Oligopeptide-41 inonyanya kushanda peptide inoshandiswa mukati mezvizoro uye zvakasiyana-siyana zvekuchengeta bvudzi zvigadzirwa..
Yakatorwa kubva mukuenzanisa uye optimization ye β-hairpin chimiro chakanangana ne keratinocyte kukura chinhu(KGF), inonanga bvudzi follicle stem masero.
High affinity kuchengetedza kune iyo FGFR2-IIIb subunit inochengetwa, nekudzikisira kwakakosha mukuchinjika-kusunga kune FGFR1; kuderedza mitotic yambotaurwa “isiri-bvudzi follicle” side effects uye kuwedzera hafu yeupenyu.
Maside effects (itching, pigmentation yeziso kuva mienzaniso mikuru) zvinonyanya kudziviswa.
Kutevedzana
Ala-Ser-Ala-Lys-Trp-Thr-His-Asn-Gly-Gly-Glu-Met-Phe
Nhamba yeCAS
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Molecular Formula
C63H90N18O19S
Molecular Weight
1435.58
Oligopeptide-41 Inoenderana Tsvagiridzo
1.Maitiro Ekuita uye Kubudirira
Miedzo yakaratidza iyi peptide inomisa nzira mbiri – β-catenin/Wnt uye SEI-STAT5 – muORSc stem masero; kukwidziridzwa kweinoenderana protein kutaura uye anti-apoptotic zvinhu zvinotevera.
Kuwedzera chikamu chekukura kwebvudzi rebvudzi ndiyo mhedzisiro yakananga, melanocyte stem cell kusiyanisa kuri kukurudzirwa, grey kupararira kwebvudzi kwakaderedzwa zvakanyanya.
Local microcirculation inowedzerwa, antioxidant kugona kwe melanocytes kuwedzera uye hydrogen peroxide mazinga akaderedzwa.
2.Kushanda katatu kunowanikwa
kudzivirira kurasikirwa kwebvudzi, kukurudzirwa kwekukura kwebvudzi rinoshanda, kunonoka kana kumira kuchena zvachose.
3.Kuwedzera Anagen Phase
Kusunga kuFGFR2-IIIb receptors pane follicular cell surface induces receptor dimerization uye inotevera phosphorylation.
Iyo Wnt/β-catenin nzira inoshandiswa, keratinocyte precursors inoramba iri mu stem state, kuguma kusiyanisa kwakanonoka.
Ex vivo vhudzi revanhu follicle tsika mhando dzakaratidza kuwedzera kwakajeka uye kuyerwa mune zvese nguva uye density yeanagen phase..
4.Kuita melanocyte stem masero uye kuvharidzira grey bvudzi
Pax3 uye MITF-M gene expression inodzorwa.
Kusiyanisa mu melanocyte yakakura kunosimudzirwa.
Miedzo yemakiriniki inotsigira ese ambotaurwa mabhenefiti eOligopeptide-41.
Mamwe mabasa epeptide ari kudzidzwa, asi ese akabatanidzwa kune yakare yakatsanangurwa nzira.
Nyowani microcirculatory uye anti-kuzvimba mhedzisiro ndeyekunyanya kufarira kune ramangwana rebvudzi uye hutano hweganda.
COA
HPLC
MS
