AHK yog ib qho tripeptide uas muaj peb cov amino acids: alanine (Ala), histidine (Nws) thiab lysine (Lys).
Qhov no me me peptide muaj zoo heev transdermal nqus tau.
Nws yog ntseeg hais tias vim yog cov amino acids nrog electron-dawb pab pawg, zoo li histidine thiab lysine tshwm hauv nws cov qauv, Nws tuaj yeem tshem tawm cov dawb radicals thiab tiv thaiv lipids los ntawm peroxidation thiab tawm dag zog antioxidant muaj nuj nqi.
Ob qho tshuaj synthesis thiab muab cais nyob ib leeg los ntawm proteolysate ntawm natural proteins (e.g., marine shellfish, mis nyuj protein) tam sim no muaj peev xwm tsim AHK.
Nyob rau hauv sib piv rau feem ntau ntawm macromolecular antioxidants, AHK muaj qhov hnyav dua molecular thiab zoo dua biocompatibility, uas tej zaum yuav tsim nyog raws li ib tug cosmetic active.
Ib ntus
Ala-His-Lys
CAS Nr
126828-32-8
Molecular Formula
C15H26N6O4
Molecular Luj
354.40
AHK Kev Tshawb Fawb Txog Kev Tshawb Fawb
Lawv tshwj xeeb yog txaus siab rau kev ua haujlwm antioxidant thiab npaj siab tias: Cov txiaj ntsig tseem ceeb ntawm AHK yog vim nws cov kev ua haujlwm antioxidative, uas yog generated los ntawm cov nram qab no ua sequences:
1.Kev khawb av ROS
ROS yog ib qho ntawm cov culprits tseem ceeb tshaj plaws ua rau cellular oxidation thiab aging ntawm daim tawv nqaij.
Kev hloov pauv ncaj qha ntawm electrons los yog hydrogen atoms kom dawb radicals lawv tus kheej rau ROS inactivation los ntawm ntau antioxidant peptides, ua rau tshem tawm ROS.
Cov histidine thiab lysine residues ntawm AHK tuaj yeem pub hydrogen atoms lossis electrons los tua ROS radicals (DPPH, ABTS) ncaj qha mus txiav oxidative chain reactions.
Nws tau raug tshaj tawm tias histidine-muaj peptides tuaj yeem tshem tawm cov radicals ntawm SET (Ib qho hluav taws xob hloov) los yog HAT (Hydrogen Atom Hloov) txheej txheem.
2.Ua kom cov Endogenous Antioxidant Systems
Qee cov antioxidant peptides kuj nce cellular anti-oxidative muaj peev xwm los ntawm stimulating tseem ceeb intracellular anti-oxidases (e.g., superoxide dismutase SOD, glutathione peroxidase GSH-Px)².
Hauv qee cov qauv ntawm tes, AHK-hom peptides tuaj yeem txhim kho qhov kev qhia ntawm endogenous antioxidant enzymes xws li SOD thiab GSH-Px, uas tuaj yeem ua kom yooj yim rau kev tiv thaiv cellular tiv thaiv oxidative kev nyuaj siab.
3.Hlau Ion Chelation
Cov imidazole Lub nplhaib ntawm histidine thiab cov amino pawg ntawm lysine tuaj yeem ua haujlwm nrog Hloov cov hlau ions (xws li Fe²⁺, Cu²⁺), uas yuav attenuate hlau-catalyzed Fenton reactivity, yog li ua rau inhibition ntawm hydroxyl radical tsim ⁴.
Nws cov tooj liab ion complex (AHK-Cu, nquag hu ua GHK-Cu los yog tooj liab tripeptide-1) –tsis yog AHK ib leeg– muaj kev tsim thiab pom zoo siv hauv tshuaj pleev ib ce.
Tau txais txiaj ntsig ntawm antioxidant, collagen regeneration induction thiab kho sai, AHK tau siv rau ntau hom khoom siv tawv nqaij.
4.Rau txhua yam anti-aging serum thiab cream khoom
Tightening xoob ntawm daim tawv nqaij thiab txo wrinkles los ntawm txhawb collagen syntonyization & tiv thaiv oxidative kev nyuaj siab.
5.Rau kev kho mob tom qab phais lossis qhov txhab kho tshuaj pleev ib ce
Txhawb cov txheej txheem kho epidermial thaum txo cov kev txhawj xeeb txog kev kho mob.
Nyob rau hauv tawv taub hau thiab plaub hau tshuaj pleev ib ce: Cov kev tshawb fawb tau ua pov thawj nws lub peev xwm ntawm kev txhawb nqa angiogenesis ib ncig cov hauv paus plaub hau kom ua tiav cov plaub hau loj hlob& ua rau nws muaj peev xwm rau cov tshuaj zawv plaub hau los tiv thaiv kev loj hlob.
Tsis tas li ntawd xwb, hauv cov tshuaj antioxidant, AHK muaj peev xwm ntxiv cov txiaj ntsig rau cov khoom xyaw xws li Vitamin C thiab E, Txhim kho qhov tshwj xeeb dav dav los tiv thaiv oxidant network cuam tshuam ntawm kev tu tawv nqaij uas tuaj yeem txhim kho kev tiv thaiv * 1 thiab kho cov haujlwm ntawm daim tawv nqaij.
COA
HPLC
MS
