{"id":7148,"date":"2025-04-10T16:02:10","date_gmt":"2025-04-10T08:02:10","guid":{"rendered":"https:\/\/molchanges.com\/?page_id=7148"},"modified":"2025-07-04T14:51:10","modified_gmt":"2025-07-04T06:51:10","slug":"peptide-pegylation","status":"publish","type":"page","link":"https:\/\/molchanges.com\/zh\/peptide-pegylation","title":{"rendered":"\u591a\u80bd\u805a\u4e59\u4e8c\u9187\u5316"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"7148\" class=\"elementor elementor-7148\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1fecbf7 e-flex e-con-boxed e-con e-parent\" data-id=\"1fecbf7\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1689510 elementor-widget elementor-widget-heading\" data-id=\"1689510\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">\u591a\u80bd\u4fee\u9970<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5f41f9a elementor-widget__width-initial ekit-equal-height-disable elementor-widget elementor-widget-elementskit-image-box\" data-id=\"5f41f9a\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"elementskit-image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"ekit-wid-con\" >\n            <div class=\"elementskit-info-image-box ekit-image-box text-center simple-card\" >\n\n                \n                <div class=\"elementskit-box-header image-box-img-center\">\n\n                    \n                <\/div>\n                \n                <div class=\"elementskit-box-body ekit-image-box-body\">\n                    <div class=\"elementskit-box-content ekit-image-box-body-inner\">\n                                                <h2 class=\"elementskit-info-box-title\">\n\n                        \u591a\u80bd\u805a\u4e59\u4e8c\u9187\u5316\n                        \n                    <\/h2>\n                                                            <div class=\"elementskit-box-style-content\">\n                        \u805a\u4e59\u4e8c\u9187-\u80bd\u7ed3\u5408\u7269\u7684\u8840\u6db2\u5faa\u73af\u65f6\u95f4\u66f4\u957f\uff0c\u6eb6\u89e3\u5ea6\u66f4\u9ad8\uff0c\u514d\u75ab\u539f\u6027\u66f4\u4f4e\u3002                    <\/div>\n                                    <\/div>\n\n                            <\/div>\n            <\/div>\n    <\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1c27309 e-flex e-con-boxed e-con e-parent\" data-id=\"1c27309\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-482c44d e-con-full e-flex e-con e-child\" data-id=\"482c44d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-597e498 elementor-widget elementor-widget-heading\" data-id=\"597e498\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u4ec0\u4e48\u662f\u591a\u80bd Pegylation\uff1f<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b6cd98b elementor-widget elementor-widget-text-editor\" data-id=\"b6cd98b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u80bd\u805a\u4e59\u4e8c\u9187\u5316\u662f\u5c06\u4e00\u6761\u6216\u591a\u6761\u805a\u4e59\u4e8c\u9187\uff08PEG\uff09\u94fe\u5171\u4ef7\u8fde\u63a5\u5230\u80bd\u5206\u5b50\u4e0a\u7684\u8fc7\u7a0b\u3002\u805a\u4e59\u4e8c\u9187\u5316\u53ef\u4ee5\u589e\u52a0\u80bd\u7684\u5206\u5b50\u91cf\uff0c\u4fdd\u62a4\u80bd\u4e0d\u88ab\u86cb\u767d\u6c34\u89e3\u9176\u6c34\u89e3\uff0c\u5e76\u6700\u7ec8\u6539\u5584\u80bd\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u3002<\/p><p>\u80bd\u5728\u5236\u836f\u4e1a\u548c\u836f\u7269\u6cbb\u7597\u5f00\u53d1\u4e2d\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002\u7136\u800c\uff0c\u7531\u4e8e\u86cb\u767d\u6c34\u89e3\u9176\u7684\u5feb\u901f\u964d\u89e3\u3001\u6eb6\u89e3\u6027\u5dee\u3001\u6297\u539f\u53cd\u5e94\u4ee5\u53ca\u80be\u5c0f\u7403\u6ee4\u8fc7\u7b49\u539f\u56e0\uff0c\u591a\u80bd\u5728\u4f53\u5185\u7684\u5e94\u7528\u53d7\u5230\u4e86\u9650\u5236\u3002\u805a\u4e59\u4e8c\u9187\uff08PEG\uff09\u5171\u4ef7\u8fde\u63a5\u53ef\u964d\u4f4e\u514d\u75ab\u539f\u6027\u3001\u63d0\u9ad8\u6eb6\u89e3\u5ea6\u5e76\u51cf\u5c11\u80be\u810f\u6e05\u9664\u7387\u3002\u6dfb\u52a0\u5355\u5206\u6563 