Acetyl Tripeptide-1 is a synthetic repair signal peptide, synthesized via N-terminal acetylation (“capping” modification) of the naturally occurring tripeptide GHK found in plasma and has a chemical structure similar to Acetylated Polypeptide-1. This structural modification addresses the aforementioned inherent challenges of the original GHK, including instability due to aminoxidases, inactivation in cosmetic formulations, and a short half-life.
خلاصہ میں, Acetyl Tripeptide-1 effectively reduces fine lines and wrinkles, tightens the skin, and refines skin complexion. It is an anti-aging ingredient with a clear mechanism of action, high specificity, and demonstrated efficacy.
ترتیب
Ac-Gly-His-Lys-OH
CAS نمبر
350595-76-5
مالیکیولر فارمولا
C16H26N6O5
سالماتی وزن
382.42
Acetyl Tripeptide-1 Related Research
1.Core Mechanisms and Multi-faceted Effects
The acetylated GHK exhibits increased hydrophobicity and a prolonged half-life while preserving its reversible Cu²⁺-chelation properties. These properties facilitate the formation of copper-peptide complexes within the dermal layer, enhancing efficacy without increasing cytotoxicity.
It acts on dermal fibroblast cells to counteract aging induced by chronological or environmental factors. Through binding to specific cell surface receptors, it activates major intracellular signaling cascades to modulate cellular function at the genetic level.
It strongly stimulates the synthesis and secretion of Type I & III collagen and elastin, resulting in denser, thicker skin. This, in turn, reduces wrinkles, sagging, and hollowing caused by collagen loss.
It also suppresses excess matrix metalloproteinase activity, establishing a protective skin microenvironment that reduces degradation of the native extracellular matrix.
2.Promotes Collagen and Elastin Synthesis
Acetyl Tripeptide-1 reaches the dermal layer of the skin, where it acts as a ligand for specific receptors on the fibroblast cell membrane. This binding activates the mitogen-activated protein kinase (MAPK) اور phosphoinositide 3-kinase (PI3K) signaling pathways, promoting fibroblast proliferation and upregulating انابولک میٹابولزم.
At the transcriptional level, it enhances the expression and synthesis of Type I collagen, Type III collagen, اور ایلسٹن, thereby increasing their concentration and density in the dermis. This leads to plumper, more voluminized skin. ¹
3.Inhibits Excessive Matrix Metalloproteinase Expression
Acetyl Tripeptide-1 modulates cellular signaling to limit the overproduction of matrix metalloproteinases (ایم ایم پیز), while also mitigating ongoing ایکسٹرا سیلولر میٹرکس degradation by suppressing their synthesis at the transcriptional level.
Preserving existing collagen through this mechanism helps maintain dermal thickness and integrity, extends collagen turnover time, and thus contributes to delaying the aging process. ²,³
4.Enhances Cellular Skin Repair Function
Acetyl Tripeptide-1 activates the PI3K/Akt pathway, a key regulator of cellular survival, ترقی, and metabolism. This stimulation boosts fibroblast activity and enhances the repair of daily microtrauma.
It also scavenges free radicals generated via metal-ion catalysis, thereby indirectly preventing آکسیڈیٹیو تناؤ-induced cellular damage and promoting healthier skin. ⁴
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