{"id":9822,"date":"2025-11-17T16:09:42","date_gmt":"2025-11-17T08:09:42","guid":{"rendered":"https:\/\/molchanges.com\/?post_type=product&#038;p=9822"},"modified":"2025-12-31T01:38:04","modified_gmt":"2025-12-30T17:38:04","slug":"palmitoyl-tetrapeptide-7","status":"publish","type":"product","link":"https:\/\/molchanges.com\/zh\/palmitoyl-tetrapeptide-7","title":{"rendered":"Palmitoyl Tetrapeptide-7"},"content":{"rendered":"<div data-elementor-type=\"product-post\" data-elementor-id=\"9822\" class=\"elementor elementor-9822\" data-elementor-post-type=\"product\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-358a5cb9 ct-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"358a5cb9\" data-element_type=\"section\" data-e-type=\"section\" 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class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Palmitoyl tetrapeptide-7 (Rigin\u2122) is a synthetic tetrapeptide. The sequence of this peptide originates from a fragment of the heavy chain of <a href=\"https:\/\/www.sciencedirect.com\/topics\/biochemistry-genetics-and-molecular-biology\/immunoglobulin-g\" rel=\"nofollow noopener\" target=\"_blank\"><strong>Immunoglobulin G (IgG)<\/strong><\/a>, a key protein the human body produces. Linked at its N-terminus to palmitic acid through an amide bond, it transitions from being largely water soluble to a form with inherent lipophilicity. Enhanced penetration of the skin&#8217;s stratum corneum barrier is possible, reaching various points within the dermis.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-3066031822\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-3066031822\" data-tab-index=\"2\" style=\"--n-tabs-title-order: 2;\" class=\"elementor-element elementor-element-59c8a207 e-con-full e-flex e-con e-child\" data-id=\"59c8a207\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-5bf39b79 e-flex e-con-boxed e-con e-child\" data-id=\"5bf39b79\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-700235ca elementor-position-inline-start elementor-mobile-position-inline-start elementor-view-default elementor-widget elementor-widget-icon-box\" data-id=\"700235ca\" 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class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tPal-Gly-Gln-Pro-Arg-OH\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a39cef elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"a39cef\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4f86c4c7 elementor-position-inline-start elementor-mobile-position-inline-start elementor-view-default elementor-widget elementor-widget-icon-box\" data-id=\"4f86c4c7\" data-element_type=\"widget\" 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0-252.846897-265.449857 9.45222 9.45222 0 0 0-10.239905 9.45222z\" fill=\"#86d2e9\" data-spm-anchor-id=\"a313x.search_index.0.i195.7b0e3a8118k0Gw\" class=\"\"><\/path><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h5 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\t\u5206\u5b50\u5f0f\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tC34H62N8O7\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1183f653 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"1183f653\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-39644c40 elementor-position-inline-start elementor-mobile-position-inline-start elementor-view-default elementor-widget elementor-widget-icon-box\" data-id=\"39644c40\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" class=\"icon\" viewbox=\"0 0 1242 1024\" width=\"155.25\" height=\"128\"><path 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9.19778-46.842304 9.387426-70.737567-0.284467-121.562416-76.521739-230.039329-190.877647-271.38193v167.740962c75.383869 7.965088 132.561823 71.496148 132.561823 147.259307zM774.45839 820.61489v-2.65503c-35.273961 73.297775-123.174398 104.209902-196.566994 69.030764-31.196595-14.981951-56.134906-40.489198-70.453101-72.065083v2.65503l-183.291848 57.367598c92.167448 130.096438 272.424976 160.818921 402.616237 68.651473 38.687571-27.403696 70.073811-64.005172 91.314046-106.485641l-43.61834-16.499111zM763.74345 141.685954c1.327515-76.901029-59.927805-140.337266-136.828834-141.66478-76.901029-1.327515-140.337266 59.927805-141.66478 136.828834-1.13787 66.091266 44.376919 123.932977 108.951026 138.251172v144.604277c12.801034-2.465384 26.076181-1.422337 38.30828 3.129142 9.861538 1.327515 19.15414 5.499704 26.739939 12.042454V275.10118c60.970853-15.645709 103.925435-70.4531 104.494369-133.415226zM1062.813543 753.859866c-44.945854 0.189645-86.193632 25.222779-107.244222 64.953397l-106.770109-40.015086c5.215236 23.041862-3.034319 47.031949-21.335057 61.824255l114.355907 47.600884c6.637573 66.755024 66.091266 115.493777 132.846291 108.856203s115.493777-66.091266 108.856203-132.84629c-6.163461-62.203545-58.600291-109.614783-121.183125-109.425138l0.474112-0.948225zM310.776478 879.404826c-6.637573-19.15414-16.024999-37.834168-25.317602-59.169226l-55.660794 16.878401C193.670719 780.599805 118.571317 764.005871 62.057121 800.228057c-56.514196 36.127364-73.013307 111.226766-36.885944 167.740962 36.127364 56.514196 111.226766 73.013307 167.740962 36.885944 34.894672-22.283282 56.040084-60.87603 56.040084-102.408276v-6.258283l61.824255-16.783578z\" fill=\"#515151\" data-spm-anchor-id=\"a313x.search_index.0.i169.7b0e3a8118k0Gw\" class=\"selected\"><\/path><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h5 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\t\u5206\u5b50\u91cf\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\t694.91 g\/mol\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-3066031823\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-3066031823\" data-tab-index=\"3\" style=\"--n-tabs-title-order: 3;\" class=\"elementor-element elementor-element-5c3ee87e e-con-full e-flex e-con e-child\" data-id=\"5c3ee87e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-7fb0ef27 e-flex e-con-boxed e-con e-child\" data-id=\"7fb0ef27\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-342d890b elementor-widget elementor-widget-text-editor\" data-id=\"342d890b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4>Research Of Palmitoyl Tetrapeptide-7<\/h4><p>Palmitoyl Tetrapeptide-7 draws direct inspiration from endogenous <a href=\"https:\/\/en.wikipedia.org\/wiki\/Biomolecule\" rel=\"nofollow noopener\" target=\"_blank\"><strong>biomolecules<\/strong><\/a>; the core tetrapeptide itself (Gly-Gln-Pro-Arg) corresponds to specific amino acids (341-344 if remembered correctly) on IgG. IgG itself is one of the more important antibodies, central to many forms of immune regulation.