I-Dipeptide-6 iyi-dipeptide eyakhiwe nge-peptide bond exhumanisa i-proline (UPro) futhi i-hydroxyproline (I-Hyp). Kubhekwa njengenye yezingcezu ze-peptide eziyinhloko ezikhiqizwa ngesikhathi sokugaya kanye nokuwohloka okulandelayo kwe-collagen emzimbeni womuntu., isebenza njenge-biomarker eseduze njalo ye-collagen metabolism. IHydroxyproline ngokwayo i-amino acid ehlukile ku-collagen; ukuzinza kanye nezinhlobo ezahlukahlukene zomsebenzi webhayoloji ezihlotshaniswa nale dipeptide zincike kakhulu ebukhoneni bayo – ukugcina okungenani ubuqotho besakhiwo sesikhumba kube omunye womphumela onjalo.
Ukulandelana
H-Pro-Hyp-OH
Inombolo ye-CAS
18684-24-7
I-Molecular Formula
C₁₀H₁₆N₂O₄
Isisindo samangqamuzana
228.25 g/mol
Ucwaningo lwe-Dipeptide-6
I-Collagen iyiphrotheni eyinhloko yesakhiwo etholakala ezicutshini eziningi ezixhumeneyo (isikhumba, amathambo, i-cartilage iyisibonelo esihle). Ukulandelana okuphindayo kwesici (Gly-X-Y, X/Y futhi ngokuvamile Pro noma Hyp) nikeza lezi zicubu ukunwebeka kwazo ezikufunayo kanye namandla omshini ayindilinga. IHydroxyproline njengoba kushiwo yilokho okuchaza i-amino acid, okuqukethwe kwayo kuwukubonakaliswa okuseduze kwesikhathi sangempela kwesimo somzimba wamanje we-metabolic mayelana ne-collagen.
IHydroxyproline equkethe izingxenye ze-peptide iyingxenye ebalulekile ye-bioactive yanoma iyiphi i-peptide etholakala ku-collagen – I-Pro-Hyp namafomu ahlobene abhalwa kahle. Ukuphatha ngomlomo kuvumela izinga elithile lokumunca, ukungena egazini ukuze okungenani kulawule ukusebenza kwe-fibroblast yesikhumba.
I-Dipeptide-6 iyi-peptide eyenzeka ngokwemvelo, ethathwe ku-collagen eshiwo. I-collagen etholakala ezilwaneni (isikhumba sezinhlanzi, inkomo njll.) igayeka kokubili umuntu kanye nezimboni/i-hydrolysis; amaketanga amade aphuka abe ama-peptide amancane, I-H-Pro-Hyp-OH ingenye yemikhiqizo yokugcina ye-bioactive etholakala kalula.
Ucwaningo ngendlela yayo njengamanje lukhomba emiphumeleni yokulwa nokuguga ye-dipeptide-6 njengokuhlobene ngqo nokugqugquzelwa kokukhula kwe-fibroblast nomsebenzi..
Ukukhuthaza Ukusabalala kwe-Fibroblast kanye ne-Collagen Synthesis: Ama-Fibroblasts ayizimboni eziyinhloko’ obhekene nokuhlanganisa i-scaffolding yesikhumba kanye nezingxenye ze-hydrating; i-collagen, i-elastin, kanye ne-hyaluronic acid njengezibonelo ezibhalwe kahle kakhulu. Umsebenzi wabo osebenzayo wehla kakhulu ngokuya ngeminyaka.
Izifundo eziningi ze-in vitro zikhombisa ngokungaguquki ukuthi i-Dipeptide-6 yenza kusebenze ngempumelelo ukwanda kwe-fibroblast kanye nokufuduka okulandelayo.. Ucwaningo lukhomba ngokuqondile i-Dipeptide-6 ekhuthaza lokhu kwanda nokukhula – igundane kanye ne-fibroblasts yesikhumba somuntu kokubili esabela kuyo.
Isici se-chemotactic siyabonwa, ama-fibroblasts akhangwa ukuya ezindaweni ezithile; ukulungiswa kokulimala kwesikhumba kanye nezinhlobo ezihlukahlukene zokuvuselela izicubu kuncike kule nqubo.
I-Dipeptide-6 ikhonjiswe ukuthi ithuthukisa kakhulu umsebenzi we-hyaluronic acid synthase ngaphakathi kwe-fibroblasts. Okuhlobene ngqo nalokhu okungenhla, ngcono ukugeleza kwamanzi esikhumbeni (i-plupper, ukubukeka okuseduze kwamazolo) imiphumela yokwanda kokukhiqizwa.
A okungahleliwe, izimpumputhe ezimbili, isilingo somtholampilo esilawulwa yi-placebo sisebenzisa ukwakheka okuphezulu kwe-collagen peptide okuqukethe i-Pro-Hyp kubonise ukuthuthukiswa kokugeleza kwesikhumba sobuso, ukunwebeka, imibimbi nama-roughness metrics ngaphezulu 8 amasonto.
Ukuphromotha Ukwenziwa Kabusha kwe-ECM kanye Nokulungiswa Kabusha: Ukwenza kusebenze ama-fibroblasts njengoba kushiwo ngenhla, ukuvuselelwa kwe-ECM engaqondile kuwumphumela oyinhloko. Ukulungiswa kwamaprotheni athile e-ECM (thayipha I-collagen ibe isibonelo esiyinhloko, kanye ne-elastin ne-fibronectin) kubikiwe izinga lofuzo.
Ukuvinjelwa kwe I-Matrix Metalloproteinase-1 (I-MMP-1) Inkulumo: Ukwengezwa komlomo kwe-collagen peptide kuholela ekwandeni kwamazinga e-plasma I-Gly-Pro kanye nawo wonke ama-dipeptide ahlobene; ukunciphisa i-MMP-1 eyenziwe yi-UVB kungenye yezindawo zokugcina ezilinganiseka kakhulu zale ndlela.
I-Dipeptide-6, ngazo zonke izindlela, iyisilawuli sangempela se-multifaceted of skin physiology. Ukuguga kobuso kungenye yezinzuzo eziningi ezingaba khona ze-Pro-Hyp noma ama-dipeptide afanayo.
I-COA
I-HPLC
MS
