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545.344V320h64V256H510.208A286.336 286.336 0 0 1 448 404.992v140.352L378.176 654.72 405.12 640h58.432l43.456-68.032 4.992-17.28V320h128v234.688l4.992 17.28 43.456 68.032h58.432l26.944 14.72zM320 896H192v128H128v-128H0v-64h128v-128h64v128h128z\" fill=\"#86d2e9\" data-spm-anchor-id=\"a313x.search_index.0.i31.7a773a81Yn5fO8\" class=\"\"><\/path><path d=\"M256 128l-32 32L192 128V0h64zM88.256 43.008l-45.248 45.248 90.496 90.496h44.8v-45.504zM0 192v64h128l32-32L128 192z m43.008 167.744l45.248 45.248 90.496-90.496v-44.8h-45.504zM192 448h64V320l-32-32L192 320z m167.744-43.008l45.248-45.248-90.496-90.496h-44.8v45.504zM448 256V192H320l-32 32 32 32z m-43.008-167.744L359.744 43.008 269.248 133.504v44.8h45.504z\" fill=\"#515151\" data-spm-anchor-id=\"a313x.search_index.0.i33.7a773a81Yn5fO8\" class=\"selected\"><\/path><\/svg>\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" class=\"icon\" viewBox=\"0 0 1024 1024\" width=\"128\" height=\"128\"><path d=\"M752.64 864H399.36a65.92 65.92 0 0 1-15.36-2.112V768h-39.744c0.448-0.768 0.64-1.664 1.152-2.432L405.12 672h341.76l59.712 93.568a64 64 0 0 1-53.952 98.432z\" fill=\"#006758\" opacity=\".1\"><\/path><path d=\"M836.864 846.144a94.72 94.72 0 0 1-84.16 49.856H399.296A93.568 93.568 0 0 1 384 893.952v-66.112a29.952 29.952 0 0 0 15.296 4.16h353.408a32 32 0 0 0 26.944-49.28L729.6 704H422.4l-40.832 64h-72.32a96 96 0 0 1 9.152-19.648l59.712-93.632 27.008-14.72h341.76l27.008 14.72 59.712 93.568a94.976 94.976 0 0 1 3.264 97.856z\" fill=\"#86d2e9\" data-spm-anchor-id=\"a313x.search_index.0.i30.7a773a81Yn5fO8\" class=\"\"><\/path><path d=\"M672 554.688V288H504.832A285.312 285.312 0 0 1 480 356.032v198.4L425.536 640h300.8z\" fill=\"#515151\" opacity=\".1\" data-spm-anchor-id=\"a313x.search_index.0.i32.7a773a81Yn5fO8\" class=\"selected\"><\/path><path d=\"M704 545.344V320h64V256H510.208A286.336 286.336 0 0 1 448 404.992v140.352L378.176 654.72 405.12 640h58.432l43.456-68.032 4.992-17.28V320h128v234.688l4.992 17.28 43.456 68.032h58.432l26.944 14.72zM320 896H192v128H128v-128H0v-64h128v-128h64v128h128z\" fill=\"#86d2e9\" data-spm-anchor-id=\"a313x.search_index.0.i31.7a773a81Yn5fO8\" class=\"\"><\/path><path d=\"M256 128l-32 32L192 128V0h64zM88.256 43.008l-45.248 45.248 90.496 90.496h44.8v-45.504zM0 192v64h128l32-32L128 192z m43.008 167.744l45.248 45.248 90.496-90.496v-44.8h-45.504zM192 448h64V320l-32-32L192 320z m167.744-43.008l45.248-45.248-90.496-90.496h-44.8v45.504zM448 256V192H320l-32 32 32 32z m-43.008-167.744L359.744 43.008 269.248 133.504v44.8h45.504z\" fill=\"#515151\" data-spm-anchor-id=\"a313x.search_index.0.i33.7a773a81Yn5fO8\" class=\"selected\"><\/path><\/svg>\t\t<\/span>\n\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tliterature\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t\t<\/div>\n\t\t\t<div class=\"e-n-tabs-content\">\n\t\t\t\t<div id=\"e-n-tab-content-20871933201\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-20871933201\" data-tab-index=\"1\" style=\"--n-tabs-title-order: 1;\" class=\"e-active elementor-element elementor-element-5e04fb31 e-con-full e-flex e-con e-child\" data-id=\"5e04fb31\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-77f641b7 e-flex e-con-boxed e-con e-child\" data-id=\"77f641b7\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-768613d1 elementor-drop-cap-yes elementor-drop-cap-view-default elementor-widget