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4.992-17.28V320h128v234.688l4.992 17.28 43.456 68.032h58.432l26.944 14.72zM320 896H192v128H128v-128H0v-64h128v-128h64v128h128z\" fill=\"#86d2e9\" data-spm-anchor-id=\"a313x.search_index.0.i31.7a773a81Yn5fO8\" class=\"\"><\/path><path d=\"M256 128l-32 32L192 128V0h64zM88.256 43.008l-45.248 45.248 90.496 90.496h44.8v-45.504zM0 192v64h128l32-32L128 192z m43.008 167.744l45.248 45.248 90.496-90.496v-44.8h-45.504zM192 448h64V320l-32-32L192 320z m167.744-43.008l45.248-45.248-90.496-90.496h-44.8v45.504zM448 256V192H320l-32 32 32 32z m-43.008-167.744L359.744 43.008 269.248 133.504v44.8h45.504z\" fill=\"#515151\" data-spm-anchor-id=\"a313x.search_index.0.i33.7a773a81Yn5fO8\" class=\"selected\"><\/path><\/svg>\t\t<\/span>\n\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tliterature\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t\t<\/div>\n\t\t\t<div class=\"e-n-tabs-content\">\n\t\t\t\t<div id=\"e-n-tab-content-1344307691\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-1344307691\" data-tab-index=\"1\" style=\"--n-tabs-title-order: 1;\" class=\"e-active elementor-element elementor-element-5de9dc5a e-con-full e-flex e-con e-child\" data-id=\"5de9dc5a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-635f38f8 e-flex e-con-boxed e-con e-child\" data-id=\"635f38f8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-170c2f24 elementor-drop-cap-yes elementor-drop-cap-view-default elementor-widget elementor-widget-text-editor\" data-id=\"170c2f24\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;drop_cap&quot;:&quot;yes&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Cardiogen is a synthetic bioactive peptide with demonstrated cardiovascular protective effects and restorative potential. Derived from continuous human research into the <a href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/pathogenesis\"><strong>pathogenesis<\/strong><\/a> of cardiovascular diseases, it is a fully synthetic peptide drug.<\/p><p>Cardiovascular protection, or more broadly <a href=\"https:\/\/en.wikipedia.org\/wiki\/Cardioprotection\"><strong>cardioprotection<\/strong><\/a> in living organisms, involves the transmission of specific signaling pathways; hormones and neurotransmitters are the primary mediators.<\/p><p>Cardiogen was designed from the outset to either mimic these pathways or directly activate key downstream signaling protein(s) to achieve said protection.<\/p><p>Not being a naturally extracted drug, all the inherent limitations associated with natural peptides (rapid degradation, short half-life, low <a href=\"https:\/\/en.wikipedia.org\/wiki\/Bioavailability\"><strong>bioavailability<\/strong><\/a>) are overcome to a significant degree.<\/p><p>Preclinical studies have demonstrated significant reductions in <a href=\"https:\/\/en.wikipedia.org\/wiki\/Myocardial_infarction\"><strong>myocardial infarct<\/strong><\/a> size, improved left ventricular function, prevention of adverse <a href=\"https:\/\/en.wikipedia.org\/wiki\/Ventricular_remodeling\"><strong>ventricular remodeling<\/strong><\/a>, and protection against both apoptosis and <a href=\"https:\/\/www.sciencedirect.com\/topics\/agricultural-and-biological-sciences\/necrosis\"><strong>necrosis<\/strong><\/a> of cardiomyocytes.<\/p><p>A potent antioxidant capacity is also exhibited, mitigating all forms of oxidative damage specific to either <a href=\"https:\/\/www.sciencedirect.com\/topics\/engineering\/cardiomyocytes\"><strong>cardiomyocytes<\/strong><\/a> or the accompanying vascular endothelial cells.<\/p><p>Recent studies point towards enhancing myocardial energy metabolism &#8211; optimization of mitochondrial function and energy production being of particular interest.<\/p><p>Anti-fibrotic effects are currently being investigated.<\/p><p>Multidimensional, synergistic cardioprotective and therapeutic potential is what Cardiogen represents.