{"id":7012,"date":"2025-04-02T11:26:46","date_gmt":"2025-04-02T03:26:46","guid":{"rendered":"https:\/\/molchanges.com\/?page_id=7012"},"modified":"2025-07-04T14:49:57","modified_gmt":"2025-07-04T06:49:57","slug":"peptide-glycosylation","status":"publish","type":"page","link":"https:\/\/molchanges.com\/zh\/peptide-glycosylation","title":{"rendered":"\u591a\u80bd\u7cd6\u57fa\u5316"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"7012\" class=\"elementor elementor-7012\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1fecbf7 e-flex e-con-boxed e-con e-parent\" data-id=\"1fecbf7\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1689510 elementor-widget elementor-widget-heading\" data-id=\"1689510\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Peptide Modifications<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5f41f9a elementor-widget__width-initial ekit-equal-height-disable elementor-widget elementor-widget-elementskit-image-box\" data-id=\"5f41f9a\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"elementskit-image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"ekit-wid-con\" >\n            <div class=\"elementskit-info-image-box ekit-image-box text-center simple-card\" >\n\n                \n                <div class=\"elementskit-box-header image-box-img-center\">\n\n                    \n                <\/div>\n                \n                <div class=\"elementskit-box-body ekit-image-box-body\">\n                    <div class=\"elementskit-box-content ekit-image-box-body-inner\">\n                                                <h2 class=\"elementskit-info-box-title\">\n\n                        Peptide Glycosylation\n                        \n                    <\/h2>\n                                                            <div class=\"elementskit-box-style-content\">\n                        Glycopeptides are formed by covalently attaching a sugar molecule to a peptide, a modification that will affect peptide stability, functional positioning, and intercellular interactions.\n\n\n                    <\/div>\n                                    <\/div>\n\n                            <\/div>\n            <\/div>\n    <\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1c27309 e-flex e-con-boxed e-con e-parent\" data-id=\"1c27309\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-482c44d e-con-full e-flex e-con e-child\" data-id=\"482c44d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-597e498 elementor-widget elementor-widget-heading\" data-id=\"597e498\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">What is peptide glycosylation?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b6cd98b elementor-widget elementor-widget-text-editor\" data-id=\"b6cd98b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Peptide glycosylation is the covalent attachment of carbohydrate molecules (glycans) to peptides or proteins to form glycopeptides or glycoproteins. This process takes place mainly through:<\/p><p>N-linked glycosylation: the glycan is bound to an asparagine (Asn) residue with the sequence Asn-X-Ser\/Thr (X\u2260Pro).<\/p><p>O-linked glycosylation: the glycan is attached to a serine (Ser) or threonine (Thr) residue.<\/p><p>Function: Enhances protein stability, aids in proper folding, facilitates intercellular communication, and plays a role in immune responses and disease mechanisms (e.g., cancer biomarkers).<\/p><p>It is commonly found in eukaryotes and some bacteria and is essential for biological processes and biopharmaceutical applications such as antibody drugs.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a335560 e-con-full e-flex e-con e-child\" data-id=\"a335560\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-afa08ec elementor-widget elementor-widget-image\" data-id=\"afa08ec\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"640\" height=\"560\" src=\"https:\/\/molchanges.com\/wp-content\/uploads\/2025\/04\/peptide-glycosylation.webp\" class=\"attachment-full size-full wp-image-7055\" alt=\"peptide glycosylation\" srcset=\"https:\/\/molchanges.com\/wp-content\/uploads\/2025\/04\/peptide-glycosylation.webp 640w, https:\/\/molchanges.com\/wp-content\/uploads\/2025\/04\/peptide-glycosylation-300x263.webp 300w, https:\/\/molchanges.com\/wp-content\/uploads\/2025\/04\/peptide-glycosylation-14x12.webp 14w, https:\/\/molchanges.com\/wp-content\/uploads\/2025\/04\/peptide-glycosylation-600x525.webp 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c6e1e4f e-grid e-con-boxed e-con e-parent\" data-id=\"c6e1e4f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3ba5387 e-con-full e-flex e-con e-child\" data-id=\"3ba5387\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-338dd05 e-con-full e-flex e-con e-child\" data-id=\"338dd05\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-131cd27 elementor-widget elementor-widget-heading\" data-id=\"131cd27\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Common Glycosylated Amino Acids<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0087421 elementor-widget elementor-widget-image-box\" data-id=\"0087421\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">linkage glycosylation<\/h3><p class=\"elementor-image-box-description\">N-linked glycosylation is more common and O-linked glycosylation is more varied, usually occurring on the side chains of Ser, Thr and\/or Asn, but other amino acids can also be glycosylated.