elementor-widget-text-editor\" data-id=\"768613d1\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;drop_cap&quot;:&quot;yes&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>As a structural analog of <a href=\"https:\/\/en.wikipedia.org\/wiki\/%CE%91-Melanocyte-stimulating_hormone\"><strong>\u03b1-MSH (melanocyte-stimulating hormone)<\/strong><\/a>, Melanotan-II (MT-II) exhibits properties similar to \u03b1-MSH. It acts as a non-selective <a href=\"https:\/\/en.wikipedia.org\/wiki\/Melanocortin_receptor\"><strong>melanocortin receptor<\/strong><\/a> agonist, demonstrating activity at melanocortin receptors <a href=\"https:\/\/en.wikipedia.org\/wiki\/Melanocortin_1_receptor\"><strong>MC1R<\/strong><\/a>, <a href=\"https:\/\/en.wikipedia.org\/wiki\/Melanocortin_3_receptor\"><strong>MC3R<\/strong><\/a>, <a href=\"https:\/\/en.wikipedia.org\/wiki\/Melanocortin_4_receptor\"><strong>MC4R<\/strong><\/a> and <strong><a href=\"https:\/\/en.wikipedia.org\/wiki\/Melanocortin_5_receptor\">MC5R<\/a><\/strong>.<\/p><p>Structurally, Melanotan-II is a cyclic <a href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/heptapeptide\"><strong>heptapeptide<\/strong><\/a> (Ac-Nle-cyclo[Asp-His-DPhe-Arg-Trp-Lys]-NH\u2082). This cyclized architecture affords a shorter peptide chain than the linear MT-I.<\/p><p>Although in vitro studies indicate Melanotan-II exhibits weaker efficacy than Melanotan-I in activating <a href=\"https:\/\/en.wikipedia.org\/wiki\/Melanocyte\"><strong>melanocyte<\/strong><\/a> MC1R to induce pigmentation, Melanotan-II has been found to possess potential advantages in other aspects, particularly in central nervous system regulation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-20871933202\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-20871933202\" data-tab-index=\"2\" style=\"--n-tabs-title-order: 2;\" class=\" elementor-element elementor-element-3c3cd8b0 e-con-full e-flex e-con e-child\" data-id=\"3c3cd8b0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-4354620f e-flex e-con-boxed e-con e-child\" data-id=\"4354620f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5d1fa69e elementor-position-inline-start elementor-mobile-position-inline-start elementor-view-default elementor-widget elementor-widget-icon-box\" data-id=\"5d1fa69e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" class=\"icon\" viewBox=\"0 0 1024 1024\" data-spm-anchor-id=\"a313x.search_index.0.i80.7b0e3a8118k0Gw\" width=\"128\" height=\"128\"><path d=\"M128 489.792m25.610251-22.180384l-0.006047 0.005237q25.610251-22.180384 47.790635 3.429868l136.643735 157.773661q22.180384 25.610251-3.429867 47.790635l0.006047-0.005237q-25.610251 22.180384-47.790635-3.429868l-136.643735-157.773661q-22.180384-25.610251 3.429867-47.790635Z\" fill=\"#666666\"><\/path><path d=\"M624.140587 386.040089m-30.917398-13.855284l0.0073 0.003271q-30.917398-13.855284-44.772682 17.062114l-110.953507 247.5874q-13.855284 30.917398 17.062114 44.772682l-0.0073-0.003271q30.917398 13.855284 44.772682-17.062114l110.953507-247.5874q13.855284-30.917398-17.062114-44.772682Z\" fill=\"#666666\"><\/path><path d=\"M122.88 445.44m-107.52 0a107.52 107.52 0 1 0 215.04 0 107.52 107.52 0 1 0-215.04 0Z\" fill=\"#86d2e9\" data-spm-anchor-id=\"a313x.search_index.0.i79.7b0e3a8118k0Gw\" class=\"\"><\/path><path d=\"M634.88 286.72m-158.72 0a158.72 158.72 0 1 0 317.44 0 158.72 158.72 0 1 0-317.44 0Z\" fill=\"#86d2e9\" data-spm-anchor-id=\"a313x.search_index.0.i78.7b0e3a8118k0Gw\" class=\"\"><\/path><path d=\"M512 