I-Acetyl Hexapeptide-38 (Igama lorhwebo Adifyline®) yipeptide yokwenziwa esetyenziswa kakhulu ngaphakathi kweyeza lobuhle kunye nokulungiswa kolusu. Ukujolisa iifibroblasts zesikhumba, ikhuthaza ukuhlanganiswa kwe-collagen kunye nokuqina kwamafutha angaphantsi; ukuphuculwa kwesakhiwo solusu kunye neendlela ezahlukeneyo zokulungiswa kwezicubu ziziphumo ezithe ngqo zalo msebenzi.
Ulandelelwano
Ac-Ser-Val-Val-Val-Arg-Thr-NH₂
Inombolo yeCAS
1400634-44-7
Ifomula yeemolekyuli
I-C30H56N10O9
Ubunzima beMolekyuli
700.83 g/mol
Yintoni iAcetyl Hexapeptide-38
I-Acetyl Hexapeptide-38 ngokwayo i-acetylated modified peptide – ii-amino acid ezintandathu ubude. Uyilo lwemolekyuli yepeptide lulinganisa iipeptide zendalo zebhayoloji, kunye neenzuzo ezongezelelweyo zokunyuka kozinzo kunye nokuphucula ukugqithiswa kwesikhumba.
Iqale yaphuhliswa ziinkampani zokuthambisa kunye ne biomaterial, ukuguga kwesikhumba (imibimbi, ukuyekelela, iziphene kwizicubu ezithambileyo zibe yimizekelo ephambili) zizinto le peptide yayidalelwe ukujongana nayo. Uphando lubonise ukungena okusebenzayo kudlulileyo umqobo wokuqala wesikhumba; ukusebenza ngaphakathi kwidermis, Ukulawulwa kwe-extracellular matrix metabolism yinkqubo ephambili ekhokelela kuzo zonke iindlela zokulungiswa kwesakhiwo kunye nokulungiswa okulandelayo..
Umsebenzi ongundoqo we-Acetyl Hexapeptide-38 ngoko ke njengomgqugquzeli wokulungisa izicubu ezibanzi. Iifibroblasts zesikhumba kunye adipocytes zizinto ekujoliswe kuzo eziphambili, ngeenkqubo ezithile zebhayoloji zilawulwa kuyo yonke indawo.
Okwangoku eyona ndlela kuxoxwa ngayo ngokubanzi ibandakanya ukuvuselela intetho ye I-Peroxisome Proliferator Esebenzayo I-Receptor ye-Gamma Coactivator 1-alpha (PGC-1α). I-PGC-1α ngumlawuli ophambili we i-biogenesis ye-mitochondrial kunye nayo yonke i-metabolism yamandla enxulumene. Ukulawulwa okuphezulu kwale proteni kukhokelela ekubeni (ubuncinane ngokuyinxenye) ukwanda kwe-lipid synthesis kunye nokuqokelela kwi-adipocytes – ukwanda komthamo wezicubu ze-adipose sisiphumo sokugqibela. Ubuninzi besikhumba kunye nokunciphisa imibimbi ye-atrophic zombini zizibonakaliso zeklinikhi ezintle zesi siphumo.
Le propati yenza uhlobo lwendalo olungakumbi lokunyusa umthamo wamafutha (izidlele zobuso, amabele njl.) ukuba kuphunyezwe; ‘ipeptide yokuphucula ibele’ yinkcazo eqhelekileyo yolunye usetyenziso lwayo.
I-Acetyl Hexapeptide-38 yongeza ukuxinana kunye nokuzinza kwe i-collagen fibers kwidermis, njengoko bekutshiwo ngaphambili, kuzo zonke ezi ziphumo zidibene zingentla.
Ngokusekelwe kuzo zonke iindlela ezichazwe, I-Acetyl Hexapeptide-38 inekamva lokwenyani kwaye lithembisayo kunyango lobuhle. Ukulungiswa kweendlela ezimbini kunye nokujiya kwezicubu ezithambileyo yindawo enqwenelekayo yokuphela.
I-Acetyl Hexapeptide-38 ngumgqugquzeli othembisayo wokulungisa ulusu.
I-COA
HPLC
NKSK
(2) DELGADO GONZÁLEZ, R.; I-SOLEY ASTALS, A.; INKUNDLA, A.; UTHOLAS, B. I-EXOPOLYSACCHARIDE YONYANGO KUNYE/OKANYE UKUKHATHALELA ULUSU, AMANQAKU OMBUDU KUNYE/OKANYE NEZINzipho. EP2827837B8.
(3) Wu, Y.; Ewe, H.; ULyu, Y. Inkqubela phambili yophando lwe-collagen peptides yendalo kunye nokusebenza kwayo kwe-skincare. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2022, 39 (6), 1254-1262. DOI: 10.7507/1001-5515.202207009 Ukusuka kwi-NLM.