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-1344307692\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-1344307692\" data-tab-index=\"2\" style=\"--n-tabs-title-order: 2;\" class=\" elementor-element elementor-element-7be91698 e-con-full e-flex e-con e-child\" data-id=\"7be91698\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-615d66a3 e-flex e-con-boxed e-con e-child\" data-id=\"615d66a3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d31e984 elementor-position-inline-start elementor-mobile-position-inline-start elementor-view-default 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class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tCAS Number\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\t\/\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3d29edc7 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"3d29edc7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-457a0414 elementor-position-inline-start elementor-mobile-position-inline-start elementor-view-default elementor-widget elementor-widget-icon-box\" 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Formula\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tC18H31N7O9\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6428affe elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"6428affe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5cd20c1 elementor-position-inline-start elementor-mobile-position-inline-start elementor-view-default elementor-widget elementor-widget-icon-box\" data-id=\"5cd20c1\" data-element_type=\"widget\" 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36.127364-73.013307 111.226766-36.885944 167.740962 36.127364 56.514196 111.226766 73.013307 167.740962 36.885944 34.894672-22.283282 56.040084-60.87603 56.040084-102.408276v-6.258283l61.824255-16.783578z\" fill=\"#515151\" data-spm-anchor-id=\"a313x.search_index.0.i169.7b0e3a8118k0Gw\" class=\"selected\"><\/path><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h5 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tMolecular Weight\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\t489.486\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-1344307693\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-1344307693\" data-tab-index=\"3\" style=\"--n-tabs-title-order: 3;\" class=\" elementor-element elementor-element-7881cd4f e-con-full e-flex e-con e-child\" data-id=\"7881cd4f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-62fcaecf e-flex e-con-boxed e-con e-child\" data-id=\"62fcaecf\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-70cd8fb3 elementor-widget elementor-widget-text-editor\" data-id=\"70cd8fb3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4>Research Of Cardiogen Peptide<\/h4><h5>1.Treating cardiovascular diseases and subsequent <a href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/reperfusion-injury\"><strong>reperfusion injury<\/strong><\/a><\/h5><p>Reperfusion injury itself is the end point many currently seek to treat.<\/p><p>Blockages within the cardiovascular system lead to<strong><a href=\"https:\/\/en.wikipedia.org\/wiki\/Ischemia\"> ischemia<\/a><\/strong>\/<a href=\"https:\/\/en.wikipedia.org\/wiki\/Hypoxia_(medicine)\"><strong>hypoxia<\/strong> <\/a>of the myocardium; direct restoration of blood flow (surgical or otherwise) causes this severe damage.<\/p><p>Cardiogen, through activation of the previously mentioned intracellular pathways (<a href=\"https:\/\/www.cellsignal.com\/pathways\/pathways-akt-signaling?srsltid=AfmBOoqLiw8R-2BlEiUMJihI2L0O4sQ0VlzPeyaU9gIyiQ0wvoDrdwPH\"><strong>PI3K-Ak<\/strong><\/a>t being prime among them), mimics the body&#8217;s own endogenous protective responses.<\/p><p>Opening of the <strong><a href=\"https:\/\/www.sciencedirect.com\/topics\/biochemistry-genetics-and-molecular-biology\/mitochondrial-permeability-transition-pore\">mitochondrial permeability transition pore(mPTP)<\/a><\/strong>\u00a0being one of the last, irreversibly damaging steps in cardiomyocyte death, is successfully inhibited.<\/p><p>Rescuing the patient from full or near full <a href=\"https:\/\/en.wikipedia.org\/wiki\/Infarction\"><strong>infarction<\/strong><\/a> is the ideal end result &#8211; smaller, more &#8216;normal&#8217; sized myocardium and all that follows, is the true goal of cardiogenic therapy.<\/p><h5>2.Inhibiting apoptosis<\/h5><p>In models of chronic cardiac stress and reperfusion injury, cardiogen have been demonstrated to significantly suppress apoptosis.<\/p><p>They directly activate key <a href=\"https:\/\/www.sciencedirect.com\/topics\/biochemistry-genetics-and-molecular-biology\/kinase\"><strong>kinases<\/strong><\/a> such as Akt, inhibit pro-apoptotic protein activity via <a href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/phosphorylation\"><strong>phosphorylation<\/strong><\/a>, and in some cases enhance anti-apoptotic protein activity.<\/p><p>A form of direct hormonal-level suppression of apoptosis is achieved through these mechanisms.<\/p><p>This research indicates significant potential for cardiogen &#8211; rescuing critically ill cardiac patients being one application, regulating various aspects of chronic heart disease, slowing (if not stopping) the loss of myocardial cells, and by extension delaying all forms of progressive heart failure.