Peptide CRO Advantage
Classe 100 sterile laboratory
Organic Chemistry Specialist
Available in mg-kg grade
Purity from crude to 99%
Multi-modal study routes
Peptide CRO Core Services
Technology development; process mapping.
Design and Synthesis
Customized peptide synthesis
Synthesize peptides of specific sequences (e.g. linear peptides, cyclic peptides, modified peptides, etc.) according to customer requirements.
Modification types
phosphorylation, acetylation, biotin labeling, fluorescent labeling (FITC, Cy series), PEGylation, etc.
Special structural peptides
disulfide-bonded cyclic peptides, multimeric peptides, membrane-penetrating peptides (CPP), glycosylated peptides, etc.
Peptide library construction
Provide combinatorial peptide libraries (e.g. phage display libraries, solid phase synthesis libraries) for high throughput screening.
Process Development
Route design
Chemical synthesis method (solid phase synthesis SPPS, liquid phase synthesis): for short peptides (usually ≤50 amino acids), need to select protection group strategy, coupling reagents, etc.
Biosynthesis (recombinant DNA technology): expression of long peptides or complex modified peptides by microorganisms or cells, requires optimization of host selection (e.g. E. coli, yeast) and culture conditions..
Process optimization
Synthesis/expression optimization: increase yield (e.g. temperatura, pH, catalyst concentration).
Purification process: chromatography (reversed-phase HPLC, ion exchange) is key, need to optimize elution conditions.
Impurity control: remove missing peptides, mismatched sequences, oxidation products, etc. to ensure purity (usually >98%).
Delivery support and technical assurance
Strict standards are enforced at every step of the process
Technology
Core Assurance
- aseptic laboratory
- nitrogen protection
- Per-step testing
- Organic Chemistry Specialist
Orders
Included Services
- HPLC;MS;Ph Reports
- Free desalting and transsalting
- Optional dissolution testing
- Optional endotoxin testing
