Myristoyl Pentapeptide-4 is a biofunctional peptide that helps maintain skin fullness, දැඩි බව, and a youthful appearance.
It is designed based on mimicry and an intricate understanding of insulin-like growth factor-1 (IGF-1) and its role in regulating සෛල පැතිරීම, අවකලනය, ඇපොප්ටෝසිස් and synthesis of බාහිර සෛල අනුකෘතිය elements like collagen and elastin.
IGF-1 is not suitable for cosmetic use due to its large molecular weight that hinders penetration across skin, poor stability and high cost. By screening the critical receptor domains of IGF-1, the core sequence Lys-Thr-Thr-Lys-Ser was identified.
It also exhibits favorable tolerance in sensitive skin and has thereby become an essential active ingredient in topical anti-ageing dermatological formulations.
අනුපිළිවෙල
Lys-Thr-Thr-Lys-Ser (KTTKS)
CAS අංකය
1392416-25-9
අණුක සූත්රය
C37H71N7O10
අණුක බර
774.00
Myristoyl Pentapeptide-4 Related Research
1.Core Mechanism and Primary Effects
N-පර්යන්තය myristoylation significantly improved its lipophilicity and skin permeation, enabling the peptide to bind directly to IGF-1 receptors and activate downstream signaling.
මේ, පිළිවෙළට, reawakens age-related deceleration of anabolic cutaneous processes; it upregulates the synthesis rate of a variety of key extracellular matrix proteins such as I කොලජන් වර්ගය, Type III collagen and elastin – actively reversing dermal cell degradation caused by ageing.
This greatly increases the density and thickness of dermal tissue, demonstrating a potent ability to reduce or erase static wrinkles.
2.Facilitates Synthesis of Type I and III Collagen
Collagen type I and III are the key determinant proteins for skin elasticity and firmness.
Their natural synthesis capacity declines sharply with age.
Myristoyl Pentapeptide-4 functions by mimicking IGF-1 signaling, binding to the insulin-like growth factor-1 receptor and activating anabolic responses in fibroblasts.
This increases the production of Type I and III collagen, which thickens the dermis while reducing fine lines and wrinkles associated with ageing. 1
3.Boosts Elastin Synthesis and Organization
Myristoyl Pentapeptide-4 upregulates ඉලාස්ටින් ජාන ප්රකාශනය and protein production during fibroblast activation.
It stimulates newly produced proteins to organize into an ordered elastic fiber network, which reinforces the skin’s supporting layer.
This increases the elasticity of skin, quickly smoothing wrinkles resulting from loss of inner support, while also counteracting sagging.
Skin texture instantly becomes smoother, improving overall skin condition.
COA
HPLC
මෙනෙවිය
