Epithalon waa bioactive tetrapeptide lagu helay oo lagu safeeyey iyada oo loo marayo daraasado shaqayneed oo ku saabsan qanjirka pineal. Isku xigxiga amino acid gaar ah waa Ala-Glu-Asp-Gly.
Intii lagu jiray 1980-aadkii, Saynisyahanada Ruushku waxay sameeyeen cilmi-baaris habaysan oo ku saabsan doorka nidaaminta qanjidhada pineal ee hababka gabowga noolaha ee kala duwan.. Bioactive yar-molecule jajabyada peptide ayaa la go'doomiyay waxaana lagu sifeeyay qayb ka mid ah shaqadan;
Epithalon lafteeda ayaa laga soo saaray hal jajab oo firfircoon. Hagaajinta peptide-kan ayaa horseeday isku-dhafka macmalka ah ee lagu guuleystay.
Ka mid ahaanshaha qaybta aad loo qeexay ee peptides bioregulatory, Epithalon waxay si gaar ah u aqoonsan tahay noocyada qaarkood muujinta hiddaha iyo ku xiga hawlaha gacanta.
In vivo iyo noocyada kala duwan ee tijaabooyinka in vitro ayaa muujiyay in ay si gaar ah u dhaqaajiso muujinta telomerase reverse transcriptase (TERT) – qaybta catalytic ee telomerase – Kaas oo ah habka u dhow ee udub-dhexaadka caalamiga ah ee gabowga gacanta.
Telomerase soo koobo (iyo ilaa xad weyn magdhow) lumin dhererka telomere at koromosoomyada dhamaado; soo noqnoqda qaybinta unugga ayaa keena khasaarahan. Kordhinta dhererka telomere waxay si toos ah u wanaajisaa xadka taranka ee unugyada, hoos u dhigista dhammaan calaamadaha la xidhiidha’ ee gabowga dhabta ah ee gacanta.
Noocyada xayawaanku waxay muujiyeen saameyn weyn oo ka timid Epithalon: kordhinta nolosha nafleyda, ugu yaraan qayb ka noqoshada hoos u dhaca jireed ee da'da, hab-dhiska difaaca, xannibidda (qaar) tumorigenesis, iyo ilaa heer soo celinta dheelitirka endocrine.
Wax ka beddelka tibaaxaha hidde-sidaha muhiimka ah iyo haysashada (ilaa heer) sifooyinka antioxidant ayaa la rumeysan yahay inay yihiin sababaha asaasiga ah ee dhammaan kuwa kor ku xusan. Epithalon, taasoo keentay, waxay ahaanaysaa xarun bioactive aadka loo qaddariyo ee dhammaan khadadka cilmi-baarista gabowga ka-hortagga.
Isku xigxiga
H-Ala-Glu-Asp-Gly-OH
Lambarka CAS
307297-39-8
Qaanuunka molecular
C14H22N4O9
Miisaanka Molecular
390.35
Cilmi-baarista Epithalon
1.Saamaynta gabowga
Telomeres waa dhismayaal DNA-protein gaar ah oo ku yaal cidhifyada koromosoomyada eukaryotic. Shaqadooda asaasiga ahi waa ka ilaalinta dhamaadka koromosoomyada in loo aqoonsado dhaawaca DNA; ka hortagga nooc kasta oo nabaad-guurka koromosoomyada waa muhiimad weyn. Qayb kasta oo unug kastaa waxay keentaa in telomeres-yadan ay yara gaabiyaan.
Gaadhida dhererka ugu yar waxa ay kicisaa soo celin caqli-galnimo ama hababka jawaab celinta dhaawaca DNA ee kala duwan; xidhitaanka qaybta unugga (gaar ahaan at the G1 waji) iyo dheecaanka xiga ee dhowr hormoonno oo la xidhiidha gabowga gacanta ayaa ah natiijada ugu dambeysa.
Telomerase, a ribonucleoprotein dib u rogida, waxa uu kor u qaadaa isku-xidhka DNA-ga telomere-kan oo uu dib ugu daro dhamaadka koromosoomka – magdhowga gaabintii hore. Epithalon wuxuu si gaar ah u hawlgeliyaa hidda-wadaha TERT ee ka mas'uulka ah hawshan, asal ahaan nidaaminaya telomerase.
Daraasadaha moodooyinka xayawaanku waxay muujiyeen cirbadaha xilliyeed si loo kordhiyo cimriga, dib u dhigista dhinacyo badan oo hoos u dhaca jireed ee la xidhiidha da'da, dhimo (dhameystiran dhow tirtirid) pathologies kala duwan ee gabowga, iyo dhammaan hareeraha habaynta dariiqyada miyir-qabka ee muhiimka ah.
2.Antioxidant iyo saamaynta anti-bararka
Drosophila melanogaster waa nooc si fiican loo aasaasay oo lagu qiimeeyo peroxidation lipid heerarka. Inta lagu jiro marxaladda dirxiga ku darida 0.00001% Epithalon waxay si guul leh u joojisay kororka la filayo ee peroxidation. Antioxidant awood leh iyo ilaa xad weyn saamaynta anti-bararka ayaa lagu muujiyay natiijadan.
Daraasad gaar ah oo lagu eegayo uruurinta kala duwan ee Epithalon ee horumarka hore ayaa lagu ogaaday in qaangaarka iyo da'da weyn ay u duulaan inay yihiin qaataha koowaad ee saameynteeda.. Genotoxicity lama arkin.