661.344A140.448 140.448 0 0 0 407.04 614.4c-77.76 0-140.8 63.04-140.8 140.8 0 77.76 63.04 140.8 140.8 140.8 41.704 0 79.176-18.136 104.96-46.952V661.344zM491.52 755.2c0 46.656-37.824 84.48-84.48 84.48-46.656 0-84.48-37.824-84.48-84.48 0-46.656 37.824-84.48 84.48-84.48 46.656 0 84.48 37.824 84.48 84.48z\" fill=\"#86d2e9\" data-spm-anchor-id=\"a313x.search_index.0.i76.7b0e3a8118k0Gw\" class=\"\"><\/path><path d=\"M701.44 339.616a33.872 33.872 0 0 0-3.424 47.784L805.928 512h86.392a33.816 33.816 0 0 0-6.44-11.176L749.232 343.048a33.872 33.872 0 0 0-47.784-3.432z\" fill=\"#666666\"><\/path><path d=\"M997.848 512h-183.216a107.448 107.448 0 0 1 91.608-51.2c38.728 0 72.68 20.48 91.608 51.2z\" fill=\"#86d2e9\" data-spm-anchor-id=\"a313x.search_index.0.i77.7b0e3a8118k0Gw\" class=\"\"><\/path><path d=\"M838.096 600h-76.192v161.904H600v76.192h161.904V1000h76.192v-161.904H1000v-76.192h-161.904V600z\" fill=\"#86d2e9\" data-spm-anchor-id=\"a313x.search_index.0.i75.7b0e3a8118k0Gw\" class=\"\"><\/path><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h5 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tSequence\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tAc-{Nle}-Asp-His-{d-Phe}-Arg-Trp-Lys-NH2, (2\u21927)-lactam\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-303d1a93 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"303d1a93\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6d07a38 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class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6af62d56 elementor-position-inline-start elementor-mobile-position-inline-start elementor-view-default elementor-widget elementor-widget-icon-box\" data-id=\"6af62d56\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" class=\"icon\" viewBox=\"0 0 1103 1024\" data-spm-anchor-id=\"a313x.search_index.0.i194.7b0e3a8118k0Gw\" width=\"137.875\" height=\"128\"><path d=\"M550.591841 40.959622a78.768504 78.768504 0 0 0-78.768504 78.768504 78.768504 78.768504 0 1 0 157.537007 0 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290.655779 290.655779 0 0 0 207.94885-132.331086l78.768504 49.624157a123.666551 123.666551 0 0 0 50.411842 148.084787 115.002015 115.002015 0 0 0 59.076378 15.753701 118.152756 118.152756 0 0 0 101.611369-60.651748 125.241921 125.241921 0 0 0 20.479811-92.159149z m-905.050107 51.987212a78.768504 78.768504 0 0 1-36.233512 48.836472 74.042393 74.042393 0 0 1-59.076377 7.876851A78.768504 78.768504 0 0 1 50.411842 945.222044a82.706929 82.706929 0 0 1-7.87685-61.439433 78.768504 78.768504 0 0 1 35.445827-51.987212 78.768504 78.768504 0 0 1 38.596566-11.027591 92.159149 92.159149 0 0 1 20.479811 0 78.768504 78.768504 0 0 1 47.261103 37.808882 87.433039 87.433039 0 0 1 8.664535 64.590173zM471.823337 122.091181a78.768504 78.768504 0 1 1 157.537007 0 78.768504 78.768504 0 1 1-157.537007 0z m78.768504 701.827367a181.955243 181.955243 0 0 1 0-363.910487 181.955243 181.955243 0 0 1 0 363.910487zM1052.347209 945.222044a78.768504 78.768504 0 0 1-106.33748 29.932032 78.768504 78.768504 0 0 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fill=\"#86d2e9\" data-spm-anchor-id=\"a313x.search_index.0.i195.7b0e3a8118k0Gw\" class=\"\"><\/path><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h5 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tMolecular Formula\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tC50H69N15O9\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2cb8ec46 