Myristoyl Hexapeptide-16 is a synthetic lipopeptide. Synthetically, it is formed by covalently conjugating myristoyl to the N — terminus of hexapeptide-16.
Originating from a naturally secreted alkaline queratina-associated peptide within hair follicles, the natural peptide itself has short skin retention time and poor membrane penetration – a limitation addressed through lipid modification.
The introduction of the myristoyl group provides a hydrophobic tail capable of inserting into both membranas celulares nehmä stratum corneum; significantly enhanced membrane permeabilidad is the direct result.
Wide usage in various eyelash serums, anti-hair loss products and post-surgical repair creams demonstrates its utility. Its profile as a safer keratin-regulating agent (prostaglandin analogues being the primary comparison) ge 'na yá ndu'mi ventajas.
Secuencia
Myr — Leu — Lys — Lys — Ala — Leu — Lys — OH
'bede ya CAS
959610-54-9
Fórmula molecular
C47H91N9O8
Be̲xu molecular
910.28
Myristoyl Hexapeptide — 16 relacionados ár nthoni
1.nt'o̲t'e biológicas primarias:
Entrega intracelular ar facilitada ja 'nar mediada ácido graso endocitosis proceso; regulación alza ar KRT1, KRT5 ne KRT14 ar gen expresión promueve queratina síntesis específicamente jar folículo capilar células, prolongando ar fase anágena.
ar agrupación carga secuencia lys — lys mbo ár estructura ar une competitivamente TGF — βR II, inhibiendo ya señales transición nu'bu catágeno.
mejoras simultáneas jar longitud ne densidad pestañas ne cejas ge ya resultados documentados.
AQP — 3 ne filaggrin transcripción ar activan, fortalecimiento ar stratum corneum barrera hidratación (reducción pérdida ar dehe transepidérmica).
producción varios mediadores inflamatorios ar modulada.
2.Transcripción ar gen ar queratina
segmento péptido básico imita ya familya KAP5 yá 8, vinculación ma NF — κB-like sites in the promoter regions of keratin genes.
This rapidly increased keratin synthesis enhances the hair shaft integrity and strength.
3.Extended Anagen Phase
The peptide effectively slows follicular regression, maintaining the anagen state.
Enhancing both length and density of eyelashes and eyebrows is observed, reduced hair shedding being another key effect; longer lasting hair growth is supported.
4.Strengthening the Stratum Corneum Barrier
Myristoyl Hexapeptide-16 binds to GPR40/FFA1 receptors on keratinocyte surfaces, activating the cAMP/PKA pathway, CREB (cAMP Response Element-Binding Protein) specifically being the downstream target; AQP-3 and filaggrin transcription follows as a result.
Increased natural moisturizing factor content is a direct outcome, better stratum corneum hydration function being achieved, a more effective skin barrier formed – transepidermal water loss is subsequently reduced.
Improved skin moisturization, enhanced barrier integrity and the alleviation of dryness and roughness are observed; damaged skin repair is within the scope of what this peptide can achieve.
5.Anti-inflammatory and Antioxidant Effects
Inhibiting various inflammatory signaling pathways (NF-κB being a key pathway) is one of its established effects, and pro-inflammatory cytokines (IL-6, TNF-α among others) are down regulated.
Skin redness, irritation and overall sensitive skin symptoms are mitigated by Myristoyl Hexapeptide-16.
COA
HPLC
MS