<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-db0694f elementor-widget elementor-widget-elementskit-table\" data-id=\"db0694f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"elementskit-table.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"ekit-wid-con\" >\n<div class=\"ekit_table display  ekit_table_data_type-custom\"\n\tdata-settings=\"{&quot;fixedHeader&quot;:false,&quot;search&quot;:false,&quot;search_placeholder&quot;:&quot;&quot;,&quot;responsive&quot;:false,&quot;pagination&quot;:false,&quot;button&quot;:false,&quot;entries&quot;:false,&quot;info&quot;:false,&quot;info_text&quot;:&quot;&quot;,&quot;entries_text&quot;:&quot;&quot;,&quot;ordering&quot;:false,&quot;searchIcon&quot;:&quot;&quot;,&quot;item_per_page&quot;:18,&quot;nav_style&quot;:&quot;&quot;,&quot;prev_text&quot;:&quot;&quot;,&quot;next_text&quot;:&quot;&quot;,&quot;prev_arrow&quot;:&quot;&quot;,&quot;next_arrow&quot;:&quot;&quot;}\">\n\t<table id=\"ekit-table-container-db0694f\" class=\"display dataTable\" style=\"width:100%\"><thead><tr>\t<th class=\"elementor-repeater-item-59fcdc4\">\n\t\t<div\n\t\t\tclass=\"ekit_table_item_container  ekit-table-container- \">\n\t\t\tSugar\t\t<\/div>\n\t<\/th>\n\t\t<th class=\"elementor-repeater-item-f63896e\">\n\t\t<div\n\t\t\tclass=\"ekit_table_item_container  ekit-table-container- \">\n\t\t\tAmino Acid\t\t<\/div>\n\t<\/th>\n\t\t<th class=\"elementor-repeater-item-a4cb9e1\">\n\t\t<div\n\t\t\tclass=\"ekit_table_item_container  ekit-table-container- \">\n\t\t\tGlycated Amino Acid\t\t<\/div>\n\t<\/th>\n\t <\/tr><\/thead><tbody><tr>\t<td data-order=\"\u03b1-D-Galactose\u00a0\"\n\t\tclass=\"elementor-repeater-item-af5665f ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>\u03b1-D-Galactose<\/p><div style=\"position: absolute;left: -45px;top: -8.8px\"><div class=\"gtx-trans-icon\">\u00a0<\/div><\/div>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Serine\u00a0\"\n\t\tclass=\"elementor-repeater-item-c387379 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>Serine<\/p><div style=\"position: absolute;left: -45px;top: -8.8px\"><div class=\"gtx-trans-icon\">\u00a0<\/div><\/div>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Ser(alpha-D-GalNAc)\u00a0\"\n\t\tclass=\"elementor-repeater-item-8fc183c ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>Ser(alpha-D-GalNAc)<\/p><div style=\"position: absolute;left: -45px;top: -8.8px\"><div class=\"gtx-trans-icon\">\u00a0<\/div><\/div>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t<tr>\t<td data-order=\"\u03b1-D-Galactose\"\n\t\tclass=\"elementor-repeater-item-b87319e ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>\u03b1-D-Galactose<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Threonine\"\n\t\tclass=\"elementor-repeater-item-4284b8e ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>Threonine<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Thr(alpha-D-GalNAc)\"\n\t\tclass=\"elementor-repeater-item-d7dab4b ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>Thr(alpha-D-GalNAc)<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t<tr>\t<td data-order=\"\u03b2-D-Galactose\"\n\t\tclass=\"elementor-repeater-item-96310a5 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>\u03b2-D-Galactose<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Serine\"\n\t\tclass=\"elementor-repeater-item-2f24a3a ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>Serine<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Ser(beta-D-GalNAc)\"\n\t\tclass=\"elementor-repeater-item-23a940c ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>Ser(beta-D-GalNAc)<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t<tr>\t<td data-order=\"\u03b2-D-Galactose\"\n\t\tclass=\"elementor-repeater-item-4ad8c7e ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>\u03b2-D-Galactose<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Threonine\"\n\t\tclass=\"elementor-repeater-item-9729768 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>Threonine<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Thr(beta-D-GalNAc)\"\n\t\tclass=\"elementor-repeater-item-813740b ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>Thr(beta-D-GalNAc)<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t<tr>\t<td data-order=\"\u03b2-D-Galactose\"\n\t\tclass=\"elementor-repeater-item-c36e7dd ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>\u03b2-D-Galactose<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Serine\"\n\t\tclass=\"elementor-repeater-item-cfa4004 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>Serine<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Ser(Gal-beta(1-3)GalNAc)\"\n\t\tclass=\"elementor-repeater-item-2918c4d ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>Ser(Gal-beta(1-3)GalNAc)<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t<tr>\t<td data-order=\"\u03b2-D-Glucose\"\n\t\tclass=\"elementor-repeater-item-f5030e1 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>\u03b2-D-Glucose<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Serine\"\n\t\tclass=\"elementor-repeater-item-7686e47 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>Serine<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Ser(beta-D-GlcNAc)\"\n\t\tclass=\"elementor-repeater-item-6503d1d ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>Ser(beta-D-GlcNAc)<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t<tr>\t<td data-order=\"\u03b2-D-Glucose\"\n\t\tclass=\"elementor-repeater-item-b30cd27 