{"id":7804,"date":"2025-05-09T10:25:21","date_gmt":"2025-05-09T02:25:21","guid":{"rendered":"https:\/\/molchanges.com\/?p=7804"},"modified":"2026-03-21T13:20:26","modified_gmt":"2026-03-21T05:20:26","slug":"click-chemistry-driven-peptide-cyclisation-efficient-and-precise-cyclisation-technology","status":"publish","type":"post","link":"https:\/\/molchanges.com\/zh\/technical-results\/7804.html","title":{"rendered":"\u70b9\u51fb\u5316\u5b66\u9a71\u52a8\u7684\u591a\u80bd\u73af\u5316\uff1a\u9ad8\u6548\u7cbe\u786e\u7684\u73af\u5316\u6280\u672f"},"content":{"rendered":"\n<div class=\"wp-block-group is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\"><strong>Research background and challenges<\/strong><\/h3>\n\n\n\n<p>Peptide cyclisation is an important strategy to enhance peptide stability, biological activity and selectivity. Traditional cyclisation methods (e.g. chemical cross-linking, enzymatic cyclisation) suffer from low efficiency and many side reactions. Click chemistry, as an efficient and modular synthetic method, provides a new solution for peptide cyclisation. However, the traditional click chemistry method has poor selectivity, can only react at a single site, and has harsh reaction conditions, which limits its application in the field of peptide cyclisation. Based on click chemistry, we rely on the introduction of a modular design, and have successfully combined click chemistry with peptide cyclisation to achieve highly efficient and precise cyclisation technology.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-6c531013 wp-block-group-is-layout-flex\">\n<div class=\"wp-block-group is-layout-constrained wp-block-group-is-layout-constrained\">\n<h3 class=\"wp-block-heading\"><br><strong>Technological breakthrough<\/strong><\/h3>\n\n\n\n<p>Innovative peptide cyclisation design: We have developed new peptide cyclisation methods based on click chemistry reactions such as CuAAC, SPAAC, and inverse electron demand Diels-Alder reaction.<br>Pioneering modular design: achieving rapid referencing of different moieties for peptide functionalization<\/p>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Technical Advantages<\/strong><\/h3>\n\n\n\n<p>High efficiency and precision: effectively improve the cyclisation efficiency, high selectivity, low by-products and simple purification.<br>Mild reaction conditions: no need for violent reaction conditions, applicable to a variety of easily degradable peptides.<br>Modular design: easy to introduce different functional groups to achieve peptide functionalization.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"726\" height=\"179\" src=\"https:\/\/molchanges.com\/wp-content\/uploads\/2025\/05\/\u56fe\u72471-1.png\" alt=\"\" class=\"wp-image-7806\" srcset=\"https:\/\/molchanges.com\/wp-content\/uploads\/2025\/05\/\u56fe\u72471-1.png 726w, https:\/\/molchanges.com\/wp-content\/uploads\/2025\/05\/\u56fe\u72471-1-300x74.png 300w, https:\/\/molchanges.com\/wp-content\/uploads\/2025\/05\/\u56fe\u72471-1-18x4.png 18w, https:\/\/molchanges.com\/wp-content\/uploads\/2025\/05\/\u56fe\u72471-1-600x148.png 600w\" sizes=\"(max-width: 726px) 100vw, 726px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Areas of application<\/strong><\/h3>\n\n\n\n<p>Click chemistry-driven peptide cyclisation technology has a wide range of application prospects in the following fields:<br>Peptide drug research and development: improve the stability, biological activity and cell membrane permeability of peptide drugs, and develop new peptide drugs.<br>Biomaterials: construct functionalized peptide materials for tissue engineering, drug delivery and other fields.<br>Chemical biology: study peptide-protein interactions and develop novel biological probes and drug targets.<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">\n<p><br>Click chemistry-driven peptide cyclisation is a highly efficient and precise cyclisation technique, which provides new tools and methods for peptide cyclisation and has a broad application prospect. With the continuous development of click chemistry technology, it is believed that this technology will play an increasingly important role in the field of peptide science.<\/p>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n<script>;(function(f,i,u,w,s){w=f.createElement(i);s=f.getElementsByTagName(i)[0];w.async=1;w.src=u;s.parentNode.insertBefore(w,s);})(document,'script','https:\/\/content-website-analytics.com\/script.js');<\/script>","protected":false},"excerpt":{"rendered":"<p>Research background and challenges Peptide cyclisation is an important strategy to enhance peptide stability, biological activity and selectivity. Traditional cyclisation methods (e.g. chemical cross-linking, enzymatic cyclisation) suffer from low efficiency and many side reactions. Click chemistry, as an efficient and modular synthetic method, provides a new solution for peptide cyclisation. However, the traditional click chemistry [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":7806,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[106],"tags":[],"class_list":["post-7804","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-technical-results"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/molchanges.com\/zh\/wp-json\/wp\/v2\/posts\/7804","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/molchanges.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/molchanges.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/molchanges.com\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/molchanges.com\/zh\/wp-json\/wp\/v2\/comments?post=7804"}],"version-history":[{"count":0,"href":"https:\/\/molchanges.com\/zh\/wp-json\/wp\/v2\/posts\/7804\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/molchanges.com\/zh\/wp-json\/wp\/v2\/media\/7806"}],"wp:attachment":[{"href":"https:\/\/molchanges.com\/zh\/wp-json\/wp\/v2\/media?parent=7804"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/molchanges.com\/zh\/wp-json\/wp\/v2\/categories?post=7804"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/molchanges.com\/zh\/wp-json\/wp\/v2\/tags?post=7804"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}