<\/p><p>Mimicking this fragment confers the unique biological activity associated with Palmitoyl Tetrapeptide-7 &#8211; immune modulation being the prime example, anti-inflammatory functions.<\/p><p>Acting as a signaling peptide, direct structural &#8216;supplementation&#8217; of the skin is not its primary function; binding to certain cell surface receptors and the subsequent transmission of at least partially defined biological signals is what it achieves.<\/p><p>Cellular repair and regenerative type behavior follows from these signals.<\/p><p>Reduction of basal interleukin-6 secretion, post UVB induced inflammation being one of the more measurable effects, is well documented.<\/p><p>Laminin and various collagens (VII if I recall correctly) are all positively influenced by treatment.<\/p><p>Glycation damage (to some extent) is also lessened by the anti-inflammatory actions of the peptide.<\/p><p>In vivo reflectance confocal microscopy studies showed a clear enhancement of the extracellular matrix structure in treated subjects.<\/p><p>Over 60 volunteers, treated with a topical formulation containing Palmitoyl Tetrapeptide-7, showed a significant and quantifiable improvement in photoaged skin, with all or part of the above mentioned benefits being the end result of improved skin appearance.<\/p><p>In commercial applications, Palmitoyl Tetrapeptide-7 is often combined with <a href=\"https:\/\/molchanges.com\/zh\/palmitoyl-tripeptide-1\/\"><strong>Palmitoyl Tripeptide-1<\/strong><\/a> to form the well-known ingredient complex Matrixyl 3000.<\/p><p>These two peptides work synergistically; Palmitoyl Tripeptide-1 primarily promoting collagen synthesis, and Palmitoyl Tetrapeptide-7 taking on the important anti-inflammatory role.<\/p><p>A more comprehensive approach to combating various aspects of skin aging is achieved through this combination.<\/p><p>Palmitoyl Tetrapeptide-7 itself is a highly effective signaling peptide, biomimetically designed.<\/p><p>Its unique dual-action mechanism &#8211; inhibiting the key inflammatory factor IL-6 (by mimicking small fragments of immunoglobulin IgG), delivering both anti-inflammatory and anti-glycation effects; simultaneously serving as a true signaling molecule to at least partially regenerate dermal fibroblasts (collagen, elastin, hyaluronic acid being the end products) &#8211; is what gives it such widespread and specific application value.<\/p><p>Anti-aging and repair oriented products will always have a place for this peptide.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-3066031824\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-3066031824\" data-tab-index=\"4\" style=\"--n-tabs-title-order: 4;\" class=\"elementor-element elementor-element-11a566 e-flex e-con-boxed e-con e-child\" data-id=\"11a566\" 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class=\"\"><\/path><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tMS\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-3066031825\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-3066031825\" data-tab-index=\"5\" style=\"--n-tabs-title-order: 5;\" class=\"elementor-element elementor-element-38d132df e-flex e-con-boxed e-con e-child\" data-id=\"38d132df\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-46626dc4 e-con-full e-flex e-con e-child\" data-id=\"46626dc4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b7e826a elementor-widget elementor-widget-text-editor\" data-id=\"b7e826a\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;ekit_we_effect_on&quot;:&quot;none&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25817264\/\" rel=\"nofollow noopener\" target=\"_blank\"><strong>(1) Mondon, P.; Hillion, M.; Peschard, O.; Andre, N.; Marchand, T.; Doridot, E.; Feuilloley, M. G. J.; Pionneau, C.; Chardonnet, S. Evaluation of dermal extracellular matrix and epidermal\u2013dermal junction modifications using matrix\u2010assisted laser desorption\/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications. <em>Journal of Cosmetic Dermatology <\/em>2015, <em>14<\/em>\u00a0(2), 152-160. DOI: 10.1111\/jocd.12135.<\/strong><\/a><\/p><p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2774146\/\" rel=\"nofollow noopener\" target=\"_blank\"><strong>(2) Watson, R. E. B.; Ogden, S.; Cotterell, L. F.; Bowden, J. J.; Bastrilles, J. Y.; Long, S. P.; Griffiths, C. E. M. A cosmetic \u2018anti-ageing\u2019 product improves photoaged skin: a double-blind, randomized controlled trial. <em>British Journal of Dermatology <\/em>2009, <em>161<\/em>\u00a0(2), 419-426. DOI: 10.1111\/j.1365-2133.2009.09216.x.<\/strong><\/a><\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11348454\/\" rel=\"nofollow noopener\" target=\"_blank\"><strong>(3) Watson, R. E. B.; Craven, N. M.; Griffiths, C. E. M.; Kang, S.; Jones, C. J. P.; Kielty, C. M. A Short-Term Screening Protocol, Using Fibrillin-1 as a Reporter Molecule, for Photoaging Repair Agents. <em>Journal of Investigative Dermatology <\/em>2001, <em>116<\/em>\u00a0(5), 672-678. 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