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>\u03b2-D-Glucose<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Threonine\"\n\t\tclass=\"elementor-repeater-item-a2ae6d7 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>Threonine<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Thr(beta-D-GlcNAc)\"\n\t\tclass=\"elementor-repeater-item-3299071 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>Thr(beta-D-GlcNAc)<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t<tr>\t<td data-order=\"\u03b2-D-Glucose\"\n\t\tclass=\"elementor-repeater-item-7beae20 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>\u03b2-D-Glucose<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Asparagine\"\n\t\tclass=\"elementor-repeater-item-00c9a38 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>Asparagine<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Asn(beta-D-GlcNAc)\"\n\t\tclass=\"elementor-repeater-item-6432980 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>Asn(beta-D-GlcNAc)<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t<tr>\t<td data-order=\"\u03b2-D-Glucose\"\n\t\tclass=\"elementor-repeater-item-507dc51 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>\u03b2-D-Glucose<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Serine\"\n\t\tclass=\"elementor-repeater-item-0bb604d ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>Serine<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Ser(beta-D-Glc)\"\n\t\tclass=\"elementor-repeater-item-d7c5797 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>Ser(beta-D-Glc)<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t<tr>\t<td data-order=\"\u03b1-D-Mannose\"\n\t\tclass=\"elementor-repeater-item-2bf0b6c ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>\u03b1-D-Mannose<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Serine\"\n\t\tclass=\"elementor-repeater-item-3dff752 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>Serine<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Thr(alpha-D-Man)\"\n\t\tclass=\"elementor-repeater-item-7b500b4 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>Thr(alpha-D-Man)<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t<tr>\t<td data-order=\"\u03b1-D-Mannose\"\n\t\tclass=\"elementor-repeater-item-f0f691d ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>\u03b1-D-Mannose<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Asparagine\"\n\t\tclass=\"elementor-repeater-item-d4e1772 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>Asparagine<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Asn(alpha-D-Man)\"\n\t\tclass=\"elementor-repeater-item-e0488c1 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>Asn(alpha-D-Man)<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t<tr>\t<td data-order=\"\u03b1-D-Mannose\"\n\t\tclass=\"elementor-repeater-item-be6358e ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>\u03b1-D-Mannose<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Serine\"\n\t\tclass=\"elementor-repeater-item-5d93b6d ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>Serine<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Ser(alpha-D-Man)\"\n\t\tclass=\"elementor-repeater-item-9ede99b ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>Ser(alpha-D-Man)<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t<tr>\t<td data-order=\"\u03b1-D-Mannose\"\n\t\tclass=\"elementor-repeater-item-a169607 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>\u03b1-D-Mannose<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Threonine\"\n\t\tclass=\"elementor-repeater-item-563599a ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>Threonine<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Thr(alpha-D-Man)\"\n\t\tclass=\"elementor-repeater-item-fa40c46 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>Thr(alpha-D-Man)<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t <\/tbody><\/table><\/div>\n\n\n\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b44009f e-flex e-con-boxed e-con e-parent\" data-id=\"b44009f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-600c02c e-con-full e-flex e-con e-child\" data-id=\"600c02c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-cb9cef7 e-con-full e-flex e-con e-child\" data-id=\"cb9cef7\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a1eb552 elementor-widget elementor-widget-heading\" data-id=\"a1eb552\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Featured Citations<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a3895f7 elementor-widget elementor-widget-image-box\" data-id=\"a3895f7\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Preparation and preliminary biological evaluation of n-Gluc-Lys([Al18 F]NOTA)-TOCA\u200b<\/h3><p class=\"elementor-image-box-description\">Octreotide and their derivatives can specificially bind with somatostatin receptor (SSTR) which is usually over-expressed on many tumor cells. So 18F labeled octreotide and their derivatives can be used for the diagnosis and evaluation of therapeutic efficacy of SSTR positive tumors. In order to explore a novel PET probe for diagnosis of SSTR positive tumors, the n-Gluc-Lys([Al18F]NOTA)-TOCA was radio-synthesized fast and efficiently using the chelation reaction of n-Gluc-Lys(NOTA)-TOCA with Al18F moiety, n-Gluc-Lys([Al18F]NOTA)-TOCA was a glycosylated octreotide derivative combined with 1, 4, 7-triazacyclononane-1, 4, 7-triacetic acid(NOTA). The labeling efficiency of n-Gluc-Lys([Al18F]NOTA)-TOCA is 69% and the total synthesis time is 25-30 min. The radiochemical purity is over 95% after