Pancragen ndi bioactive synthetic peptide yopangidwa ndi ma amino acid anayi.
Kafukufuku wokhudza ntchito ya kapamba adapangitsa asayansi kupeza a mahomoni-monga gawo logwira ntchito mkati mwa pancreatic extracts; kulimbikitsa kapamba palokha kukhala choyambirira chowonedwa.
Maonekedwe enieni a hormone iyi poyamba sankadziwika bwino.
Zowonjezera mu biology ya maselo ndipo kenako ukadaulo wa peptide synthesis unalola kufananizidwa kwake kolondola – kukhathamiritsa kosalekeza ndi kusinthidwa kwachidutswa chapakati kuchokera ku chotsitsa choyambirira kukhala njira yomwe Pancragen idapangidwira..
Post-kaphatikizidwe, Phindu lalikulu la kafukufuku wachipatala linaperekedwa ndi izo.
Kupititsa patsogolo kukhazikika kwa minofu ya pancreatic, kulimbikitsa kukonza, ndi kuyang'anira metabolic homeostasis ndi zabwino zake zolembedwa bwino.
Yotakata odana ndi kutupa komanso zoteteza zimawonekeranso mkati mwa chiwindi, impso, mantha dongosolo ndi ziwalo zina.
Kutsatizana
H2N-Lys-Glu-Asp-Trp-OH
Nambala ya CAS
/
Molecular Formula
Chithunzi cha C26H36N6O9
Kulemera kwa Maselo
576.607
Kafukufuku wa Pancragen Peptide
1.Chitetezo ndi Kubadwanso Kwatsopano kwa Pancreatic β-maselo
Kuchepa kwa ma cell awa ndiye gawo lalikulu la pathological matenda a shuga.
Kutengera kukula kwa endo native kapena ma siginecha opulumuka, Kuletsa apoptosis ndi njira yofunika kwambiri; kuteteza (osachepera kwakanthawi) ma cell a beta ndikupanga microenvironment yothandizira kusinthika kwa ma cell.
Miyezo yokhazikika ya glucose imasungidwa, mosalunjika kudzera bwino zotumphukira minofu insulin sensitivity – kuchepetsa kukana kwa insulini ndi kukulitsa zinthu zosiyanasiyana ntchito ya mitochondrial.
Pancragen imayendetsa njira zopulumukira zomwe zatchulidwa kale (PI3K/Act ndi MAPK/ERK).
Kuyambitsa njira za apoptotic pansi pa kuukira kotupa kumaletsedwa bwino.
Mayesero azachipatala pano akufufuza kusinthika kwenikweni kwa ma cell ngati pomaliza.
Kulimbikitsa magawano ndi kuchuluka kwa maselo osachepera ena, kuphatikiza ndi microenvironment yomwe tatchula kale, zimayimira kusintha kwakukulu kwa matenda a shuga.
2.Metabolic Regulation (monga pamwamba)
Kuwongolera mwadongosolo kwa kukhudzidwa kwa insulin kumawonedwa m'zinyama.
Cytoprotection amachepetsa kwa chiwindi ndi minofu ya adipose kutupa kosatha.
Zotsatira zachindunji ndi zosalunjika pa insulin receptor ndi zochitika za transporter zonse ndi gawo lakusintha kwamphamvu kwa insulin.
Antioxidant ndi anti-yotupa zotsatira za Pancragen ndizofunika kwambiri pakufufuza.
Neuropathy ndi metabolic syndrome mtundu kuwonongeka, kapena matenda aliwonse okhudzana ndi kupsinjika kwa okosijeni, akhoza ndipo ayenera kupindula ndi ntchito za Pancragen.
COA
Mtengo wa HPLC
MS
