IiOligopeptides 24 yi-synthetic bioactive peptide eyenziwe ngokuchanekileyo 13 iintsalela ze-amino acid.
Ithathwe kwiqhekeza le-enzymatic elicandekileyo elastin, inomsebenzi owodwa webhayoloji.
Ukuphuculwa okuqhubekayo, ukuhlolwa, kwaye ulungelelwaniso lolandelelwano lusetyenzisiwe ukuphucula transdermal amandla okufunxa.
Ukubandakanywa ngabom kwe i-disulfide iibhondi zisebenza ukuzinzisa isakhiwo sayo.
Olu hlengahlengiso aluwunciphisi umsebenzi wayo webhayoloji; inyaniso, imisebenzi yendalo yeprotheyini ye-bioactive igcinwa kakhulu.
Ulandelelwano
Cys-Met-Tyr-Ile-Glu-Gly-Gly-Gly-Gly-Arg-Gly-Asp-Gly
Inombolo yeCAS
1018685-16-9
Ifomula yeemolekyuli
I-C50H78N16O19S2
Ubunzima beMolekyuli
1271.39
I-Oligopeptide-24 yoPhando oluNxulumeneyo
1.Ukulawula ukusebenza kwe-Elastin
Ukulinganisa indima yefiziyoloji ye-endogenous elastin, ilawula ngokubalulekileyo i-elastin synthesis ngaphakathi isikhumba; ukunwebeka kwesikhumba, ukuqina, kunye nehydration zonke ziphuculwe.
Ithishu egayiweyo, imigca emihle egudileyo, kunye neenguqu ezilungileyo ngokubanzi kwi-texture ziziphumo ezithe ngqo zale nkqubo.
Uvuselelo oluthe ngqo lwe iifibroblasts (ukwanda kunye nomsebenzi) kukhokelela ekwandeni kwe-collagen synthesis – esempilweni , ulusu oluselula ngakumbi luyisiphumo sokugqibela.
Ekungeneni kwesikhumba ngeenkqubo zokuhambisa, IiOligopeptides 24 ibophelela kwii-receptors ezithile kwiindawo ze-fibroblast.
Umqondiso we-elastin ulinganisiwe, iindlela ze-intracellular ziyasebenza; i ushicilelo ye-elastin gene ngokwayo yeyona nto kugxilwe kuyo.
Ukuqina kwesikhumba kunye nokuqina kuphuculwe kakhulu, ukubuyisela ukuhla okubhalwe kakuhle (ukufota) kubangela ukuveliswa kwe-elastin yendalo.
Isizukulwana ‘somthombo’ iiproteni yeyona nto ibuyisela ngokwenene ulusu oludala ebutsheni obungakumbi.
2.Yenza i-Fibroblast isebenze kwaye ivuselele i-Collagen Synthesis
Njengoko kukhankanyiwe ngasentla, ukujoliswa ngokuthe ngqo kwe-fibroblasts yenye yeempembelelo eziphambili ze-Oligopeptide 24 uyazama.
Iphucula umsebenzi we-metabolic jikelele we-fibroblasts, ukuvuselela iyantlukwano kunye nokwanda kwabo.
Ikhuthaza ukufudukela ngokukhawuleza kwiindawo ezonakeleyo, ukunyusa umgangatho wabo wokusebenza ekuhlanganiseni i-matrix engaphandle kunye nokukhuthaza ukuveliswa kohlobo olungaphezulu lwe-I kunye ne-III collagen, ukuqinisa ngakumbi isakhelo sokuqina kwesikhumba.
Ukuzilungisa kwesikhumba kunye nobuchule bokuvuselela buphuculwe, kukhokelela kwinkangeleko esempilweni.
3.Ukomeleza iSithintelo solusu kunye noMsebenzi woHlulo
IiOligopeptides 24 ivula i-integrin α6β4→PI3K→umgca we-Akt, ukuvuselela i-keratinocytes ukukhupha i-filaggrin kunye ne-loricrin, kunye nokulawula ukubonakaliswa kweeprotheni eziqinileyo ze-claudin-1 kunye ne-occludin.
Oku komeleza ngokufanelekileyo ukuthembeka kwesakhiwo phakathi kweeseli zedermal kunye ne-epidermal, iphucula umsebenzi wokuthambisa ulusu, kwaye yenza i i-stratum corneum yomelele ngakumbi.
4.I-Antioxidant kunye ne-Post-Procedure Repair
Iintsalela ze-cysteine zibonelela ngamaqela e-sulfhydryl anokuphinda asetyenziswe anikezela ngee-electron kwiiradicals zamahhala, ukukhupha iintlobo zeoksijini esebenzayo.
NgeNrf2/ARE indlela, ibangela ukubonakaliswa kwee-enzymes ezininzi ze-antioxidant (HO-1, SOD2, GCLC); ukuthintela i-lipid peroxidation chain reactions ekhoyo kwiintlobo ezininzi zomonakalo wolusu.
Uphononongo lweklinikhi lubonise ukuhla kwebala lesikhumba (malunga 12%) kunye nokwanda kokukhanya emva kokuqhubekayo 8 ukusetyenziswa kweveki.
I-Cysteine ngokwayo yenza iijeli ze-occlusive zexeshana ezine-aldehydes zasimahla ezikhoyo kwindawo yamanxeba, ngokukhawuleza ukutywina i-microchannels kwaye ngaloo ndlela unciphise umjikelo wokuvuvukala.
Ukulawulwa kwe VEGF kunye ne-TGF-β3 ikhuthaza izicubu zegranulation ukwakheka, ngelixa i-scarfibrotic TGF-β1 ibonakaliso nayo ivinjelwe.
I-COA
HPLC
NKSK
