Acetyl Tetrapeptide-22 (zita rechiratidzo Thermostressine®) is a synthetic bioactive peptide inoumbwa neina amino acid zvisaririra, ine acetylated N-terminal shanduko. Iyi chaiyo shanduko inowanzo gadzirirwa kuvandudza kugadzikana kwepeptide uye kunotevera kupenya kweganda. Kuita sechiratidzo chepeptide, inogadzirwa kuti itevedzere mamwe masaini echisikigo mamorekuru ayo muviri wemunhu unoshandisa; kudzora mamwe maseru eganda mashandiro ari iwo chinangwa chekutanga. Yakaiswa zvakanyanya semudziviriri weganda uye mune dzimwe nguva mugadziri wekugadzirisa, kusanganisirwa kwakapararira mune akasiyana cosmetic uye ega ega zvigadzirwa mhedzisiro yekushanda uku.
Kutevedzana
Ac-His-Leo-Leo-Arg
Nhamba yeCAS
1295648-76-8
Molecular Formula
C26H45N9O6
Molecular Weight
579.69 g/mol
Tsvagiridzo yeAcetyl Tetrapeptide-22
Acetyl Tetrapeptide-22 inowira pasi peiyo biomimetic peptide mhuri – iyo acetylated fomu iri iyo inotarisisa yezvakawanda zvekutsvagisa kwazvino. Kuvandudza ganda rekuvhara basa uye ese ane hukama mafomu ekusimba kwezvakatipoteredza zvikonzero zvakakosha zvekuiswa kwayo sechinhu chinoshanda., ‘kugadzirisa ganda’ kuva imwe yezvinonyanya kukumbirwa kupedzisa kushandiswa. Zvakafanana acetylated peptides (Acetyl Tetrapeptide-2, Acetyl Tetrapeptide-3 kana ndangariro dzichindishandira nemazvo) govera chinangwa chimwe chete ichi; kugadzikana uye permeability kuva magumo ekupedzisira anowanikwa kuburikidza neacetylation process.
Iyo yekutanga biological basa reAcetyl Tetrapeptide-22 iri kusimbisa iyo yemukati yekudzivirira sisitimu yemasero eganda.. Regulating Heat Shock Mapuroteni (HSPs) ndiko kutarisisa kwepedyo kwemaitiro ayo.
Tsvagiridzo mune chaiyo meshini yakatungamira mukunzwisisa kwazvino kuti Acetyl Tetrapeptide-22 inoshanda senge molecule inosaina.. Keratinocytes (uye kusvika kune imwe nzvimbo masero ose eganda) gadzirisa synthesis ye HSP70 mukupindura peptide. HSP70 pachayo inochengetedza mapuroteni homeostasis; kuziva mapuroteni akakuvadzwa, kushandisa simba rawo ATPase kutenderera kuapeta zvakare kana kutumira kuti adzikisirwe. Kudzivirirwa kwekuunganidza uye kufa kwesero rakazara kubva mukushushikana kwakanyanya ndiwo mugumisiro wezvose izvi.
Masero eganda (uye masero ose kusvika pamwero wakati) nguva dzose inogara yakagadzikana, low-level 'defense’ state. Acetyl Tetrapeptide-22, uye ese akafanana peptides, zviripo uye zvichagara zviripo, kudzivirira kune imwe nhanho yekushushikana.
Kushandisa mabasa ayo akasiyana ebhayoloji, acetyl tetrapeptide-22 inoshanda seyepamusoro-tekinoroji inoshanda mukati mezvizorwa magadzirirwo.. Yakabatanidzwa zvakanyanya mu-anti-stress uye inonyaradza kugadzirisa zvigadzirwa, inodzivirira ganda kubva kune vakasiyana-siyana zuva nezuva vanoshungurudza zvakatipoteredza – kubuda kwezuva, kusvibiswa, Mamiriro ekunze akashata ari mienzaniso mikuru.
Sensitive ganda kugadzirisa, post-sound iyo, uye routine kugadzikana kuchengetedza zvese zvakanyatsokodzera kushandiswa kwayo. Panguva imwe chete imwe yemhando yekudzivirira yeanti-kuchembera chigadzirwa ichasanganisira iyi ingredient. Kudzivirira maseru kubva kumberi apoptosis uye kunotevera kushanda kuderera, kuchengetedzwa kwemuviri uye pedyo-yakanaka huduku hweganda ndicho chinangwa chekupedzisira; zvakatipoteredza uye kune imwe nhanho zvinonetsa zvemuviri ndizvo zvinomiririra kuchembera.
Specialized care nzvimbo (‘kununura’ zvigadzirwa kana uchida, vafambi nguva zhinji, mazizi, zvirongwa zvisina kurongeka zvese zvinokwana pano) ona kukurumidza kupora kwechinguva chidiki chakaderera mamiriro eganda semhedzisiro yakanaka.
Acetyl Tetrapeptide-22 inovimbisa cosmetic peptide; kugadzirisa kweganda uye zvese zvine chekuita nekudzivirira kushushikana kuve kukosha kwayo kwepakati. Mabhuku azvino akadhindwa anopa kuburitswa kushoma kwechero nzira kana data rekiriniki kutsigira izvi zvirevo. Rondedzero yechigadzirwa chemhando inosundira miganhu yezvatinoziva, uye akafanana peptides ave (uye ramba uripo) akadzidza.
Kusimbisa huwandu hwakazara hwebiological uye kiriniki efficacy yeiyi kana chero peptide, ndiro remangwana chairo recosmetic science.
COA
HPLC
MS
