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4.992-17.28V320h128v234.688l4.992 17.28 43.456 68.032h58.432l26.944 14.72zM320 896H192v128H128v-128H0v-64h128v-128h64v128h128z\" fill=\"#86d2e9\" data-spm-anchor-id=\"a313x.search_index.0.i31.7a773a81Yn5fO8\" class=\"\"><\/path><path d=\"M256 128l-32 32L192 128V0h64zM88.256 43.008l-45.248 45.248 90.496 90.496h44.8v-45.504zM0 192v64h128l32-32L128 192z m43.008 167.744l45.248 45.248 90.496-90.496v-44.8h-45.504zM192 448h64V320l-32-32L192 320z m167.744-43.008l45.248-45.248-90.496-90.496h-44.8v45.504zM448 256V192H320l-32 32 32 32z m-43.008-167.744L359.744 43.008 269.248 133.504v44.8h45.504z\" fill=\"#515151\" data-spm-anchor-id=\"a313x.search_index.0.i33.7a773a81Yn5fO8\" class=\"selected\"><\/path><\/svg>\t\t<\/span>\n\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\t\u6587\u732e\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t\t<\/div>\n\t\t\t<div class=\"e-n-tabs-content\">\n\t\t\t\t<div id=\"e-n-tab-content-19731805201\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-19731805201\" data-tab-index=\"1\" style=\"--n-tabs-title-order: 1;\" class=\"e-active elementor-element elementor-element-29d7d5f2 e-con-full e-flex e-con e-child\" data-id=\"29d7d5f2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-4e527539 e-flex e-con-boxed e-con e-child\" data-id=\"4e527539\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-56dd30a3 elementor-drop-cap-yes elementor-drop-cap-view-default elementor-widget elementor-widget-text-editor\" data-id=\"56dd30a3\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;drop_cap&quot;:&quot;yes&quot;,&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Epithalon is a bioactive <a href=\"https:\/\/en.wikipedia.org\/wiki\/Tetrapeptide\" rel=\"nofollow noopener\" target=\"_blank\"><strong>tetrapeptide<\/strong><\/a> discovered and refined through functional studies of the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Pineal_gland\" rel=\"nofollow noopener\" target=\"_blank\"><strong>pineal gland<\/strong><\/a>. The specific amino acid sequence is Ala-Glu-Asp-Gly.<\/p><p>During the 1980s, Russian scientists carried out systematic research into the pineal gland&#8217;s regulatory role within various biological aging processes. Bioactive <a href=\"https:\/\/en.wikipedia.org\/wiki\/Small_molecule\" rel=\"nofollow noopener\" target=\"_blank\"><strong>small-molecule<\/strong><\/a> peptide fragments were isolated and characterized as part of this work;<br \/>Epithalon itself was developed from one such active fragment. Optimization of this peptide led to its successful artificial synthesis.<\/p><p>Belonging to the more defined category of bioregulatory peptides, Epithalon specifically recognizes certain forms of <a href=\"https:\/\/en.wikipedia.org\/wiki\/Gene_expression\" rel=\"nofollow noopener\" target=\"_blank\"><strong>gene expression<\/strong><\/a> and subsequent <a href=\"https:\/\/training.seer.cancer.gov\/anatomy\/cells_tissues_membranes\/cells\/function.html\" rel=\"nofollow noopener\" target=\"_blank\"><strong>cellular functions<\/strong><\/a>.<br \/>Extensive in vivo and various types of in vitro experiments have shown that it uniquely activates the expression of <a href=\"https:\/\/en.wikipedia.org\/wiki\/Telomerase_reverse_transcriptase\" rel=\"nofollow noopener\" target=\"_blank\"><strong>telomerase reverse transcriptase (TERT)<\/strong><\/a> &#8211; the catalytic subunit of telomerase &#8211; which is a near universal core mechanism of <a href=\"https:\/\/www.sciencedirect.com\/topics\/biochemistry-genetics-and-molecular-biology\/cell-aging\" rel=\"nofollow noopener\" target=\"_blank\"><strong>cellular aging<\/strong><\/a>.<\/p><p><a href=\"https:\/\/en.wikipedia.org\/wiki\/Telomerase\" rel=\"nofollow noopener\" target=\"_blank\"><strong>Telomerase<\/strong><\/a> synthesizes (and to a large extent compensates for) the loss of telomere length at <a href=\"https:\/\/en.wikipedia.org\/wiki\/Chromosome\" rel=\"nofollow noopener\" target=\"_blank\"><strong>chromosome<\/strong><\/a> ends; repeated <a href=\"https:\/\/en.wikipedia.org\/wiki\/Cell_division\" rel=\"nofollow noopener\" target=\"_blank\"><strong>cell division<\/strong><\/a> causes this loss. Extending telomere length directly improves the in vitro replication limits of cells, slowing all associated &#8216;signs&#8217; of true cellular aging.