Epithalon bụ ihe na-arụ ọrụ ndụ tetrapeptide chọpụta ma nụchaa site na nyocha ọrụ nke pineal gland. Usoro amino acid kpọmkwem bụ Ala-Glu-Asp-Gly.
N'ime 1980s, Ndị ọkà mmụta sayensị Russia mere nyocha nke ọma na ọrụ nchịkwa nke pineal gland n'ime usoro ịka nká dị iche iche.. Bioactive obere-molekul A na-ekewa iberibe peptide dịpụrụ adịpụ ma mara dịka akụkụ nke ọrụ a;
Epithalon n'onwe ya sitere n'otu iberibe na-arụsi ọrụ ike. Nkwalite nke peptide a mere ka njikọ aka ya na-aga nke ọma.
Iso na ụdị nkọwapụta nke peptides bioregulatory, Epithalon na-amata kpọmkwem ụdị ụfọdụ okwu mkpụrụ ndụ ihe nketa na sochiri ya ọrụ cellular.
Nnukwu na vivo na ụdị dị iche iche nke in vitro nnwale egosila na ọ pụrụ iche na-eme ka okwu nke telomerase reverse transcriptase (TERT) – Akụkụ catalytic nke telomerase – nke bụ nso eluigwe na ala isi usoro nke ịka nká cellular.
Telomerase synthesizes (na ruo n'ókè dị ukwuu na-akwụ ụgwọ maka) ọnwụ nke telomere ogologo na chromosome na-agwụ; ugboro ugboro nkewa cell na-akpata ọnwụ a. Ịgbatị ogologo telomere na-eme ka njedebe in vitro megharịa mkpụrụ ndụ ozugbo, na-ebelata akara 'ihe niile metụtara’ nke ezi ịka nká cellular.
Ụdị anụmanụ egosipụtala mmetụta dị ukwuu sitere na Epithalon: ndu ogologo ndụ ndọtị, opekata mpe mweghachi nke mbelata physiological metụtara afọ, usoro mgbochi ọrịa, mgbochi nke (ụfọdụ) tumorigenesis, na n'ókè nke endocrine itule mweghachi.
Na-agbanwe mkpụrụ okwu mkpụrụ ndụ isi na inwe (ruo n'ókè ụfọdụ) Ekwenyere na akụrụngwa antioxidant bụ ihe na-akpata ihe niile dị n'elu. Epithalon, n'ihi ya, na-anọgide na-abụ ihe a na-akwanyere ùgwù nke ukwuu n'ahịrị nyocha nke mgbochi ịka nká.
Usoro
H-Ala-Glu-Asp-Gly-OH
Nọmba CAS
307297-39-8
Usoro ihe omimi
C14H22N4O9
Ibu molekụla
390.35
Nnyocha nke Epithalon
1.Mmetụta mgbochi ịka nká
Telomeres bụ ogige DNA-protein pụrụ iche dị na nsọtụ nke eukaryotic chromosomes. Ọrụ ha bụ isi bụ ichebe njedebe chromosome ka a mata ya dị ka mmebi DNA; igbochi ụdị ọ bụla nke mmebi chromosomal dị oke mkpa. Nkewa sel ọ bụla na-ebute mbelata nke telomeres ndị a.
Ịru obere ogologo na-akpalite mmegharị senescence ma ọ bụ usoro nzaghachi mmebi DNA dị iche iche; njide nke cell nkewa (kpọmkwem na Akụkụ G1) na nzuzo na-esote nke ọtụtụ homonụ metụtara ịka nká cellular bụ nsonaazụ njedebe.
Telomerase, a ribonucleoprotein tụgharịa transcriptase, na-akwalite njikọ nke telomere DNA a ma tinyeghachi ya na njedebe nke chromosome – na-akwụ ụgwọ maka mkpirisi gara aga. Epithalon na-arụ ọrụ kpọmkwem TERT gene maka ọrụ a, na-achịkwa telomerase nke ọma.
Ọmụmụ ụdị anụmanụ egosila ịgbatị oge ụfọdụ iji gbatịa ogologo ndụ, na-egbu oge ọtụtụ akụkụ nke ọdịda physiological metụtara afọ, belata (nso zuru ezu mkpochapu) pathologies dị iche iche nke ịka nká, na n'akụkụ niile na-emegharị isi ụzọ senescence ụzọ.
2.Antioxidant na mgbochi mkpali mmetụta
Drosophila melanogaster bụ ezigbo ihe nlereanya maka nyocha peroxidation lipid ọkwa. N'oge ahihia ogbo ihe mgbakwunye nke 0.00001% Epithalon nke ọma gbochiri mmụba a tụrụ anya na peroxidation kwuru. A na-egosipụta mmetụta antioxidant dị ike yana ruo n'ókè dị ukwuu nke mgbochi mkpali site na nsonaazụ a.
Ọmụmụ ihe dị iche na-eleba anya na ọkwa dị iche iche nke Epithalon na mmalite mmalite chọpụtara na ndị toro eto na ndị agadi na-efe efe ka ọ bụrụ ndị mbụ na-enweta mmetụta ya.. Genotoxicity ahụghị.
