I-Dipeptide-2 iyi-dipeptide esebenzayo ekuqaleni eyafundwa kabanzi ngemiphumela yayo yokulwa nokuguga embonini yezimonyo.. Elinye igama elithi 'Ijwabu leso’ ibhekisela ngokukhethekile ekusetshenzisweni kwayo okuqondiswe kakhulu; ukuthuthukisa izinkinga ezihlukahlukene zesikhumba zamehlo – Izikhwama zangaphansi ziyisibonelo esihle, imibuthano emnyama ingenye.
Ukulandelana
I-Val-Trp
Inombolo ye-CAS
24587-37-9
I-Molecular Formula
I-C16H21N3O3
Isisindo samangqamuzana
303.36 g/mol
Ucwaningo lwe-Dipeptide-2
Ngaphakathi kwesayensi yezimonyo, I-Dipeptide-2 ihlukaniswa njenge-peptide ye-bioactive enamandla okulwa nokuguga. Ukunakekelwa kwesikhumba okulwa nokuguga kuye kwaphusha ama-peptide e-bioactive ahamba phambili ekuthuthukisweni kwesimanje; isisindo samangqamuzana amancane, eqinile (ngezinga elithile) amakhono okukhomba, kanye nokungena kahle kwesikhumba konke kunomthelela ekudumeni kwazo. I-bioactivity eyinhloko ye-dipeptide-2 ngokwayo ivela i-angiotensin-ukuguqula i-enzyme (I-ACE) ukuvimbela impahla. Lokhu kwakha isisekelo setiyori esiseduze esiphelele sanoma yikuphi ukusebenza kahle kwezimonyo esingase sikubonise, Ukukhathazeka kwesikhumba okuhlobene nokujikeleza kungenye yezinhlelo zokusebenza eziqondile.
I-Angiotensin-Converting Enzyme (I-ACE) i-zinc metallopeptidase eyinhloko; ithuthukisa ukuguqulwa kwe-Angiotensin I ibe yi-vasoconstrictor enamandla Angiotensin II (uhlelo lwe-renin-angiotensin olubhekele le nqubo). Angiotensin II njengoba kushiwo, kubangela vasoconstriction, umfutho wegazi ophakeme, ukugcinwa kwamanzi okungenzeka.
A 2015 funda ngokuhlukanisa ngempumelelo i-dipeptide-2 kunhlanzi yolwandle olujulile amaprotheni hydrolyzate, iqinisekisa amandla ayo okuvimbela i-ACE – Amanani e-IC50 abikiwe, iphansi ngokwanele ukukhombisa umsebenzi oqinile we-in vitro. Ubufakazi obucacile be-in vitro balokhu kuvinjelwa kwe-ACE bukhona.
Ukuqinisekisa umsebenzi ongenhla ohlobene ne-ACE, ucwaningo olufanayo luphinde lwakhomba izakhiwo zalo zokulwa ne-antioxidant. Ukucindezeleka kwe-oxidative kuyindlela eyinhloko yangaphandle yokuguga kwesikhumba; Izinhlobo ze-oxygen esebenzayo ngokweqile zilimaza zonke izingxenye zamangqamuzana (I-DNA, amaprotheni, lipids) futhi wenze kusebenze ama-enzyme awonayo we-matrix engaphandle kweseli. I-Val-Trp, okungenani ngokwengxenye, ivikela ingqamuzana lesikhumba kulolu hlobo lomonakalo – imiphumela elwa nokuguga yamahhala iyindlela ehambisanayo ebalulekile komunye wayo (futhi kubhalwe kahle) izinzuzo.
Ngokuncintisana ngokuvimbela umsebenzi we-ACE, I-Dipepetide-2 yehlisa ukukhiqizwa kwe-angiotensin II. I-Vasoconstriction kanye ne-edema yendawo elandelayo iyancipha ngokuqondile ngalokhu kuncipha.
Lo mshini ubaluleke kakhulu ekunakekeleni isikhumba; Ukuvinjelwa kwe-ACE kwehlisa ngokuqondile amandla e-capillary permeability, ukuvimbela izinhlobo ezithile zokunqwabelana koketshezi. Ukuthuthukiswa kwe-lymphatic drainage kuwumphumela oyinhloko wale nqubo, ngokuvuvuka kwe-periorbital kanye nezinhlobo ezahlukene ze-hyperpigmentation ezincishiswa ngokuphawulekayo. I-microcirculation ethuthukisiwe ngokwayo iletha umoya-mpilo ongcono kanye nokulethwa kwezakhi ezijwayelekile ezicutshini zesikhumba – impilo yeselula kanye nobungqabavu obuseduze obuhlala buba umphumela wokugcina.
Ukumangalela ukuthi i-dipeptide-2 (esimweni sokunakekelwa kwamehlo) ‘ingaqeda izikhwama zamehlo, imibuthano emnyama, kanye ne-edema ehambisanayo’ iwukusetshenziswa okunesisekelo esiqinile kwalo mkhakha wokucabanga.
I-Dipeptide-2 iyisithako esivame kakhulu ngaphakathi kwe-skincare ye-premium anti-aging, okhilimu wamehlo eyisibonelo esihle. I-Periorbital edema futhi okungenani ezinye izici zemibuthano emnyama zincishiswa ngokuthembekile yiyo. Ukuqinisa umgoqo wesikhumba kanye nawo wonke ama-hydration ayindilinga angeziwe, izinzuzo ezibikwe kahle.
Izifundo zemitholampilo zisekela konke ukuthuthuka okukhulunywe ngenhla; ukuqina nokucwebezela kuyiziphetho ezingalinganiseka zokuphumelela kokwelashwa.
I-COA
I-HPLC
MS