PEG \u94fe\u662f PEG \u5316\u80bd\u6cbb\u7597\u5f00\u53d1\u7684\u5173\u952e\u56e0\u7d20\u3002\u8fd9\u4e9b\u5b89\u5168\u6709\u6548\u7684\u805a\u4e59\u4e8c\u9187\u5316\u80bd\u5bf9\u83b7\u5f97\u6700\u4f73\u7597\u6548\u81f3\u5173\u91cd\u8981\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a335560 e-con-full e-flex e-con e-child\" data-id=\"a335560\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-afa08ec elementor-widget elementor-widget-image\" data-id=\"afa08ec\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"640\" height=\"560\" src=\"https:\/\/molchanges.com\/wp-content\/uploads\/2025\/04\/Peptide-Pegylation-1.webp\" class=\"attachment-full size-full wp-image-7150\" alt=\"\" srcset=\"https:\/\/molchanges.com\/wp-content\/uploads\/2025\/04\/Peptide-Pegylation-1.webp 640w, https:\/\/molchanges.com\/wp-content\/uploads\/2025\/04\/Peptide-Pegylation-1-300x263.webp 300w, https:\/\/molchanges.com\/wp-content\/uploads\/2025\/04\/Peptide-Pegylation-1-14x12.webp 14w, https:\/\/molchanges.com\/wp-content\/uploads\/2025\/04\/Peptide-Pegylation-1-600x525.webp 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c6e1e4f e-grid e-con-boxed e-con e-parent\" data-id=\"c6e1e4f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3ba5387 e-con-full e-flex e-con e-child\" data-id=\"3ba5387\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-338dd05 e-con-full e-flex e-con e-child\" data-id=\"338dd05\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-131cd27 elementor-widget elementor-widget-heading\" data-id=\"131cd27\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u591a\u80bd Pegylation \u79d1\u5b66\u5bb6<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0087421 elementor-widget elementor-widget-image-box\" data-id=\"0087421\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">\u5e38\u89c1 PEG \u8fde\u63a5\u5668\u548c\u7f29\u5199<\/h3><p class=\"elementor-image-box-description\">-\u70b9\u51fb\u5316\u5b66\u53cd\u5e94\uff0c\u5728 PEG \u8bd5\u5242\u7684\u53e0\u6c2e\u57fa\u56e2\u548c\u80bd\u7684\u7094\u57fa\u56e2\u4e4b\u95f4\u53d1\u751f\u5316\u5b66\u53cd\u5e94\uff0c\u53cd\u4e4b\u4ea6\u7136\u3002<br>\n-Suzuki-Miyaura\u5076\u8054\uff0c\u53d1\u751f\u5728 PEG \u8bd5\u5242\u7684\u7898\u82ef\u57fa\u548c\u80bd\u7684\u82b3\u57fa\u787c\u9178\u57fa\u4e4b\u95f4\uff0c\u53cd\u4e4b\u4ea6\u7136\u3002<br>\n-Sonogashira\u5076\u8054\uff0c\u53d1\u751f\u5728 PEG \u8bd5\u5242\u7684\u7898\u82ef\u57fa\u548c\u80bd\u7684\u7094\u57fa\u4e4b\u95f4\uff0c\u53cd\u4e4b\u4ea6\u7136\u3002<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-db0694f elementor-widget elementor-widget-elementskit-table\" data-id=\"db0694f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"elementskit-table.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"ekit-wid-con\" >\n<div class=\"ekit_table display  ekit_table_data_type-custom\"\n\tdata-settings=\"{&quot;fixedHeader&quot;:false,&quot;search&quot;:false,&quot;search_placeholder&quot;:&quot;&quot;,&quot;responsive&quot;:false,&quot;pagination&quot;:false,&quot;button&quot;:false,&quot;entries&quot;:false,&quot;info&quot;:false,&quot;info_text&quot;:&quot;&quot;,&quot;entries_text&quot;:&quot;&quot;,&quot;ordering&quot;:false,&quot;searchIcon&quot;:&quot;&quot;,&quot;item_per_page&quot;:18,&quot;nav_style&quot;:&quot;&quot;,&quot;prev_text&quot;:&quot;&quot;,&quot;next_text&quot;:&quot;&quot;,&quot;prev_arrow&quot;:&quot;&quot;,&quot;next_arrow&quot;:&quot;&quot;}\">\n\t<table id=\"ekit-table-container-db0694f\" class=\"display dataTable\" style=\"width:100%\"><thead><tr>\t<th class=\"elementor-repeater-item-59fcdc4\">\n\t\t<div\n\t\t\tclass=\"ekit_table_item_container  ekit-table-container-\">\n\t\t\t\u7f29\u5199\t\t<\/div>\n\t<\/th>\n\t\t<th class=\"elementor-repeater-item-f63896e\">\n\t\t<div\n\t\t\tclass=\"ekit_table_item_container  ekit-table-container-\">\n\t\t\t\u5168 PEG \u94fe\u540d\u79f0\t\t<\/div>\n\t<\/th>\n\t <\/tr><\/thead><tbody><tr>\t<td data-order=\"PEG\"\n\t\tclass=\"elementor-repeater-item-af5665f ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>PEG<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"tetraethylene glycol\"\n\t\tclass=\"elementor-repeater-item-c387379 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>\u56db\u7518\u9187<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t<tr>\t<td data-order=\"mini-PEG2\"\n\t\tclass=\"elementor-repeater-item-b87319e ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>\u5c0f\u578b PEG2<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"8-amino-3,6-dioxaoctanoic acid\"\n\t\tclass=\"elementor-repeater-item-4284b8e ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>8-\u6c28\u57fa-3,6-\u4e8c\u6c27\u6742\u8f9b\u9178<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t<tr>\t<td data-order=\"mini-PEG3\"\n\t\tclass=\"elementor-repeater-item-96310a5 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>\u5fae\u578b PEG3<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"amino-3,6,9-trioxaundecanoic acid\"\n\t\tclass=\"elementor-repeater-item-2f24a3a ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>\u6c28\u57fa-3,6,9-\u4e09\u6c27\u6742\u5341\u4e00\u70f7\u9178<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t<tr>\t<td data-order=\"NH2-PEG2-acid\"\n\t\tclass=\"elementor-repeater-item-4ad8c7e ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>NH2-PEG2- \u9178<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"3-(2-(2-Aminoethoxy)ethoxy)-propanoic acid\"\n\t\tclass=\"elementor-repeater-item-9729768 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>3-(2-(2-\u6c28\u57fa\u4e59\u6c27\u57fa)\u4e59\u6c27\u57fa)\u4e19\u9178<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t<tr>\t<td data-order=\"PEG750\"\n\t\tclass=\"elementor-repeater-item-c36e7dd ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>PEG750<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Poly(ethylene glycol) methyl ether (average Mn 750)\"\n\t\tclass=\"elementor-repeater-item-cfa4004 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>\u805a\u4e59\u4e8c\u9187\u7532\u919a\uff08\u5e73\u5747\u9530\u542b\u91cf 750<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t<tr>\t<td data-order=\"PEG1000\"\n\t\tclass=\"elementor-repeater-item-f5030e1 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>PEG1000<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Poly(ethylene glycol) methyl ether (average Mn 1000)\"\n\t\tclass=\"elementor-repeater-item-7686e47 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>\u805a\u4e59\u4e8c\u9187\u7532\u919a\uff08\u5e73\u5747\u9530\u542b\u91cf 1000<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t<tr>\t<td data-order=\"PEG2000\"\n\t\tclass=\"elementor-repeater-item-b30cd27 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>PEG2000<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Poly(ethylene glycol) methyl ether (average Mn 2000)\"\n\t\tclass=\"elementor-repeater-item-a2ae6d7 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>\u805a\u4e59\u4e8c\u9187\u7532\u919a\uff08\u5e73\u5747 Mn 2000<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t<tr>\t<td data-order=\"PEG5000\"\n\t\tclass=\"elementor-repeater-item-7beae20 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>PEG5000<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"Poly(ethylene glycol) methyl ether (average Mn 5000)\"\n\t\tclass=\"elementor-repeater-item-00c9a38 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>\u805a\u4e59\u4e8c\u9187\u7532\u919a\uff08\u5e73\u5747 Mn 5000<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t<tr>\t<td data-order=\"Ester (OTBzl)\"\n\t\tclass=\"elementor-repeater-item-507dc51 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>\u916f (OTBzl)<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"p-Nitroanilide\"\n\t\tclass=\"elementor-repeater-item-0bb604d ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>\u5bf9\u785d\u57fa\u82ef\u80fa<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t<tr>\t<td data-order=\"KLH (-COOH of C terminal)\"\n\t\tclass=\"elementor-repeater-item-2bf0b6c ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>KLH\uff08C \u7aef\u7684-COOH\uff09<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t\t<td data-order=\"tBu\"\n\t\tclass=\"elementor-repeater-item-3dff752 ekit_table_data_\">\n\t\t\n\t\t\t<div\n\t\t\t\tclass=\"ekit_table_body_container ekit_table_data_ ekit_body_align_center\">\n\t\t\t\t<p>tBu<\/p>\t\t\t<\/div>\n\n\t\t\t\t<\/td>\n\t <\/tbody><\/table><\/div>\n\n\n\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-793d2db elementor-widget elementor-widget-image\" data-id=\"793d2db\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1000\" height=\"800\" src=\"https:\/\/molchanges.com\/wp-content\/uploads\/2025\/04\/Peptide-Pegylation-MOL-Changes.webp\" class=\"attachment-large size-large wp-image-7151\" alt=\"\" srcset=\"https:\/\/molchanges.com\/wp-content\/uploads\/2025\/04\/Peptide-Pegylation-MOL-Changes.webp 1000w, https:\/\/molchanges.com\/wp-content\/uploads\/2025\/04\/Peptide-Pegylation-MOL-Changes-300x240.webp 300w, https:\/\/molchanges.com\/wp-content\/uploads\/2025\/04\/Peptide-Pegylation-MOL-Changes-768x614.webp 768w, https:\/\/molchanges.com\/wp-content\/uploads\/2025\/04\/Peptide-Pegylation-MOL-Changes-15x12.webp 15w, https:\/\/molchanges.com\/wp-content\/uploads\/2025\/04\/Peptide-Pegylation-MOL-Changes-600x480.webp 600w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b44009f e-flex e-con-boxed e-con e-parent\" data-id=\"b44009f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-600c02c e-con-full e-flex e-con e-child\" data-id=\"600c02c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-cb9cef7 e-con-full e-flex e-con e-child\" data-id=\"cb9cef7\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a1eb552 elementor-widget elementor-widget-heading\" data-id=\"a1eb552\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u7279\u8272\u5f15\u6587<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a3895f7 elementor-widget elementor-widget-image-box\" data-id=\"a3895f7\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">\u5f00\u53d1\u7528\u4e8e\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50 PET \u6210\u50cf\u7684\u653e\u5c04\u6027\u6807\u8bb0\u4e0d\u53ef\u9006\u591a\u80bd\u914d\u4f53<\/h3><p class=\"elementor-image-box-description\">Imaging agents based on peptide probes have desirable pharmacokinetic properties provided that they have high affinities for their target in vivo. An approach to improve a peptide ligand\u2019s affinity for its target is to make this interaction covalent and irreversible. For this purpose, we evaluated a 64Cu-labeled affinity peptide tag, 64Cu-L19K-(5-fluoro-2,4-dinitrobenzene) (64Cu-L19K-FDNB), which binds covalently and irreversibly to vascular endothelial growth factor (VEGF) as a PET imaging agent. We compared the in vivo properties of 64Cu-L19K-FDNB in VEGF-expressing tumor xenografts with its noncovalent binding analogs, 64Cu-L19K-(2,4-dinitrophenyl) (64Cu-L19K-DNP) and 64Cu-L19K. Methods: The L19K peptide (GGNECDIARMWEWECFERK-CONH2) was constructed with 1,4,7-triazacyclononane-1,4,7-triacetic acid at the N terminus for radiolabeling with 64Cu with a polyethylene glycol spacer between peptide and chelate. 