HLB column purification. The stability in vitro is excellent, and the hydrophilicity is high (lg P = -4.20 \u00b1 0.09(n = 3)). Biodistribution studies in normal mice at 2 h after injection show that the uptake of n-Gluc-Lys([Al18F]NOTA)-TOCA in kidney is high ((13.83 \u00b1 3.52)% ID\/g(n = 5)) and the uptake in liver and bone is low. The uptake in samatostatin pancreas receptor express is high, and the background of blood and muscle is low. These preliminary results provide some experimental basis for further study of Al18F complex labeled octreotide and their analogues as tumor probes for the diagnosis of SSTR-positire tumors. (authors)<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e8a6918 elementor-align-left elementor-widget elementor-widget-button\" data-id=\"e8a6918\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/inis.iaea.org\/records\/ns9sa-aqc28\" rel=\"nofollow noopener\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"icon icon-right-arrow\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Full Article<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e503d8e e-flex e-con-boxed e-con e-parent\" data-id=\"e503d8e\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-4eec54d e-con-full e-flex e-con e-child\" data-id=\"4eec54d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9c17106 elementor-widget elementor-widget-elementskit-heading\" data-id=\"9c17106\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"elementskit-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"ekit-wid-con\" ><div class=\"ekit-heading elementskit-section-title-wraper text_center   ekit_heading_tablet-   ekit_heading_mobile-\"><h2 class=\"ekit-heading--title elementskit-section-title \">Related Peptide Modification Services<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-23c47de e-con-full e-flex e-con e-child\" data-id=\"23c47de\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-13dd3f5 e-con-full e-flex e-con e-child\" data-id=\"13dd3f5\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-410bcce elementor-widget elementor-widget-elementskit-flip-box\" data-id=\"410bcce\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"elementskit-flip-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"ekit-wid-con\" >        <div class=\"ekit-flip-box  box_hover fade_style\">\n            <div class=\"ekit-flip-box-inner\">\n                <div class=\"ekit-flip-box-front \">\n                    <div class=\"ekit-flip-box-inner-wrap\">\n                                                    <h4 class=\"ekit-flip-box-front-title\">peptide glycosylation<\/h4>                                            <\/div>\n                <\/div>\n                <div class=\"ekit-flip-box-back \">\n                    <div class=\"ekit-flip-box-inner-wrap wrap-back\">\n                        <div class=\"ekit-flip-box-back-wrap\">\n                                                            <h4 class=\"ekit-flip-box-back-title\">peptide glycosylation<\/h4>                                                            <p class=\"ekit-flip-box-back-description\">Peptide glycosylation is a covalent modification that can potentially improve the physicochemical properties of peptides<\/p>\n                                                            <a href=\"https:\/\/molchanges.com\/peptide-glycosylation\" class=\"ekit-flip-box-back-button\">\n                                    Read More                                <\/a>\n                                                    <\/div>\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n        <\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6cd8087 e-con-full e-flex e-con e-child\" data-id=\"6cd8087\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-761d0cb elementor-widget elementor-widget-elementskit-flip-box\" data-id=\"761d0cb\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"elementskit-flip-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"ekit-wid-con\" >        <div class=\"ekit-flip-box  box_hover fade_style\">\n            <div class=\"ekit-flip-box-inner\">\n                <div class=\"ekit-flip-box-front \">\n                    <div class=\"ekit-flip-box-inner-wrap\">\n                                                    <h4 class=\"ekit-flip-box-front-title\">peptide Phosphorylation<\/h4>                                            <\/div>\n                <\/div>\n                <div class=\"ekit-flip-box-back \">\n                    <div class=\"ekit-flip-box-inner-wrap wrap-back\">\n                        <div class=\"ekit-flip-box-back-wrap\">\n                                                            <h4 class=\"ekit-flip-box-back-title\">peptide Phosphorylation<\/h4>                                                            <p class=\"ekit-flip-box-back-description\">Phosphoralation may occur on Serine (S, Ser), Threonine (T, Thr) and Tyrosine (Y, Tyr) side chains by phosphoester bond formation<\/p>\n                                                            <a href=\"https:\/\/molchanges.com\/peptide-phosphorylation\" class=\"ekit-flip-box-back-button\">\n                                    Read More                                <\/a>\n                                                    <\/div>\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n        <\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a8b5896 e-con-full e-flex e-con e-child\" data-id=\"a8b5896\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bf69eec