3.Suurtogalnimada Antitumor
Epithalon waxa ay yaraynaysaa xasilooni darada koromosoomyada; Tirtirka koromosoomyada iyo noocyada kala duwan ee isu beddelka ayaa si toos ah u saameeya DNA-da noolaha. Deficiency DNA ayaa caadi ahaan ah sababta koowaad ee unugyada gacanta kansarka.
Daraasad laba indhoole ah oo muddo dheer socotay ayaa muujisay hoos u dhac toos ah oo ku yimid dhacdooyinka burooyinka iyo kala duwanaanshaha daaweynta Epithalon.. Door firfircoon oo lagu xakameynayo dhinacyo badan oo gaar ah oo horumarinta burooyinka ayaa sidoo kale la arkay. Daweynta burooyinka cabbirka iyo goobta isku midka ah, daawaynta muddada-dheer ee Epithalon waxay keentay korriin buro ah oo aad u yar.
4.Saamaynta Nidaaminta Endocrine
Epithalon waa wakiil noole awood u leh inuu si weyn u saameeyo habdhaqanka unugyada endocrine ee caloosha.
Tijaabo la adeegsanayo jiirka da'da dhexe ayaa arkay qanjidhada pineal oo laga saaray maadooyinka; kooxda tijaabada ah waxay heleen maamulka Epithalon oo joogto ah. Tirinta unugyada gastrin-soo-saarka iyo somatostatin-soo-saarka unugyada waxay muujisay ilaalin ku dhow dhow ee la rabo. unugyada endocrine noocyada marka la barbar dhigo kantaroolka. Yaraynta luminta dhammaystiran ee unugyadan ka dib ka saarista pineal waa calaamad cad oo ah saamaynta Epithalon ee ugu yaraan nooc ka mid ah habdhaqanka unugyada endocrine..
5.Dib-u-soo-noolaynta unugyada iyo shaqada dayactirka
Epithalon waxay soo bandhigaysaa wax la mid ah retinoids. Baarista qaabdhismeedka unugyada isha ee jiirarka da'da dhexe, Daawaynta Epithalon oo joogto ah ayaa ilaalisay dhammaan qaab-dhismeedka xuubka isha; Burbur dhammaystiran ee isha ayaa lagu arkay jiirarka aan la daweyn.
Lakabyada laf-dhabarka ee lagu daweeyay Epithalon ayaa la ilaaliyay daacadnimo, kororka waxa lagu tilmaami karo oo kaliya 'aagagga dhaqdhaqaaqa shaqeeya'. Tijaabo caafimaad oo bukaannada ah (162 wadarta guud, da'da kala duwan) oo leh retinitis pigmentosa ayaa hadda la raacayaa; hagaajinta acuity aragga ee 0.15-0.25 ayaa la sheegay, oo ay la socdaan dhammaan daboolida goobta muuqaalka wareegsan (ilaa heer). Waxyeellooyinka soo raaca lama soo sheegin.
6.Hagaajinta Shaqada Metabolic
Gudaha 2004, Tijaabo kale oo lagu sameeyay daanyeerka macaque ayaa muujisay saamaynta Epithalon gaar ahaan heerarka gulukooska dhiigga. Daanyeerrada yaryar iyo kuwa da'da ah ayaa la siiyay cirbadaha Epithalon ee muruqyada; qiyaasaha gulukoosta dhiigga ee xiga ayaa la qaaday.
Kahor maamulka, Daanyeerrada da'da ah waxay muujiyeen in heerarka gulukoosta dhiigga ee bilowga ah aad u sarreeya. Cabbiraadaha qaadashada ka dib ayaa muujiyay hoos u dhac cad oo muuqda oo heerarkan ah daayeerradii hore. Ku soo noqoshada gundhigga (ugu yaraan si ku meel gaar ah) waxaa la arkay hal bil kadib markii la joojiyay maamulka.⁶
7.Xeerka Nidaamka Difaaca
Daraasado la adeegsanayo dhaqamada organotypic ee jiirka aasaasiga ah ee fibroblasts iyo maqaarka jiirka ee kala duwan ayaa muujinaya nooc ka mid ah nidaamka hab-dhiska difaaca ee nidaamka difaaca ee Epithalon soo bandhigo., ugu yaraan gudaha unugyada maqaarka.
Falanqaynta unugyada la daweeyay ayaa muujisay korortay (si weyn sidaas) SOD-1 iyo NQO1 muujinta – Labaduba si wanaagsan ayaa loo diiwaangeliyay calaamadaha antioxidant/enzymatic. Kor u qaadida noocaan 'difaaca’ ama ugu yaraan ilaalin, shaqada nidaamintu waa wax ay saynisyahannadu ku tilmaameen natiijo wanaagsan.
8.Ilaalinta Neuro iyo Kobcinta Garashada
Awoodda wax-barashadu waxay ahayd diiradda daraasado dhowr ah; ilaalinta iyo hagaajinta neerfayaasha (saamaynta antioxidant oo qayb weyn ka ah habkan, oo ay la socoto neurotransmitter khiyaano badan iyo hagaajinta la xiriirta neurotrophic ee muddada-dhow) waa waxa Epithalon uu awoodo inuu gaaro.
Awood waxbarasho oo la wanaajiyey ee daanyeerka da'da ah waa natiijo toos ah dhammaan arrimaha kor ku xusan.
COA
HPLC
MS