1,5-difluoro-2,4-dinitrobenzene was conjugated at the C-terminal lysine for cross-linking to VEGF, resulting in L19K-FDNB. 64Cu-L19K-FDNB was assayed for covalent binding to VEGF in vitro. As a control, L19K was conjugated to 1-fluoro-2,4-dinitrobenzene, resulting in L19K-DNP. PET imaging and biodistribution studies of 64Cu-L19K-FDNB, 64Cu-L19K-DNP, and the native 64Cu-L19K were compared in HCT-116 xenografts. Blocking studies of 64Cu-L19K-FDNB was performed with a coinjection of excess unlabeled L19K-FDNB. Results: In vitro binding studies confirmed the covalent and irreversible binding of 64Cu-L19K-FDNB to VEGF, whereas 64Cu-L19K-DNP and 64Cu-L19K did not bind covalently. PET imaging showed higher tumor uptake with 64Cu-L19K-FDNB than with 64Cu-L19K-DNP and 64Cu-L19K, with mean standardized uptake values of 0.62 \u00b1 0.05, 0.18 \u00b1 0.06, and 0.34 \u00b1 0.14, respectively, at 24 h after injection (P &lt; 0.05), and 0.53 \u00b1 0.05, 0.32 \u00b1 0.14, and 0.30 \u00b1 0.09, respectively, at 48 h after injection (P &lt; 0.05). Blocking studies with 64Cu-L19K-FDNB in the presence of excess unlabeled peptide showed a 53% reduction in tumor uptake at 48 h after injection. Conclusion: In this proof-of-concept study, the use of a covalent binding peptide ligand against VEGF improves tracer accumulation at the tumor site in vivo, compared with its noncovalent binding peptide analogs. This technique is a promising tool to enhance the potency of peptide probes as imaging agents.<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e8a6918 elementor-align-left elementor-widget elementor-widget-button\" data-id=\"e8a6918\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/jnm.snmjournals.org\/content\/55\/6\/1029.long\" rel=\"nofollow noopener\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"icon icon-right-arrow\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">\u5168\u6587<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-012303b e-flex e-con-boxed e-con e-parent\" data-id=\"012303b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-03cdbd3 e-con-full e-flex e-con e-child\" data-id=\"03cdbd3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9b817b3 elementor-widget elementor-widget-elementskit-heading\" data-id=\"9b817b3\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"elementskit-heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"ekit-wid-con\" ><div class=\"ekit-heading elementskit-section-title-wraper text_center   ekit_heading_tablet-   ekit_heading_mobile-\"><h2 class=\"ekit-heading--title elementskit-section-title\">\u76f8\u5173\u591a\u80bd\u4fee\u9970\u670d\u52a1<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-89482e2 e-con-full e-flex e-con e-child\" data-id=\"89482e2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-690aecf e-con-full e-flex e-con e-child\" data-id=\"690aecf\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ca80405 elementor-widget elementor-widget-elementskit-flip-box\" data-id=\"ca80405\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"elementskit-flip-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"ekit-wid-con\" >        <div class=\"ekit-flip-box  box_hover fade_style\">\n            <div class=\"ekit-flip-box-inner\">\n                <div class=\"ekit-flip-box-front\">\n                    <div class=\"ekit-flip-box-inner-wrap\">\n                                                    <h4 class=\"ekit-flip-box-front-title\">\u591a\u80bd\u7cd6\u57fa\u5316<\/h4>                                            <\/div>\n                <\/div>\n                <div class=\"ekit-flip-box-back\">\n                    <div class=\"ekit-flip-box-inner-wrap wrap-back\">\n                        <div class=\"ekit-flip-box-back-wrap\">\n                                                            <h4 class=\"ekit-flip-box-back-title\">\u591a\u80bd\u7cd6\u57fa\u5316<\/h4>                                                            <p class=\"ekit-flip-box-back-description\">\u80bd\u7cd6\u57fa\u5316\u662f\u4e00\u79cd\u5171\u4ef7\u4fee\u9970\uff0c\u6709\u53ef\u80fd\u6539\u5584\u80bd\u7684\u7269\u7406\u5316\u5b66\u7279\u6027<\/p>\n                                                            <a href=\"https:\/\/molchanges.com\/zh\/peptide-glycosylation\/\" class=\"ekit-flip-box-back-button\">\n                                    \u66f4\u591a\u4fe1\u606f                                <\/a>\n                                                    <\/div>\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n        <\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bae5a23 e-con-full e-flex e-con e-child\" data-id=\"bae5a23\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e1271d2 elementor-widget elementor-widget-elementskit-flip-box\" data-id=\"e1271d2\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"elementskit-flip-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"ekit-wid-con\" >        <div class=\"ekit-flip-box  box_hover fade_style\">\n            <div class=\"ekit-flip-box-inner\">\n                <div class=\"ekit-flip-box-front\">\n                    <div class=\"ekit-flip-box-inner-wrap\">\n                                                    <h4 class=\"ekit-flip-box-front-title\">\u591a\u80bd \u78f7\u9178\u5316<\/h4>                                            <\/div>\n                <\/div>\n                <div class=\"ekit-flip-box-back\">\n                    <div class=\"ekit-flip-box-inner-wrap wrap-back\">\n                        <div class=\"ekit-flip-box-back-wrap\">\n                                                            <h4 class=\"ekit-flip-box-back-title\">\u591a\u80bd \u78f7\u9178\u5316<\/h4>                                                            <p class=\"ekit-flip-box-back-description\">\u4e1d\u6c28\u9178\uff08S\uff0cSer\uff09\u3001\u82cf\u6c28\u9178\uff08T\uff0cThr\uff09\u548c\u916a\u6c28\u9178\uff08Y\uff0cTyr\uff09\u4fa7\u94fe\u53ef\u80fd\u4f1a\u901a\u8fc7\u5f62\u6210\u78f7\u916f\u952e\u800c\u53d1\u751f\u78f7\u5316\u4f5c\u7528<\/p>\n                                                            <a href=\"https:\/\/molchanges.com\/zh\/peptide-phosphorylation\/\" class=\"ekit-flip-box-back-button\">\n                                    \u66f4\u591a\u4fe1\u606f                                <\/a>\n                                                    <\/div>\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n        <\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d9715b0 e-con-full e-flex e-con e-child\" data-id=\"d9715b0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8df8316 elementor-widget elementor-widget-elementskit-flip-box\" data-id=\"8df8316\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"elementskit-flip-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"ekit-wid-con\" >        <div class=\"ekit-flip-box  box_hover fade_style\">\n            <div class=\"ekit-flip-box-inner\">\n                <div class=\"ekit-flip-box-front\">\n                    <div class=\"ekit-flip-box-inner-wrap\">\n                                                    <h4 class=\"ekit-flip-box-front-title\">\u9489\u80bd<\/h4>                                            <\/div>\n                <\/div>\n                <div class=\"ekit-flip-box-back\">\n                    <div class=\"ekit-flip-box-inner-wrap wrap-back\">\n                        <div class=\"ekit-flip-box-back-wrap\">\n                                                            <h4 class=\"ekit-flip-box-back-title\">\u9489\u80bd<\/h4>                                                            <p class=\"ekit-flip-box-back-description\">\u5728\u80bd\u94fe\u7684\u56fa\u76f8\u5408\u6210\u8fc7\u7a0b\u4e2d\u5f15\u5165\u4e24\u4e2a\u542b\u6709 \u03b1-\u7532\u57fa\u3001\u03b1-\u70ef\u57fa\u7684\u975e\u5929\u7136\u6c28\u57fa\u9178\u3002<\/p>\n                                                            <a href=\"https:\/\/molchanges.com\/zh\/stapled-peptides\/\" class=\"ekit-flip-box-back-button\">\n                                    \u66f4\u591a\u4fe1\u606f                                <\/a>\n                                                    <\/div>\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n        <\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-349e66c e-con-full e-flex e-con e-child\" data-id=\"349e66c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-39dfcf0 