<\/p><p>Animal models have demonstrated significant effects from Epithalon: biological lifespan extension, at least partial reversal of age-related physiological decline, immune system regulation, inhibition of (some) tumorigenesis, and to a point endocrine balance restoration.<\/p><p>Modifying key gene expressions and possessing (to some degree) antioxidant properties are believed to be the underlying causes of all of the above. 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class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2106b96 elementor-position-inline-start elementor-mobile-position-inline-start elementor-view-default elementor-widget elementor-widget-icon-box\" data-id=\"2106b96\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" class=\"icon\" viewbox=\"0 0 1242 1024\" width=\"155.25\" height=\"128\"><path d=\"M881.892257 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>\n\t\t\t\t\t\t\t\u5206\u5b50\u91cf\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\t390.35\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-19731805203\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-19731805203\" data-tab-index=\"3\" style=\"--n-tabs-title-order: 3;\" class=\"elementor-element elementor-element-5c9b7010 e-con-full e-flex e-con e-child\" data-id=\"5c9b7010\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-49752406 e-flex e-con-boxed e-con e-child\" data-id=\"49752406\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-18cc051 elementor-widget elementor-widget-text-editor\" data-id=\"18cc051\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4>Research Of Epithalon<\/h4><h5><strong><b>1.Anti-aging Effects<\/b><\/strong><\/h5><p>Telomeres are specialized DNA-protein complexes located at the ends of <a href=\"https:\/\/www.visiblebody.com\/learn\/biology\/dna-chromosomes\/eukaryotic-chromosomes\" rel=\"nofollow noopener\" target=\"_blank\"><strong>eukaryotic chromosomes<\/strong><\/a>. Their primary function is shielding chromosome ends from being recognized as DNA damage; preventing any form of chromosomal degradation is of great importance. Each cell division results in a slight shortening of these telomeres.<\/p><p>Reaching a minimal length triggers replicative <a href=\"https:\/\/en.wikipedia.org\/wiki\/Senescence\" rel=\"nofollow noopener\" target=\"_blank\"><strong>senescence<\/strong><\/a> or various DNA damage response mechanisms; arrest of cell division (specifically at the <a href=\"https:\/\/en.wikipedia.org\/wiki\/G1_phase\" rel=\"nofollow noopener\" target=\"_blank\"><strong>G1 phase<\/strong><\/a>) and the subsequent secretion of several hormones associated with cellular aging is the end result.<\/p><p>Telomerase, a <a href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/ribonucleoprotein\" rel=\"nofollow noopener\" target=\"_blank\"><strong>ribonucleoprotein<\/strong><\/a> reverse transcriptase, promotes the synthesis of this telomere DNA and adding it back to the end of the chromosome &#8211; compensating for the previous shortening. Epithalon specifically activates the TERT gene responsible for this activity, fundamentally regulating telomerase.<\/p><p>Animal model studies have shown periodic injections to significantly extend lifespan, delay multiple aspects of age-related physiological decline, reduce (near complete <a href=\"https:\/\/en.wikipedia.org\/wiki\/Elimination\" rel=\"nofollow noopener\" target=\"_blank\"><strong>elimination<\/strong><\/a>) various pathologies of aging, and all around modulating key senescence pathways.<\/p><h5><strong><b>2.Antioxidant and anti-inflammatory effects<\/b><\/strong><\/h5><p>Drosophila melanogaster is a well established model for evaluating <a href=\"https:\/\/en.wikipedia.org\/wiki\/Lipid_peroxidation\" rel=\"nofollow noopener\" target=\"_blank\"><strong>lipid peroxidation<\/strong><\/a> levels. During the larval stage the addition of 0.00001% Epithalon successfully inhibited the expected increase in said peroxidation. Potent antioxidant and to a large extent anti-inflammatory effects are indicated by this result.