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"2cb8ec46\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-73399b33 elementor-position-inline-start elementor-mobile-position-inline-start elementor-view-default elementor-widget elementor-widget-icon-box\" data-id=\"73399b33\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" class=\"icon\" viewBox=\"0 0 1242 1024\" width=\"155.25\" height=\"128\"><path d=\"M881.892257 790.935454l-89.133129-30.532837c0.094822-2.180917 0.189645-4.267011 0.189645-6.447929 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9.387426-70.737567-0.284467-121.562416-76.521739-230.039329-190.877647-271.38193v167.740962c75.383869 7.965088 132.561823 71.496148 132.561823 147.259307zM774.45839 820.61489v-2.65503c-35.273961 73.297775-123.174398 104.209902-196.566994 69.030764-31.196595-14.981951-56.134906-40.489198-70.453101-72.065083v2.65503l-183.291848 57.367598c92.167448 130.096438 272.424976 160.818921 402.616237 68.651473 38.687571-27.403696 70.073811-64.005172 91.314046-106.485641l-43.61834-16.499111zM763.74345 141.685954c1.327515-76.901029-59.927805-140.337266-136.828834-141.66478-76.901029-1.327515-140.337266 59.927805-141.66478 136.828834-1.13787 66.091266 44.376919 123.932977 108.951026 138.251172v144.604277c12.801034-2.465384 26.076181-1.422337 38.30828 3.129142 9.861538 1.327515 19.15414 5.499704 26.739939 12.042454V275.10118c60.970853-15.645709 103.925435-70.4531 104.494369-133.415226zM1062.813543 753.859866c-44.945854 0.189645-86.193632 25.222779-107.244222 64.953397l-106.770109-40.015086c5.215236 23.041862-3.034319 47.031949-21.335057 61.824255l114.355907 47.600884c6.637573 66.755024 66.091266 115.493777 132.846291 108.856203s115.493777-66.091266 108.856203-132.84629c-6.163461-62.203545-58.600291-109.614783-121.183125-109.425138l0.474112-0.948225zM310.776478 879.404826c-6.637573-19.15414-16.024999-37.834168-25.317602-59.169226l-55.660794 16.878401C193.670719 780.599805 118.571317 764.005871 62.057121 800.228057c-56.514196 36.127364-73.013307 111.226766-36.885944 167.740962 36.127364 56.514196 111.226766 73.013307 167.740962 36.885944 34.894672-22.283282 56.040084-60.87603 56.040084-102.408276v-6.258283l61.824255-16.783578z\" fill=\"#515151\" data-spm-anchor-id=\"a313x.search_index.0.i169.7b0e3a8118k0Gw\" class=\"selected\"><\/path><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h5 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tMolecular Weight\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\t1024.18\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-20871933203\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-20871933203\" data-tab-index=\"3\" style=\"--n-tabs-title-order: 3;\" class=\" elementor-element elementor-element-7339fb92 e-con-full e-flex e-con e-child\" data-id=\"7339fb92\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-5903caca e-flex e-con-boxed e-con e-child\" data-id=\"5903caca\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-619be827 elementor-widget elementor-widget-text-editor\" data-id=\"619be827\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4>Research Of Melanotan-II<\/h4><h5>1.what is melanotan-II<\/h5><h6>1)Discovery and Development<\/h6><p>Melanotan-II is a synthetic melanocortin receptor agonist initially developed for skin cancer protection. However, its unexpected discovery of central nervous system and sexual function regulatory effects has expanded its potential applications across multiple fields.