Pancragen is a bioactive synthetic peptide composed of four amino acids.
Research into pancreatic function led scientists to discover a hormone-like active component within pancreatic extracts; stimulating the pancreas itself being the primary observed effect.
The exact composition of this hormone was initially unclear.
Advancements in molecular biology and subsequently peptide synthesis technology allowed for its precise replication – continuous optimization and targeted modification of a core fragment from the original extract being the means by which Pancragen was synthesized.
Post-synthesis, significant clinical research value was attributed to it.
Enhancing pancreatic tissue stability, promoting repair, and regulating metabolic homeostasis are its well documented primary benefits.
Ampio anti-inflammatory and protective effects are also seen within the liver, kidneys, nervous system and other organs.
Sequenza
H2N-Lys-Glu-Asp-Trp-OH
Numero CAS
/
Formula molecolare
C26H36N6O9
Peso Molecolare
576.607
Research Of Pancragen Peptide
1.Protection and Regeneration of Pancreatic β-Cells
Depletion of these cells is the core pathological factor in diabete.
Mimicking endogenous growth factors or survival signals, inhibition of apoptosis is a key mechanism; protecting (almeno temporaneamente) beta cells and creating a supportive microenvironment for cell regeneration.
Stable blood glucose levels are maintained, indirectly through improved peripheral tissue sensibilità all'insulina – reducing various aspects of insulin resistance and enhancing funzione mitocondriale.
Pancragen activates those previously mentioned survival pathways (PI3K/Akt E MAPK/ERK).
Initiating apoptotic pathways under an inflammatory attack is successfully inhibited.
Clinical trials are currently investigating true cellular regeneration as an end point.
Stimulating division and proliferation of at least some cells, combined with the earlier mentioned microenvironment, represents a fundamental reversal of diabetes progression.
2.Metabolic Regulation (as above)
Systemic improvement of insulin sensitivity is seen in animal models.
Cytoprotection reduces hepatic and tessuto adiposo chronic inflammation.
Direct and indirect effects on insulin receptor and transporter activity are all part of the overall improvement in insulin sensitivity.
Antiossidante and anti-inflammatory effects of Pancragen are of significant research value.
Neuropathy and sindrome metabolica type damage, or any disease related to stress ossidativo, can and should benefit from Pancragen therapeutic applications.
COA
HPLC
SM
