Epithalon ne mai bioactive tetrapeptide gano kuma an inganta su ta hanyar nazarin aiki na pineal gland shine yake. takamaiman jerin amino acid shine Ala-Glu-Asp-Gly.
A lokacin 1980s, Masana kimiyya na Rasha sun gudanar da bincike mai zurfi a cikin tsarin aikin glandan pineal a cikin matakai daban-daban na tsufa.. Bioactive ƙananan ƙwayoyin cuta peptide gutsuttsura an ware kuma an kwatanta su a matsayin wani ɓangare na wannan aikin;
Epithalon da kansa ya samo asali ne daga irin wannan guntu mai aiki. Haɓaka wannan peptide ya haifar da nasarar haɗin gwiwar sa na wucin gadi.
Kasance cikin mafi ƙayyadaddun nau'in peptides na bioregulatory, Epithalon musamman gane wasu siffofin maganganun kwayoyin halitta kuma daga baya ayyukan salula.
M a cikin vivo da nau'ikan gwaje-gwajen in vitro daban-daban sun nuna cewa yana kunna magana ta musamman telomerase reverse transcriptase (TERT) – Subunit na telomerase – wanda shi ne kusa da duniya core inji na tsufa na salula.
Telomerase hadawa (kuma zuwa babban adadin ramawa) asarar tsayin telomere a chromosome ƙare; maimaita rabon tantanin halitta yana haifar da wannan asara. Tsawaita tsayin telomere kai tsaye yana inganta iyakan kwafin in vitro na sel, rage gudu duk ‘alamu’ na gaskiya salon tsufa tsufa.
Samfuran dabba sun nuna tasiri mai mahimmanci daga Epithalon: haɓaka tsawon rayuwar halittu, aƙalla juye juye juye na raguwar ilimin lissafi da ke da alaƙa da shekaru, tsarin tsarin rigakafi, hanawa (wasu) Turigenesis, da kuma zuwa wani batu na endocrin ma'auni maidowa.
Gyara mahimmin maganganun kwayoyin halitta da mallaka (zuwa wani mataki) An yi imanin kaddarorin antioxidant sune abubuwan da ke haifar da duk abubuwan da ke sama. Epithalon, saboda, ya kasance wani fili mai kima mai kima sosai a duk layin bincike na rigakafin tsufa.
Jeri
H-Ala-Glu-Asp-Gly-OH
Lambar CAS
307297-39-8
Tsarin kwayoyin halitta
Saukewa: C14H22N4O9
Nauyin Kwayoyin Halitta
390.35
Binciken Epithalon
1.Tasirin hana tsufa
Telomeres su ne na musamman na DNA-protein complexes waɗanda suke a ƙarshen eukaryotic chromosomes. Babban aikin su shine kare ƙarshen chromosome daga saninsa azaman lalacewar DNA; hana kowane nau'i na lalata chromosomal yana da matukar muhimmanci. Kowace rabon tantanin halitta yana haifar da ɗan guntuwar waɗannan telomeres.
Samun ɗan ɗan gajeren tsayi yana haifar da maimaitawa hankali ko hanyoyin amsa lalacewar DNA daban-daban; kama rabon tantanin halitta (musamman a cikin Farashin G1) da kuma ɓoyayyun kwayoyin halitta da yawa masu alaƙa da tsufa na salula shine sakamakon ƙarshe.
Telomerase, a ribonucleoprotein juyar da rubutu, yana haɓaka haɗin wannan telomere DNA kuma yana ƙara shi zuwa ƙarshen chromosome – ramawa ga ragewar baya. Epithalon musamman yana kunna kwayar halittar TERT da ke da alhakin wannan aikin, Ainihin daidaita telomerase.
Nazarin samfurin dabba sun nuna alluran lokaci-lokaci don tsawaita tsawon rayuwa sosai, jinkirta sassa da yawa na raguwar ilimin lissafi masu alaƙa da shekaru, rage (kusa cikakke kawarwa) daban-daban pathologies na tsufa, da kuma kewaye da daidaita maɓalli na hanyoyin jin daɗi.
2.Antioxidant da anti-mai kumburi sakamako
Drosophila melanogaster shine ingantaccen tsari don kimantawa lipid peroxidation matakan. A lokacin tsutsa matakin ƙari na 0.00001% Epithalon ya yi nasarar hana haɓakar da ake tsammani a cikin peroxidation. Ana nuna tasirin maganin antioxidant mai ƙarfi da kuma babban tasirin anti-mai kumburi ta wannan sakamakon.
