I-Crystagen yipeptide ebalulekileyo ye-bio-regulatory eyenzelwe ukomeleza amandla okulawula amajoni omzimba.. Uphononongo olucwangcisiweyo lwe thymus umsebenzi kunye nezinto zayo ezifihlakeleyo zikhokelele ekudibaneni kwayo ngoyilo oluyilwe ngabom kakhulu.
Ukususela ekufumaneni, amanqanaba amaninzi, Izakhono ezininzi zokulawula ibhayoloji ekujoliswe kuzo ziye zaboniswa kwiCrystagen. Ukusebenza okuphambili kulele ekuphuculeni ngokubonakalayo nangokuchanekileyo imiba eyahlukeneyo yokusebenza kwamajoni omzimba.
Immunomodulatory amandla avela ngokukodwa kulawulo olulungileyo lwento ethile T lymphocyte iiseti ezincinci – umncedisi Th iiseli ukuba ngumzekelo obalaseleyo, ihamba ne iiseli T ze-cytotoxic; ukuvuselela kwabo ukwanda, ukusebenza, kunye nokukhuselwa okulandelayo kwe isiphumo iimolekyuli zingundoqo kule nkqubo.
B-iseli ukusebenza okunxulumeneyo kunye ukukhuseleka kwe-humoral nayo imodareyithiwe, synergistically ukugqiba impendulo yomzimba.
Ukulinganisa i-endo native immune signing molekyuli ngokwayo yenye yeendlela eziphambili zeCrystagen; ligand-Ukusebenzisana kohlobo lwe-receptor kumphezulu weeseli zokuzivikela ziqala iindlela ze-intracellular.
Ezinye izifundo zeklinikhi ziye zachaza umphumo ochasene nokuvuvukala, ukunciphisa iintlobo ezahlukeneyo zoxinzelelo lwe-immune umonakalo owenziwe ngumzimba.
Ukwenziwa kwesiqhelo kweemeko zendalo esingqongileyo sisiphelo esinqwenelekayo.
I-immunomodulation enamandla (yangoku kunye nekamva) yeyona nto iCrystagen ijolise ukuyifumana.
Ulandelelwano
Glu-Asp-Pro
Inombolo yeCAS
/
Ifomula yeemolekyuli
I-C14H21N3O8
Ubunzima beMolekyuli
359.335
Uphando lweCrystagen Peptide
1.Ukulawula iilymphocytes
Intshukumo ngqo amajoni omzimba iimpendulo yeyona nto iphambili ekugxilwe kuyo yiCrystagen.
Ngesantya, ukusebenza okusebenzayo ngakumbi kunye noluhlu olupheleleyo lolwahlulo olufanelekileyo kwiiseli ze-T ezisebenzayo i-antigen ukudibana zonke ziyinxalenye yale nkqubo.
2.Uhlengahlengiso lwe (iyacwangciseka) ukubonakaliswa komzimba
Njengoko kukhankanyiwe ngasentla, onke amanqaku angaphambili akhokelela ekusebenzeni okucwangcisiweyo kwe-immune system.
Iiseli ze-immune ziyakwazi kwaye ziya kutshintsha imeko yazo ekuphenduleni i-Crystagen.
3.uKhuseleko lweSeli kunye noLondolozo lwe-Homeostatic
ICrystalgen ithomalalisa ukonakaliswa koxinzelelo lweoxidative ngokukodwa kwiiseli zomzimba.
Ukulawulwa kweentlobo ezahlukeneyo ze-antioxidant ze-intracellular (iglutathione ukuba ngumzekelo obalaseleyo) yeyona ndlela iphambili yesenzo kule nkqubo.
Ngaxeshanye, uthintelo lwe imitochondrial apoptosis indlela – ngokusebenzisa inkcazo elawulwayo ye BCl-2 usapho iiprotheni – iyaqwalaselwa; ukunciphisa i-apoptosis yezi seli ngokuthe ngqo kukhokelela kumaxesha okuphila ixesha elide kunye nokunyamezela okusebenzayo okulandelayo.
Ukugcina i-microenvironment ezinzileyo ngaphakathi komzimba yenye ipropathi ephambili eboniswa yiCrystalgen.
Ukulawula (nokubuyisela) Umlinganiselo ofanelekileyo weeseti ezahlukeneyo zeeseli zokhuselo lomzimba yindlela le misebenzi yokhuselo lomzimba iphinda imiselwe kwakhona: ukubek' esweni, ukhuselo olusebenzayo, kunye nemisebenzi yokucoca.
Umhlaza unyango lwe-adjuvant sesinye sezicelo ezinqwenelekayo zokuphela kwalo mgca wokhuselo lomzimba.
I-COA
HPLC
NKSK