<\/p><p>A separate study looking at different concentrations of Epithalon on early development found mature and aged adult flies to be the primary recipients of its effects. <a href=\"https:\/\/en.wikipedia.org\/wiki\/Genotoxicity\" rel=\"nofollow noopener\" target=\"_blank\"><strong>Genotoxicity<\/strong><\/a> was not observed.<\/p><h5><strong><b>3.Antitumor Potential<\/b><\/strong><\/h5><p>Epithalon reduces chromosomal instability; chromosomal deletions and various forms of mutation directly affect biological DNA. DNA deficiencies are typically the primary cause of cellular <a href=\"https:\/\/en.wikipedia.org\/wiki\/Carcinogenesis\" rel=\"nofollow noopener\" target=\"_blank\"><strong>carcinogenesis<\/strong><\/a>.<\/p><p>A long-term double-blind study demonstrated a direct reduction in both tumor incidence and diversity from Epithalon treatment. An active role in inhibiting more specific aspects of tumor development is also observed. Treating tumors of identical size and location, long-term therapy with Epithalon resulted in significantly smaller subsequent tumor growth.<\/p><h5><strong><b>4.Endocrine Regulatory Effects<\/b><\/strong><\/h5><p>Epithalon is a bioactive agent capable of significantly influencing the behavior of gastric endocrine cells.<\/p><p>An experiment using middle-aged rats saw the pineal gland removed from the subjects; the experimental group received continuous Epithalon administration. Counting of gastrin-producing and somatostatin-producing cells showed near perfect preservation of the desired <a href=\"https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/endocrine-cell\" rel=\"nofollow noopener\" target=\"_blank\"><strong>endocrine cell<\/strong><\/a> types compared to controls. Mitigating the near-complete loss of these cells following pineal removal is a clear indication of Epithalon&#8217;s effect on at least some form of gastric endocrine cell behavior.<\/p><h5><strong><b>5.Tissue Regeneration and Repair Function<\/b><\/strong><\/h5><p>Epithalon exhibits a certain similarity to <a href=\"https:\/\/en.wikipedia.org\/wiki\/Retinoid\" rel=\"nofollow noopener\" target=\"_blank\"><strong>retinoids<\/strong><\/a>. Examining retinal tissue morphology in middle aged mice, continuous Epithalon treatment preserved all retinal structures; complete retinal destruction was seen in untreated mice.<\/p><p>Retinal layers treated with Epithalon maintained their <a href=\"https:\/\/en.wikipedia.org\/wiki\/Integrity\" rel=\"nofollow noopener\" target=\"_blank\"><strong>integrity<\/strong><\/a>, with increases in what can only be described as &#8216;functional activity zones&#8217;. A clinical trial of patients (162 total, various ages) with retinitis pigmentosa is currently being followed; visual acuity improvements of 0.15-0.25 have been reported, along with all round visual field coverage (to some degree). Side effects have not been reported.<\/p><h5><strong><b>6.Improving Metabolic Function<\/b><\/strong><\/h5><p>In 2004, another experiment on macaque monkeys demonstrated Epithalon&#8217;s effect specifically on blood glucose levels. Young and aged monkeys received intramuscular injections of Epithalon; subsequent blood glucose measurements were taken.<\/p><p>Prior to administration, the aged monkeys showed significantly higher initial blood glucose levels. Post-dosing measurements revealed a clear and marked reduction in these levels for the older monkeys. Returning to baseline (at least temporarily) was observed one month after discontinuation of the administration.\u2076<\/p><h5><strong><b>7.Immune System Regulation<\/b><\/strong><\/h5><p>Studies using organotypic cultures of primary rat fibroblasts and various rat skin explants indicate some form of immune system regulatory function that Epithalon exhibits, at least within skin tissue.<\/p><p>Analysis of the treated cells showed increased (significantly so) <a href=\"https:\/\/en.wikipedia.org\/wiki\/SOD1\" rel=\"nofollow noopener\" target=\"_blank\"><strong>SOD-1<\/strong><\/a> and NQO1 expression &#8211; both being well documented antioxidant\/enzymatic markers. Promoting this type of &#8216;immune&#8217; or at least protective, regulatory function is something scientists have pointed to as a positive outcome.