elementor-widget elementor-widget-elementskit-flip-box\" data-id=\"bf69eec\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"elementskit-flip-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"ekit-wid-con\" >        <div class=\"ekit-flip-box  box_hover fade_style\">\n            <div class=\"ekit-flip-box-inner\">\n                <div class=\"ekit-flip-box-front \">\n                    <div class=\"ekit-flip-box-inner-wrap\">\n                                                    <h4 class=\"ekit-flip-box-front-title\">Stapled Peptides<\/h4>                                            <\/div>\n                <\/div>\n                <div class=\"ekit-flip-box-back \">\n                    <div class=\"ekit-flip-box-inner-wrap wrap-back\">\n                        <div class=\"ekit-flip-box-back-wrap\">\n                                                            <h4 class=\"ekit-flip-box-back-title\">Stapled Peptides<\/h4>                                                            <p class=\"ekit-flip-box-back-description\">Introduction of two unnatural amino acids containing \u03b1-methyl, \u03b1-alkenyl groups during solid-phase synthesis of peptide chains.<\/p>\n                                                            <a href=\"https:\/\/molchanges.com\/stapled-peptides\" class=\"ekit-flip-box-back-button\">\n                                    Read More                                <\/a>\n                                                    <\/div>\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n        <\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4629cca e-con-full e-flex e-con e-child\" data-id=\"4629cca\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-37f3f79 elementor-widget elementor-widget-elementskit-flip-box\" data-id=\"37f3f79\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"elementskit-flip-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"ekit-wid-con\" >        <div class=\"ekit-flip-box  box_hover fade_style\">\n            <div class=\"ekit-flip-box-inner\">\n                <div class=\"ekit-flip-box-front \">\n                    <div class=\"ekit-flip-box-inner-wrap\">\n                                                    <h4 class=\"ekit-flip-box-front-title\">Cyclic Peptide<\/h4>                                            <\/div>\n                <\/div>\n                <div class=\"ekit-flip-box-back \">\n                    <div class=\"ekit-flip-box-inner-wrap wrap-back\">\n                        <div class=\"ekit-flip-box-back-wrap\">\n                                                            <h4 class=\"ekit-flip-box-back-title\">Cyclic Peptide<\/h4>                                                            <p class=\"ekit-flip-box-back-description\">Peptide cyclisation enhances the conformational stability of peptides (relative to their linear analogues) and is a common strategy in peptide development.\n<\/p>\n                                                            <a href=\"https:\/\/molchanges.com\/cyclic-peptide\" class=\"ekit-flip-box-back-button\">\n                                    Read More                                <\/a>\n                                                    <\/div>\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n        <\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-dcef9aa e-flex e-con-boxed e-con e-parent\" data-id=\"dcef9aa\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2369917 e-con-full e-flex e-con e-child\" data-id=\"2369917\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5c9e470 elementor-widget elementor-widget-image-box\" data-id=\"5c9e470\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">peptide modification<\/h3><p class=\"elementor-image-box-description\">Extensive experience in peptide modification, providing multiple viable avenues for peptide research.<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cb89c43 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"cb89c43\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/molchanges.com\/contact-us\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"icon icon-right-arrow\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Request for quotation<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Peptide Modifications Peptide Glycosylation Glycopeptides are formed by covalently attaching a sugar molecule to a peptide, a modification that will affect peptide stability, functional positioning, and intercellular interactions. What is peptide glycosylation? Peptide glycosylation is the covalent attachment of carbohydrate molecules (glycans) to peptides or proteins to form glycopeptides or glycoproteins. This process takes place [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-7012","page","type-page","status-publish","hentry"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/molchanges.com\/zh\/wp-json\/wp\/v2\/pages\/7012","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/molchanges.com\/zh\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/molchanges.com\/zh\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/molchanges.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/molchanges.com\/zh\/wp-json\/wp\/v2\/comments?post=7012"}],"version-history":[{"count":0,"href":"https:\/\/molchanges.com\/zh\/wp-json\/wp\/v2\/pages\/7012\/revisions"}],"wp:attachment":[{"href":"https:\/\/molchanges.com\/zh\/wp-json\/wp\/v2\/media?parent=7012"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}