<\/p><h5>3.Improving cardiac energy metabolism<\/h5><p>Cardiogens enhance energy metabolism within cardiac cells; front-end inhibition of mPTP opening is a primary method used for this purpose.<\/p><p>Reducing oxidative damage to the mitochondrial electron transport chain allows the mitochondria to maintain both membrane potential and to a large degree structural integrity.<\/p><p>Efficient <a href=\"https:\/\/www.physio-pedia.com\/Adenosine_triphosphate_(ATP)\"><strong>adenosine triphosphate (ATP)<\/strong><\/a> production is then possible, a constant sustainable form of energy being supplied to the failing heart.<\/p><p>Stable cardiac contractility and all related forms of short\/long term cardiac function depend upon this stable energy supply.<\/p><h5>4.Antioxidant and Anti-inflammatory Effects<\/h5><p>Indirect antioxidant effects are also exhibited by cardiogen.<\/p><p>Direct activation of certain signaling pathways (Akt being the prime example) leads to upregulation of the body&#8217;s endogenous antioxidant systems.<\/p><p><a href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/glutathione-peroxidase\"><strong>Glutathione peroxidase<\/strong><\/a> and other similar enzymes see increased expression, creating a more &#8216;favorable&#8217; environment for cardiovascular cells.<\/p><p>Inhibition of Myocardial Fibrosis and Ventricular Remodeling: Cardiac fibrosis itself is a primary cause of acute heart disease or eventual organ failure.<\/p><p>Prolonged stress induced fibrosis and subsequent ventricular remodeling are at least partially responsible for the end stage of heart disease.<\/p><p>Cardiogen action on 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-4.10207 l -26.6028 -40.6323 a 9.1265 9.1265 0 0 1 2.59717 -12.5489 a 9.24786 9.24786 0 0 1 4.97588 -1.48063 c 2.93698 0 5.75261 1.48063 7.35459 4.05353 l 26.6028 40.6323 a 9.15077 9.15077 0 0 1 -2.59717 12.5974 Z\" fill=\"#86d2e9\" data-spm-anchor-id=\"a313x.search_index.0.i2.5b1c3a81rnqbFB\" class=\"\"><\/path><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tMS\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-1344307695\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-1344307695\" data-tab-index=\"5\" style=\"--n-tabs-title-order: 5;\" class=\" elementor-element elementor-element-4da18a7d e-flex e-con-boxed e-con e-child\" data-id=\"4da18a7d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-1f1598cd e-con-full e-flex e-con e-child\" data-id=\"1f1598cd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-58ac42c6 elementor-widget elementor-widget-text-editor\" data-id=\"58ac42c6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/doi.org\/10.1007\/s10517-010-0730-9\"><strong>(1).Levdik, N. V.; Knyazkin, I. V. Tumor-modifying effect of cardiogen peptide on M-1 sarcoma in senescent rats. <em>Bull Exp Biol Med <\/em>2009, <em>148<\/em>(3), 433-436. DOI: 10.1007\/s10517-010-0730-9 \u00a0From NLM Medline.<\/strong><\/a><\/p><p><a href=\"https:\/\/doi.org\/10.1007\/s10354-008-0565-4\"><strong>(2).Ferrari, J.; Flamm-Horak, A.; Lischka-Lindner, A.; Knoflach, M.; Schnabl, S.; Lang, W. [Worsening in patients treated in acute stroke units&#8211;results of the Austrian Stroke Unit Registry]. <em>Wien Med Wochenschr <\/em>2008, <em>158<\/em>(15-16), 425-428. DOI: 10.1007\/s10354-008-0565-4 \u00a0From NLM Medline.<\/strong><\/a><\/p><p><a href=\"https:\/\/doi.org\/10.1007\/s00441-016-2431-9\"><strong>(3).Talman, V.; Ruskoaho, H. Cardiac fibrosis in myocardial infarction-from repair and remodeling to regeneration. <em>Cell Tissue Res <\/em>2016, <em>365<\/em>(3), 563-581. DOI: 10.1007\/s00441-016-2431-9 \u00a0From NLM Medline.<\/strong><\/a><\/p><p><a href=\"https:\/\/doi.org\/10.1002\/jcp.26243\"><strong>(4).Zhou, D. C.; Su, Y. H.; Jiang, F. Q.; Xia, J. B.; Wu, H. Y.; Chang, Z. S.; Peng, W. T.; Song, G. H.; Park, K. S.; Kim, S. K.; et al. CpG oligodeoxynucleotide preconditioning improves cardiac function after myocardial infarction via modulation of energy metabolism and angiogenesis. <em>J Cell Physiol <\/em>2018, <em>233<\/em>(5), 4245-4257. DOI: 10.1002\/jcp.26243 \u00a0From NLM Medline.<\/strong><\/a><\/p><p><a href=\"https:\/\/doi.org\/10.1016\/j.intimp.2021.108393\"><strong>(5).Zhu, Y. L.; Huang, J.; Chen, X. Y.; Xie, J.; Yang, Q.; Wang, J. F.; Deng, X. M. Senkyunolide I alleviates renal Ischemia-Reperfusion injury by inhibiting oxidative stress, endoplasmic reticulum stress and apoptosis. <em>Int Immunopharmacol <\/em>2022, <em>102<\/em>, 108393. 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