Wani bincike na daban wanda ke duba nau'ikan nau'ikan Epithalon a farkon haɓakawa ya gano balagagge da tsofaffi sun tashi don zama farkon masu karɓar tasirin sa.. Genotoxicity ba a lura ba.
3.Yiwuwar Antitumor
Epithalon yana rage rashin zaman lafiyar chromosomal; gogewar chromosomal da nau'ikan maye gurbi daban-daban suna shafar DNA na halitta kai tsaye. Rashin DNA yawanci shine farkon dalilin salula ciwon daji.
Wani bincike na makafi na dogon lokaci ya nuna raguwa kai tsaye a cikin cututtukan tumo da kuma bambancin maganin Epithalon.. Hakanan ana lura da rawar aiki mai ƙarfi don hana ƙarin takamaiman abubuwan ci gaban ƙari. Maganin ciwace-ciwacen girma iri ɗaya da wuri, Jiyya na dogon lokaci tare da Epithalon ya haifar da ƙarami kaɗan girma girma na ƙari.
4.Effects na Endocrine Regulatory
Epithalon wakili ne na bioactive wanda ke iya tasiri sosai ga halayen ƙwayoyin endocrine na ciki.
Wani gwaji da aka yi amfani da berayen masu matsakaicin shekaru ya ga an cire glandan pineal daga abubuwan; ƙungiyar gwaji ta sami ci gaba da gudanar da Epithalon. Ƙididdigar ƙwayoyin gastrin da ke samar da somatostatin sun nuna kusa da cikakken adana abin da ake so. endocrine cell iri idan aka kwatanta da sarrafawa. Rage kusan cikar asarar waɗannan sel bayan cirewar pineal alama ce ta bayyana tasirin Epithalon akan aƙalla wani nau'i na halayen ƙwayoyin cuta na ciki..
5.Farfadowar Nama da Ayyukan Gyara
Epithalon yana nuna wani kamanceceniya da retinoids. Yin nazarin ilimin halittar mahaifa a cikin mice masu matsakaicin shekaru, Ci gaba da jiyya na Epithalon ya kiyaye dukkan sifofin ido; An ga cikakkiyar lalatawar ido a cikin berayen da ba a kula da su ba.
Yadudduka na gani da aka yi da Epithalon sun kiyaye su mutunci, tare da karuwa a cikin abin da kawai za a iya kwatanta shi a matsayin 'yankunan ayyukan aiki'. Gwajin asibiti na marasa lafiya (162 duka, shekaru daban-daban) Tare da retinitis pigmentosa a halin yanzu ana bi; gani acuity kyautata na 0.15-0.25 an ruwaito, tare da duk kewayen filin gani da ido (zuwa wani mataki). Ba a ba da rahoton illar illa ba.
6.Inganta Ayyukan Metabolic
A ciki 2004, Wani gwaji akan birai macaque ya nuna tasirin Epithalon musamman akan matakan glucose na jini. Birai matasa da tsofaffi sun sami alluran Epithalon na ciki; an dauki matakan glucose na jini na gaba.
Kafin gudanarwa, birai da suka tsufa sun nuna mahimmancin matakan glucose na farko na jini. Ma'auni na bayan yin allurai ya bayyana raguwa da alamar raguwa a cikin waɗannan matakan ga tsofaffin birai. Komawa zuwa asali (aƙalla na ɗan lokaci) an kiyaye wata daya bayan dakatar da aikin.⁶
7.Ka'idar Tsarin rigakafi
Nazarin ta yin amfani da al'adun organotypic na fibroblasts na bera na farko da nau'ikan fata na bera suna nuna wani nau'i na tsarin tsarin rigakafi wanda Epithalon ke nunawa., aƙalla cikin ƙwayar fata.
Binciken sel da aka jiyya ya nuna ya karu (muhimmanci haka) SOD-1 da NQO1 magana – Dukansu suna da kyau rubuce-rubucen antioxidant / enzymatic alamomi. Inganta irin wannan nau'in '' rigakafi’ ko a kalla karewa, Ayyukan tsari wani abu ne da masana kimiyya suka nuna a matsayin sakamako mai kyau.
8.Kariyar Neuro da Haɓaka Haɓakawa
Ƙarfin ilmantarwa shine mayar da hankali na bincike da yawa; kariya da gyaran jijiyoyi (tasirin antioxidant kasancewa babban ɓangare na wannan tsari, tare da ƙarin dabarar neurotransmitter da abubuwan haɓaka abubuwan da ke da alaƙa na kusa) sune abin da Epithalon ke iya cimmawa.
Ingantacciyar ikon ilmantarwa a cikin tsofaffin birai sakamako ne kai tsaye na dukkan abubuwan da aka ambata a sama.
COA
HPLC
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