I-Acetyl Tetrapeptide-11 (Igama lebrand Syniorage™) luphawu lwepeptide yokwenziwa. Uphando olubanzi ngaphakathi kwecandelo lezithambiso lujolise kubuchule balo bokuphucula izikhombisi ezahlukeneyo zomzimba zokuguga kwesikhumba.; ukuqina, ukuqina, kunye nohlobo lokukhazimla kuba yeminye yemizekelo ebhalwe kakuhle.
Ulandelelwano
Ac-Pro-Pro-Tyr-Leu
Inombolo yeCAS
928006-88-6
Ifomula yeemolekyuli
C27H38N4O7
Ubunzima beMolekyuli
530.6 g/mol
Uphando lweAcetyl Tetrapeptide-11
Umsebenzi ongundoqo webhayoloji we-Acetyl Tetrapeptide-11 amaziko malunga nokugcina kwaye kwezinye iimeko ukulungisa, ulwakhiwo kunye nokusebenza imfezeko Indawo yeDermal-Epidermal Junction (AMANZI). Iindlela ezimbini eziphambili zinoxanduva lwale ndlela yokusebenza:
Ukukhuthaza ukwanda kwe-keratinocyte: IiKeratinocyte zenza i-epidermis ngokwazo. Ukunyuka okuqhelekileyo kunye nokuhlukana okulandelayo kuzo zonke iinkalo zomqobo wesikhumba osebenza ngokufanelekileyo, uzinzo lwesakhiwo, kwaye kumlinganiselo omkhulu ukuzilungisa. Njengomqondiso we-peptide ikhuthaza ngokuthe ngqo ukukhula kwe-epidermal keratinocyte, ukwanda koxinzelelo lweeseli ibe sisiphumo esilinganisekayo, ukuvuselelwa okukhawulezileyo kube sisiphumo sale nkqubo.
Ukukhuthaza iGlycoprotein Synthesis – ngokukodwa syndecan-1 kwaye kwinqanaba uhlobo XVII collagen. Syndecan-1 (transmembrane heparan sulfate proteoglycan ukuba ndikhumbula kakuhle) ibopha iintambo (iimolekyuli zokunamathela kwiseli, izinto ezahlukeneyo zokukhula) ngamatyathanga ayo asecaleni; i-intercellular adhesion kunye nazo zonke i-microenvironmental interactions ezinxulumene nazo zilawulwa. Uhlobo lwe-XVII i-collagen yinxalenye ebalulekileyo ye-hemidesmosomes. Ukudibanisa okucuthiweyo nokuba kukuphi, ngokuguga, kukhokelela ekomeni, ukuyekelela okukhankanywe ngaphambili. Ukuphucula umqobo wokusebenza kunye nokuqaqamba zizo zombini iinzuzo zomyalelo wesibini we-Acetyl Tetrapeptide-11.
Iingxelo ezongezelelekileyo zezenzululwazi zibonise uthintelo olusondeleyo olupheleleyo lwemiqondiso yosasazo lwe-neuromuscular (ngokuthintela i-SNARE receptors), ukunciphisa ukukhululwa okugqithisileyo kwe-catecholamine kunye ne-acetylcholine. Imibimbi enamandla iyancitshiswa sesi senzo ngokunjalo.
Izifundo zeklinikhi ziqinisekisa ukuba iifomyula eziqukethe i-acetyl tetrapeptide-11 (umz., kwi a 3% ugxininiso) ukwandisa ngokuphawulekayo zombini ubukhulu bolusu kunye nokuqina. Olunye ulingo oluchanekileyo olubandakanyekayo 19 amavolontiya abhinqileyo; imveliso ekuthethwa ngayo yayikuphela kwento esebenzayo. Iziphumo zibonise ngokucacileyo, Umahluko onokumetwa kwiqela lolawulo lwe-placebo – abantu abasebenzisa i-acetyl tetrapeptide equlethe ukwakheka babe ngqindilili, ulusu oluqinileyo ngakumbi.
Olu phononongo luyixhasa ngamandla ‘inguqulelo’ ezahlukeneyo ze-in vitro ziqwalasele imisebenzi yebhayoloji ekuphuculeni ulusu olubambekayo. Ubungqina obusekwe kubungqina bokuchasa ukuguga yinto esi sithako sizenzele yona.
Ngenxa yale ndlela ikhethekileyo yokwenza, I-Acetyl Tetrapeptide-11 idityaniswe ikakhulu kwiindlela zokuthambisa ezichasene nokwaluphala.. Ukuqina kwesikhumba, ukuxinana (yeentlobo ngeentlobo), kunye necontour elula iyonke zonke ziphuculwe yiyo.
Umqondiso we-peptides usebenza njengeemolekyuli ezigqibeleleyo zezithunywa; Iimpendulo ezinamandla kodwa ezithe ngqo zeselfowuni ziyaqhutywa, ukugxila okuphantsi kube yiyo yonke into efunekayo. Amanqanaba aphezulu okanye akufutshane ahlala ehleli kwipeptide ngokwayo ayifuneki – iinxalenye zodidi lwesigidi esongezo ziqhelekileyo kwaye ziyasebenza.
I-COA
HPLC
NKSK