<\/p><h6>2) Skin Pigmentation Effects<\/h6><p>As an analog of \u03b1-MSH, Melanotan-II can activate melanocytes and induce skin tanning. In a single-blind study, three participants received either saline or Melanotan-II via subcutaneous injection once daily on weekdays for two weeks.<\/p><p>Measurements were repeated at the same site on day 21. Visual assessment revealed noticeable facial pigmentation in participants following administration. Evidence indicates that Melanotan-II promotes tanning through its action as an agonist at the MC1R in melanocytes\u00b9.<\/p><h6>3)Erectile Dysfunction Treatment<\/h6><p>Melanotan-II can treat male erectile dysfunction (ED). In a small cohort of 10 patients with psychogenic ED, subcutaneous injection of the peptide (0.025 mg\/kg body weight) was evaluated via real-time monitoring within 6 hours: 8 men achieved clinically meaningful erections\u00b2.<\/p><p>These findings were later confirmed in a double-blind controlled study\u00b3.<\/p><h6>4)Metabolic Effects<\/h6><p>Animal studies have demonstrated that Melanotan-II suppresses appetite and promotes fat burning. Researchers specifically knocked out the <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9266911\/\"><strong>PTP1B(Protein Tyrosine Phosphatase 1B)<\/strong><\/a> gene (a negative regulator of leptin signaling) in <a href=\"https:\/\/en.wikipedia.org\/wiki\/Proopiomelanocortin\"><strong>POMC(Proopiomelanocortin<\/strong><\/a><a href=\"https:\/\/en.wikipedia.org\/wiki\/Proopiomelanocortin\"><strong>)<\/strong><\/a>\u00a0neurons of mice.<\/p><p>These mutant mice exhibited stronger responses to <a href=\"https:\/\/en.wikipedia.org\/wiki\/Intracerebroventricular_injection\"><strong>intracerebroventricular injections<\/strong><\/a> of <a href=\"https:\/\/en.wikipedia.org\/wiki\/Leptin\"><strong>leptin<\/strong><\/a> and Melanotan-II (a melanocortin receptor agonist), manifesting as enhanced appetite suppression, weight loss, and <a href=\"https:\/\/en.wikipedia.org\/wiki\/Thermogenics\"><strong>thermogenic<\/strong><\/a> responses.<\/p><p>Furthermore, this genetic deletion resulted in increased expression of the MC4R receptor in the mice\u2074.<\/p><h5>2.Conclusion<\/h5><p>Melanotan-II, as a non-selective melanocortin receptor agonist, not only shows promise for inducing skin pigmentation but has also garnered significant scientific interest for its potent centrally mediated effects on sexual function regulation, particularly in improving ED.<\/p><p>Its preliminary clinical results in ED treatment are encouraging, and its <a href=\"https:\/\/en.wikipedia.org\/wiki\/Pleiotropy\"><strong>pleiotropic<\/strong><\/a> mechanism of action establishes a promising foundation for the development of novel ED therapeutics.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-20871933204\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-20871933204\" data-tab-index=\"4\" style=\"--n-tabs-title-order: 4;\" class=\" elementor-element elementor-element-2d166d0c e-flex e-con-boxed e-con e-child\" 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id=\"e-n-tab-content-20871933205\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-20871933205\" data-tab-index=\"5\" style=\"--n-tabs-title-order: 5;\" class=\" elementor-element elementor-element-7af6999d e-flex e-con-boxed e-con e-child\" data-id=\"7af6999d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-16126d6d e-con-full e-flex e-con e-child\" data-id=\"16126d6d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7820889a elementor-widget elementor-widget-text-editor\" data-id=\"7820889a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8637402\/\"><strong>(1) Dorr, R. T.; Lines, R.; Levine, N.; Brooks, C.; Xiang, L.; Hruby, V. J.; Hadley, M. E. Evaluation of Melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study. <em>Life Sciences <\/em>1996, <em>58<\/em>\u00a0(20), 1777-1784. DOI: 10.1016\/0024-3205(96)00160-9.