Hexapeptide-9 (Hexapeptide-9, zita rekutengesa Collaxyl™) is a synthetic bioactive peptide inoumbwa nematanhatu chaiwo amino acids. Iyo chaiyo chimiro chepeptide iyi inowanikwa mukati memunhu collagen IV uye XVII; izvi zvichinyatsobatanidzwa nezvikamu zvakakosha zveganda repasi membrane. Biotechnologically synthesized kutevedzera vamwe, kana zvisiri zvose, mabasa echisikigo collagen, kuchena uye kugadzikana nyaya dziripo mune mamwe 'chinyakare’ zvinyorwa zvechisikigo zvinobviswa. Kugadzikana kwepamusoro uye kugadzirwa kuri nyore kwaita kuti pave pedyo nekutorwa kwepasi rose mune dzakasiyana siyana anti-kuchembera skincare zvigadzirwa..
Kutevedzana
Gly-Pro-Gln-Gly-Pro-Gln
Nhamba yeCAS
1228371-11-6
Molecular Formula
C₂₄H₃₈N₈O₉
Molecular Weight
582.28 g/mol
Tsvagiridzo yeHexapeptide-9
Multiple multifaceted maitiro ekuita akanyorwa eHexapeptide-9. Nzira yekutanga yebiological messaging inoshandiswa – activate uye wozodzora ganda remukati synthesis uye kugadzirisa nzira.
Kukurudzira Collagen Synthesis: Kukurudzira kwakananga kwedermal fibroblasts ndeimwe nzira yakadaro; yakawedzera kugadzirwa kweese Type I uye Type IV collagen kuve mhedzisiro. Type I inoshanda seyapedyo yerutsigiro yemaitiro inowanikwa mudermis, resilience kuve yakananga byproduct. Type IV (iyo 'mwana collagen’ kana muchida) inobatanidza elasticity uye kuwedzera kutsvedzerera kweganda.
Kukwidziridzwa kweaya ese ari maviri macollagens kunotungamira kugadziriso inobudirira kweiyo inodzika dermal architecture., kuderedza kudzika kwekukwinya uye kuvandudzwa kwese kwakatenderedza mukusimba.
Kusimbisa iyo Dermal-Epidermal Junction(MVURA): Apa ndipo panozvimisa chaizvo Hexapeptide-9. Iye DEJ (zvakare, zambuko chairo) inodzoreredzwa zvishoma nayo. Laminin-5 uye Type IV collagen synthesis mukati meiyi nharaunda ndiyo inoita kuti Hexapeptide-9 ive yakakosha kumushandisi wekupedzisira..
Kuendeswa kwekudya kunovaka muviri, kuvimbika kwechimiro uye zvese zvinotevera, ihondo inogara ichirwisana nenguva uye kuderera.
Kuvandudza Skin Barrier uye Hydration: Kupfuura dermal zviito zvayo, Hexapeptide-9 inomhanyisa epidermal kugadzirisa maitiro. Kudzorera ganda rakakuvadzwa (post-acne marks, marudzi akasiyana-siyana ekukwenya, kana kunyange mamwe post-aesthetic maitiro maitiro) ndeimwe yemashandisirwo ayo akakosha.
An in vitro efficacy kudzidza yakanyatso ratidza kukwidziridzwa kwe iyo filaggrin (FLG) gene; kusiyanisa epidermal uye kuzoita barriers basa kunoenderana zvakanyanya neprotein iyi. Filaggrin pachayo inotangira kune izvo zvinozivikanwa se Natural Moisturizing Factors – kuwedzera kuvapo kuve chiratidzo chakananga chenguva pfupi uye kwenguva refu yeganda hydration, nzvimbo yepedyo yekupedzisira yekudzivirira kwekudzivirira.
Zvidzidzo zvekiriniki zvakaratidza kuwedzera mune yakazara collagen kugadzirwa (kusvika pa 117% kana ndikarangarira zvakanaka) uye kuwedzera kusinganzwisisike asi kunoyerwa kuvandudzwa mu elasticity.
Uyezve, tsvagiridzo yave kunanga kune cyclic hexapeptide-9 (CHP-9) sechinogoneka chepamusoro chekudzivirira kuchembera. Traditional linear peptides vane nzvimbo yavo, asi chimiro che cyclic chinopa kugadzikana kukuru, yakawedzera bioavailability uye zvese zvakatenderedza physiological chiitiko.
Kushandiswa kwepamusoro kweimwe fomu yeiyi cyclic peptide mutsara unovimbisa wepfungwa kudzivirira kana kunonoka kuchembera kweganda.. Kusimbisa zvese zvataurwa pamusoro apa mabhenefiti kuburikidza nezvidzidzo zvakadzorwa zvakanaka ndiyo nhanho inotevera ine musoro.
COA
HPLC
MS
