Hexapeptide-33 (raupapa: Ser-Phe-Lys-Leu-Arg-Tyr-NH₂, SFKLRY; W3 peptide) is a hexa-amino acid peptide.
First created by Novacell Technology through peptide library technology, This was made for cosmetic use and has several skincare benefits: the ability to induce angiogenesis; enhance skin elasticity; whakaiti i nga kita; and improve barrier function.
This peptide exerts its effects through binding to G-protein coupled receptors (GPCRs) widely expressed in human cells, particularly in skin keratinocytes where it participates in epidermal differentiation processes.
It is precisely because of the safety and efficacy of Hexapeptide-33, it has become a hot ingredient in many top anti-aging/brightening/repairing skin care products.
Raupapa
Ser-Phe-Lys-Leu-Arg-Tyr-NH2
Tau CAS
1114970-34-1
Tātai rāpoi
C39H61N11O8
Taumaha rāpoi
811.97
Hexapeptide-33 Related Research
The biological activities of Hexapeptide-33 are mostly mediated via the following mechanisms:
(1).Pro-Angiogenic
Na roto i te whakarei ake i te whakaongaonga o nga pūtau endothelial vascular, Ko te Hexapeptide-33 ka whakatere i te kiato microvascular mo te rere toto kiri pai ake me te kawe matūkai.
He painga tenei mo te kiri maroke, i te mea ka whakamarama i te uaua puhoi me te tere ake te whakatikatika i nga kiko.
Kei te whakaarohia ano hoki hei whakahou ake i te kaha o te kiri.
(2).Te Whakatairanga Collagen Synthesis
Ka taea e Hexapeptide-33 te whakahohe i te dermal fibroblasts me te whakanui i te collagen me te muka rapa whakahiato, na reira ka piki ake te ngawari o te kiri.
Ko etahi hautau hexapeptide kua whakaatuhia ki te whakanui ake i te whakaaturanga ira collagen me te whakaheke i te kaha o te whakahohenga. MMPs e whai wāhi ana ki te whakaroa i te koroheketanga o te kiri.
Nga toenga raupapa kakara, Pērā i te phenylalanine me te tyrosine i kitea he rite ano ki te whakaatu i te mahi whakaahuru me te kaha ki te hamuke tuwhena kore utu., te mutunga ka whakaiti whakaahua whakaahua nga paanga ma te tinei i nga rauropi kore utu na te ahotea photooxidative.
(3).Ka aukati te whakahiato melanin
E whakaponohia ana ko te kaha kanapa o Hexapeptide-33 na tona kaha ki te pokanoa tirosinase mahi, mana whakahaere ranei melanocyte tohu tohu.
Ko te Tyrosinase ka whakahaehae i te tyrosine ki dopa, katahi ki te dopaquinone me etahi atu eumelanin.
Ko te nuinga o nga peptides ma he anga tuara e rite ana ki nga peptides aukati tyrosinase maori ki te whakakore i te whākōkī me te depigment..
Ko te tyrosine moiety o Hexapeptide-33 me ona kaha rite ki a raatau ka taea te whakataetae tika ki te tyrosinase me nga kaiwhakawhiwhi whai hononga. (penei i te MC1R), e arahi ana ki te whakaheke i te whakahiato melanin.
(4).Whakapai ake i te Whakaora Whara me te Hekenga Pūtau
Ko nga toenga waikawa amino kua utaina pai penei i te Phe-Lys-Arg ka whakarei ake i te herenga peptide ki te membrane pūtau. glycosaminoglycans (e.g., chondroitin pūkawa), na reira ka roa te pupuri i te rohe.
Ka piki ake te mahi o nga enzymes, penei superoxide dismutase (SOD), he antioxidant tenei me te whakaheke i te tukunga o te ahotea oxidative me nga mea mumura na te hihi UV me etahi atu mea o waho..
I tua atu, ka whakatairanga i te heke keratinocyte me te rereketanga epidermal hei whakarei ake i te whakatikatika arai kiri, he mea pai mo te whakatika i te kiri kua pakaru, kiri tairongo ranei.
(5).Whakamutunga
Ko te Hexapeptide-33 e whakarato ana i nga painga tiaki kiri katoa i roto i te Maamaa-toru, Te tiaki korukoru me te punaha whakaora-whara.
Hexapeptide-33 whakamahi: Ko te Hexapeptide-33 he peptide bioactive ka taea te hoahoa ki te maha o nga serums / kirīmi anti-pakeke me te whakatika i nga whakaehunga / kanohi., hua kanapa/kokorikori, nga hanganga tiaki kanohi utu nui.
A he tino maha noa, ka taea e ia te whakaongaonga i te hanga collagen, whakatika i te arai kiri, aukati i te hanga melanin me te tarai porowhita āwangawanga.
COA
HPLC
MS