<\/strong><\/a><\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9679884\/\"><strong>(2) Wessells, H.; Fuciarelli, K.; Hansen, J.; Hadley, M. E.; Hruby, V. J.; Dorr, R.; Levine, N. Synthetic Melanotropic Peptide Initiates Erections in Men with Psychogenic Erectile Dysfunction: Double-Blind, Placebo Controlled Crossover Study. <em>Journal of Urology <\/em>1998, <em>160<\/em>\u00a0(2), 389-393. DOI: 10.1016\/s0022-5347(01)62903-3.<\/strong><\/a><\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11035391\/\"><strong>(3) Wessells, H.; Levine, N.; Hadley, M. E.; Dorr, R.; Hruby, V. Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II. <em>International Journal of Impotence Research <\/em>2000, <em>12<\/em>\u00a0(S4), S74-S79. DOI: 10.1038\/sj.ijir.3900582.<\/strong><\/a><\/p><p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3468506\/\"><strong>(4) De Jonghe, B. C.; Hayes, M. R.; Zimmer, D. J.; Kanoski, S. E.; Grill, H. J.; Bence, K. K. Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency. <em>American Journal of Physiology-Endocrinology and Metabolism <\/em>2012, <em>303<\/em>\u00a0(5), E644-E651. DOI: 10.1152\/ajpendo.00009.2012.<\/strong><\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7dfef73b elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"7dfef73b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b9e642c elementor-widget elementor-widget-image\" data-id=\"b9e642c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"160\" src=\"https:\/\/molchanges.com\/wp-content\/uploads\/2025\/08\/ArticleLiterature-Citation-Notes_-1024x160.jpg\" class=\"attachment-large size-large wp-image-9142 wp-post-image\" alt=\"\" srcset=\"https:\/\/molchanges.com\/wp-content\/uploads\/2025\/08\/ArticleLiterature-Citation-Notes_-1024x160.jpg 1024w, https:\/\/molchanges.com\/wp-content\/uploads\/2025\/08\/ArticleLiterature-Citation-Notes_-300x47.jpg 300w, https:\/\/molchanges.com\/wp-content\/uploads\/2025\/08\/ArticleLiterature-Citation-Notes_-768x120.jpg 768w, https:\/\/molchanges.com\/wp-content\/uploads\/2025\/08\/ArticleLiterature-Citation-Notes_-1536x240.jpg 1536w, https:\/\/molchanges.com\/wp-content\/uploads\/2025\/08\/ArticleLiterature-Citation-Notes_-18x3.jpg 18w, https:\/\/molchanges.com\/wp-content\/uploads\/2025\/08\/ArticleLiterature-Citation-Notes_-600x94.jpg 600w, https:\/\/molchanges.com\/wp-content\/uploads\/2025\/08\/ArticleLiterature-Citation-Notes_.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t<div class=\"elementor-element elementor-element-130732a e-flex e-con-boxed e-con e-parent\" data-id=\"130732a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-beacfb2 elementor-widget elementor-widget-image\" data-id=\"beacfb2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1024\" height=\"320\" src=\"https:\/\/molchanges.com\/wp-content\/uploads\/2025\/08\/\u6dfb\u52a0\u6807\u9898-1024x320.jpg\" class=\"attachment-large size-large wp-image-9143 wp-post-image\" alt=\"\" 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