Hexapéptido — 33 (secuencia: Ser — Phe — Lys — Leu — Arg — Tyr — NH₂, SFKLRY; W3 péptido) ge 'nar péptido hexa — aminoácido.
'me̲t'o creado ya tecnología Novacell a través de biblioteca peptídica tecnología, 'me̲hna bí 'yo̲t'e pa njapu'befi cosmético ne pe̲ts'i varios njapu'befi ar cuidado ar piel: mfeni ar inducir angiogénesis; mejorar ar elasticidad ar piel; reducir arrugas; ne mejorar función barrera.
Nuna ar péptido ejerce yá efectos a través de ar unión ma G — proteína acoplados receptores (GPCRs) ampliamente expresado jar células humanas, particularmente jar piel queratinocitos ho participa ja ya procesos diferenciación epidérmica.
ar precisamente nu'bya ar ntsuni ne eficacia Hexapéptido — 33, ar xi convertido ja 'nar ingrediente mpa jar xingu productos ar cuidado ar piel anti-envejecimiento yá abrillantador yá reparación.
Secuencia
Ser — Phe — Lys — Leu — Arg — Tyr — NH2
'bede ya CAS
1114970-34-1
Fórmula molecular
C39H61N11O8
Be̲xu molecular
811.97
Hexapéptido — 33 relacionados ár nthoni
The biological activities of Hexapeptide-33 are mostly mediated via the following mechanisms:
(1).Pro-Angiogenic
Through enhanced stimulation of vascular endothelial cells, Hexapeptide-33 accelerates microvascular density for superior skin blood flow and nutrient transport.
This is beneficial for dry skin, as it brightens dull complextion and speeds up tissue repair.
It is also thought to rev up the skin’s metabolic vigor.
(2).Promoting Collagen Synthesis
Hexapeptide-33 can activate dermal fibroblasts and increase collagen and elastic fiber síntesis, thus increasing skin compactness.
Some hexapeptide fractions have even been shown to increase the collagen gene expression and decrease the excess activation of MMPs which contributes toward delaying dermal ageing.
Aromatic sequence residues, such as phenylalanine and tyrosine were also found similarly to display antioxidation activity with free radical scavenging capacity, ultimately reducing fotoenvejecimiento effects by quenching free radicals due to photooxidative stress.
(3).Melanin synthesis inhibited
Hexapeptide-33’s brightening potential is believed to come from its ability to interfere with tyrosinase activity, or control melanocyte signaling.
Tyrosinase oxidizes tyrosine to dopa, then to dopaquinone and so on to eumelanin.
Most of the whitening peptides have backbone structure similar to natural tyrosinase inhibitory peptides to inactivate enzyme and depigment.
The tyrosine moiety of Hexapeptide-33 and its basic analogous capabilities with them can effectively compete with tyrosinase or related receptors (such as MC1R), leading to a reduction in melanin synthesis.
(4).Mejorada cicatrización heridas ne migración celular
residuos aminoácidos cargados positivamente komongu ar Phe — Lys — Arg mejoran ar unión peptídica ma membrana celular glicosaminoglicanos (e.g., sulfato condroitina), prolongando nja'bu̲ ar retención ja.
'me̲hna aumenta ar nt'ot'e ya enzimas, tales com superóxido dismutasa (SOD), da ge 'nar antioxidante ne disminuye ar liberación ar estrés oxidativo ne factores inflamatorios inducidos ir nge ar radiación UV wa ma'ra factores exógenos.
adicionalmente, promueve migración queratinocitos ne diferenciación epidérmica pa mejorar ar reparación ar barrera ar piel, nä'ä ar ideal pa reparar piel dañada wa sensible.
(5).Njäts'i nu'bu
Hexapéptido — 33 proporciona njapu'befi Nxoge ar hñeti ar piel ja 'nar blanco triple modo, Wrinkle — care ne ko ya cicatrización heridas.
Hexapétido — 33 usos: Hexapeptide-33 is a versatile bioactive peptide that can be designed into many anti-aging serums/creams and repair emulsions/masks, brighten/spot-fade products, premium eye care formulations.
And it is just so versatile, it can stimulate collagen production, repair the skin barrier, block melanin production and tackle periorbital concerns.
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