elementor-widget elementor-widget-elementskit-flip-box\" data-id=\"39dfcf0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"elementskit-flip-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"ekit-wid-con\" >        <div class=\"ekit-flip-box  box_hover fade_style\">\n            <div class=\"ekit-flip-box-inner\">\n                <div class=\"ekit-flip-box-front\">\n                    <div class=\"ekit-flip-box-inner-wrap\">\n                                                    <h4 class=\"ekit-flip-box-front-title\">\u73af\u80bd<\/h4>                                            <\/div>\n                <\/div>\n                <div class=\"ekit-flip-box-back\">\n                    <div class=\"ekit-flip-box-inner-wrap wrap-back\">\n                        <div class=\"ekit-flip-box-back-wrap\">\n                                                            <h4 class=\"ekit-flip-box-back-title\">\u73af\u80bd<\/h4>                                                            <p class=\"ekit-flip-box-back-description\">\u80bd\u73af\u5316\u53ef\u589e\u5f3a\u80bd\u7684\u6784\u8c61\u7a33\u5b9a\u6027\uff08\u76f8\u5bf9\u4e8e\u5176\u7ebf\u6027\u7c7b\u4f3c\u7269\u800c\u8a00\uff09\uff0c\u662f\u80bd\u5f00\u53d1\u4e2d\u7684\u4e00\u79cd\u5e38\u89c1\u7b56\u7565\u3002\n<\/p>\n                                                            <a href=\"https:\/\/molchanges.com\/zh\/cyclic-peptide\/\" class=\"ekit-flip-box-back-button\">\n                                    \u66f4\u591a\u4fe1\u606f                                <\/a>\n                                                    <\/div>\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n        <\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-dcef9aa e-flex e-con-boxed e-con e-parent\" data-id=\"dcef9aa\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2369917 e-con-full e-flex e-con e-child\" data-id=\"2369917\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5c9e470 elementor-widget elementor-widget-image-box\" data-id=\"5c9e470\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">\u80bd\u4fee\u9970<\/h3><p class=\"elementor-image-box-description\">\u5728\u591a\u80bd\u4fee\u9970\u65b9\u9762\u7ecf\u9a8c\u4e30\u5bcc\uff0c\u4e3a\u591a\u80bd\u7814\u7a76\u63d0\u4f9b\u4e86\u591a\u79cd\u53ef\u884c\u7684\u9014\u5f84\u3002<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cb89c43 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"cb89c43\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/molchanges.com\/zh\/contact-us\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"icon icon-right-arrow\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">\u8be2\u4ef7<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Peptide Modifications Peptide Pegylation Polyethylene glycol-peptide conjugates have a longer blood circulation time, higher solubility and lower immunogenicity. What is Peptide Pegylation? Peptide polyethylene glycolisation is the process of covalently attaching one or more polyethylene glycol (PEG) chains to a peptide molecule. Polyethylene glycolisation increases the molecular weight of the peptide, protects the peptide from [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-7148","page","type-page","status-publish","hentry"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/molchanges.com\/zh\/wp-json\/wp\/v2\/pages\/7148","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/molchanges.com\/zh\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/molchanges.com\/zh\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/molchanges.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/molchanges.com\/zh\/wp-json\/wp\/v2\/comments?post=7148"}],"version-history":[{"count":0,"href":"https:\/\/molchanges.com\/zh\/wp-json\/wp\/v2\/pages\/7148\/revisions"}],"wp:attachment":[{"href":"https:\/\/molchanges.com\/zh\/wp-json\/wp\/v2\/media?parent=7148"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}