3.Enwere ike ime mgbochi
Epithalon na-ebelata ndakpọ chromosomal; mkpochapụ chromosomal na ụdị mmụgharị dị iche iche na-emetụta DNA nke ndụ. Enweghị ụkọ DNA na-abụkarị ihe na-akpata cellular carcinogenesis.
Nnyocha e mere ogologo oge nke kpuru ìsì abụọ gosipụtara mbelata kpọmkwem na ma ọrịa tumor na ụdị dị iche iche sitere na ọgwụgwọ Epithalon.. A na-ahụkwa ọrụ na-arụsi ọrụ ike n'igbochi akụkụ ụfọdụ nke mmepe etuto ahụ. Ịgwọ etuto ahụ nke nha na ọnọdụ ha, ọgwụgwọ ogologo oge na Epithalon mere ka uto tumor dị ntakịrị ntakịrị.
4.Mmetụta nchịkwa nke Endocrine
Epithalon bụ ihe na-arụ ọrụ bioactive nke nwere ike imetụta omume nke mkpụrụ ndụ endocrine.
Nnwale a na-eji oke oke mere agadi hụrụ ka ewepụrụ gland pineal n'ihe ndị ahụ; otu nnwale ahụ nwetara nchịkwa Epithalon na-aga n'ihu. Ọnụ ọgụgụ nke mkpụrụ ndụ na-emepụta gastrin na nke na-emepụta somatostatin gosipụtara na nso nso a na-echekwa ihe a chọrọ. endocrine cell ụdị tụnyere njikwa. Mbelata mfu nke mkpụrụ ndụ ndị a dị nso na-esochi mwepụ nke pineal bụ ihe ngosipụta doro anya nke mmetụta Epithalon na opekata mpe ụdị ụfọdụ omume sel endocrine gastric..
5.Nrụgharị anụ ahụ na arụ ọrụ mmezi
Epithalon na-egosipụta ụfọdụ myirịta retinoids. Na-enyocha ọdịdị anụ ahụ retina n'ime ụmụ oke ndị agadi, Ọgwụgwọ Epithalon na-aga n'ihu na-echekwa akụkụ retinal niile; A hụrụ mbibi retinal zuru oke n'ime ụmụ oke a na-agwọbeghị.
N'ígwé nke retina e ji Epithalon agwọ ya na-edobe ha iguzosi ike n'ezi ihe, na mmụba na ihe enwere ike ịkọwa dị ka 'mpaghara ọrụ ọrụ'. Nnwale ụlọ ọgwụ nke ndị ọrịa (162 ngụkọta, afọ dị iche iche) A na-eji retinitis pigmentosa mee ihe ugbu a; visual acuity ndozi nke 0.15-0.25 a kọwo, tinyere ihe niile gburugburu visual ubi mkpuchi (ruo n'ókè ụfọdụ). Akọpụtabeghị mmetụta ndị ọ na-akpata.
6.Na-emeziwanye Ọrụ Metabolic
N'ime 2004, Nnwale ọzọ na enwe macaque gosipụtara mmetụta Epithalon kpọmkwem na ọkwa glucose ọbara. Enwe na-eto eto na ndị agadi nwetara ntụtụ intramuscular nke Epithalon; A na-enyocha glucose ọbara n'afọ ọzọ.
Tupu nchịkwa, enwe ndị merela agadi gosipụtara ọkwa glucose mbụ dị elu karịa. Ntụle mgbe emechara ọgwụ ahụ gosipụtara mbelata nke ọma na akara nke ọkwa ndị a maka enwe ndị meworo agadi. Na-alaghachi na ntọala (opekata mpe nwa oge) a hụrụ otu ọnwa ka a kwụsịrị nchịkwa ahụ.⁶
7.Usoro iwu mgbochi ọrịa
Nnyocha na-eji omenala organotypic nke isi fibroblasts oke oke na ụdị akpụkpọ anụ dị iche iche na-egosi ụfọdụ ụdị ọrụ nhazi usoro ahụ ji alụso ọrịa ọgụ na Epithalon gosipụtara., ọ dịkarịa ala n'ime anụ ahụ anụ ahụ.
Nyocha nke mkpụrụ ndụ ndị a na-emeso gosipụtara mmụba (nke ukwuu otú ahụ) SOD-1 na okwu NQO1 – Ha abụọ na-edepụta nke ọma ihe nrịbama antioxidant/enzymatic. Na-akwalite ụdị 'immune' a’ ma ọ bụ ọ dịkarịa ala nchebe, ọrụ nchịkwa bụ ihe ndị ọkà mmụta sayensị rụtụrụ aka dị ka ihe dị mma.
8.Neuroprotection na nkwalite ọgụgụ isi
Ikike mmụta bụ isi n'ọtụtụ ọmụmụ ihe; nchebe na mmezi nke neurons (mmetụta antioxidant bụ akụkụ buru ibu nke usoro a, yana nrụnye ihe na-adịghị ahụkebe na nhụsianya metụtara ihe neurotrophic dị nso) bụ ihe Epithalon nwere ike imezu.
Ikike mmụta ka mma na enwe agadi bụ nsonaazụ nke ihe niile a kpọtụrụ aha n'elu.
COA
HPLC
MS
