenei fa'amatalaga oxytocin na matua taofia ai fa'agasologa uma o le fa'aleleia o fatu – fa'agaoioia o sela epicardial fou o se tasi lea o fa'ata'ita'iga iloga.
O lenei suʻesuʻega o le muamua lea na faʻamalamalamaina manino le taua o le oxytocin, sao fa'alauiloa i nisi vaega o le lipeaina o sela fatu.
5.Anti-inflammatory
I ituaiga eseese o ma'i cardiovascular, O le mumū maualalo faifaipea ma le faʻamaʻi faʻamaʻi faʻamaʻi o se isi pa puipui lautele i le toe faʻaleleia lelei o sela. Oxytocin e matua taofiofia le tuʻuina atu ma le faʻaalia mulimuli ane o le tele o mea faʻapitoa, fa'aitiitia le fa'atupuina o sela inflammatory moni, ma e ala i le faaleleia (fa'atosina) antioxidants pei glutathione peroxidase, fa'aitiitia vaega uma o lena fa'aleagaina fa'ama'i.
6.Fa'atonutonuina le Mana'o ma le Metabolism
Oxytocin e faia se sao taua i le manaʻo ma le tele o metabolism lautele. Fa'apipi'iina i neu o le hypothalamic e fa'ata'ita'i atu i vaega uma o fai'ai, e fa'ateleina fa'ailoga maoona (fa'avae fai'ai) – o se ‘ato‘atoa malosi lata mai’ being the end result of feeding.
Direct central nervous system action on dopamine seeking pathways reduces the motivation to seek out high reward foods (fat/sugar being prime examples). Studies have also shown oxytocin to increase insulin from pancreatic β-cells, and enhance glucose homeostasis.
COA
HPLC
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