<\/p><h5><strong><b>8.Neuroprotection and Cognitive Enhancement<\/b><\/strong><\/h5><p>\u00a0Learning capacity was the focus of several studies; protection and repair of neurons (antioxidant effects being a large part of this process, along with more subtle neurotransmitter and near-term neurotrophic factor related improvements) are what Epithalon is capable of achieving.<\/p><p>Improved learning ability in aged monkeys is a direct result of all of the above mentioned factors.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-19731805204\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-19731805204\" data-tab-index=\"4\" style=\"--n-tabs-title-order: 4;\" class=\"elementor-element elementor-element-2236c6ad e-flex e-con-boxed e-con e-child\" 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class=\"\"><\/path><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tMS\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-19731805205\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-19731805205\" data-tab-index=\"5\" style=\"--n-tabs-title-order: 5;\" class=\"elementor-element elementor-element-3f32ae03 e-flex e-con-boxed e-con e-child\" data-id=\"3f32ae03\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-347543f9 e-con-full e-flex e-con e-child\" data-id=\"347543f9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2c5f13f9 elementor-widget elementor-widget-text-editor\" data-id=\"2c5f13f9\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12170316\/\" rel=\"nofollow noopener\" target=\"_blank\"><strong>(1) Khavinson, V. K.; Razumovskii, M. I.; Trofimova, S. V.; Grigor&#8217;yan, R. A.; Chaban, T. V.; Oleinik, T. L.; Razumovskaya, A. M. Effect of Epithalon on Age-Specific Changes in the Retina in Rats with Hereditary Pigmentary Dystrophy. <em>Bulletin of Experimental Biology and Medicine <\/em>2002, <em>133<\/em>\u00a0(1), 87-89. DOI: 10.1023\/a:1015125031829.<\/strong><\/a><\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10977918\/\" rel=\"nofollow noopener\" target=\"_blank\"><strong>(2) Khavinson, V. K.; Myl&#8217;nikov, S. V. Effect of pineal tetrapeptide on antioxidant defense inDrosophila melanogaster. <em>Bulletin of Experimental Biology and Medicine <\/em>2000, <em>129<\/em>\u00a0(4), 355-356. DOI: 10.1007\/bf02439268.<\/strong><\/a><\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12459848\/\" rel=\"nofollow noopener\" target=\"_blank\"><strong>(3) Anisimov, V. N.; Khavinson, V. K.; Alimova, I. N.; Semchenko, A. V.; Yashin, A. I. Epithalon Decelerates Aging and Suppresses Development of Breast Adenocarcinomas in Transgenic HER-2\/neu Mice. <em>Bulletin of Experimental Biology and Medicine <\/em>2002, <em>134<\/em>\u00a0(2), 187-190. DOI: 10.1023\/a:1021104819170.<\/strong><\/a><\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12360355\/\" rel=\"nofollow noopener\" target=\"_blank\"><strong>(4) Khavinson, V. K.; Malinin, V. V.; Timofeeva, N. M.; Egorova, V. V.; Nikitina, A. A. Effects of Epithalon on Activities Gastrointestinal Enzymes in Young and Old Rats. <em>Bulletin of Experimental Biology and Medicine <\/em>2002, <em>133<\/em>\u00a0(3), 290-292. DOI: 10.1023\/a:1015807305791.<\/strong><\/a><\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12910293\/\" rel=\"nofollow noopener\" target=\"_blank\"><strong>(5) Khavinson, V. K.; Razumovsky, M. I.; Trofimova, S. V.; Razumovskaya, A. M. Retinoprotective Effect of Epithalon in Campbell Rats of Various Ages. <em>Bulletin of Experimental Biology and Medicine <\/em>2003, <em>135<\/em>\u00a0(5), 495-498. DOI: 10.1023\/a:1024931812822.<\/strong><\/a><\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40141333\/\" rel=\"nofollow noopener\" target=\"_blank\"><strong>(6) Araj, S. K.; Brzezik, J.; M\u0105dra-Gackowska, K.; Szeleszczuk, \u0141. Overview of Epitalon\u2014Highly Bioactive Pineal Tetrapeptide with Promising Properties. <em>International Journal of Molecular Sciences <\/em>2025, <em>26<\/em>\u00a0(6). DOI: 10.3390\/ijms26062691.<\/strong><\/a><\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15664732\/\" rel=\"nofollow noopener\" target=\"_blank\"><strong>(7) Goncharova, N. D.; Vengerin, A. A.; Khavinson, V. K.; Lapin, B. A. Pineal peptides restore the age-related disturbances in hormonal functions of the pineal gland and the pancreas. <em>Experimental Gerontology <\/em>2005, <em>40<\/em>\u00a0(1-2), 51-57. 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