Myristoyl Hexapeptide-23 (trade name SymPeptide® 380) is a synthetic peptide ingredient widely incorporated into various skincare formulations. Broad-spectrum antimicrobial properties, and the more specific inhibition of Propionibacterium acnes, are the two primary aspects for which this ingredient is recognized.
Secuencia
Myr-Ala-Lys-Lys-Leu-Lys-Leu-NH2
'bede ya CAS
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Fórmula molecular
C47H92N10O7
Be̲xu molecular
909.3 g yá mol
Research Of Myristoyl Hexapeptide-23
The modified form of this peptide is created through enlace covalente; a hexapeptide sequence is attached to myristic acid (tetradecanoic acid). The myristoyl moiety itself serves as a hydrophobic lipid chain, increasing the overall hydrophobicity of the peptide.
Skin penetration and subsequent absorption are directly promoted by this property. Engineering the peptide to target certain skin concerns – acne being the prime example, along with all related inflammatory conditions from microbial infections – is part of its design.
Chemically classified as an antimicrobial peptide, the additional anti-inflammatory and ‘repairing’ functions it exhibits go beyond simple bacterial killing.
Myristoyl Hexapeptide-23 demonstrates said broad spectrum activity, hne. acnes being one of the most effectively inhibited bacteria.
Propionibacterium acnes lives deep within hair follicles and pores, surface independent, relying on sebum, small cellular debris and near constant metabolic byproducts of the surrounding skin as both an energy source and various nutrients.
Overactive sebaceous glands lead to increased (or at least temporarily uncontrolled) production of sebum; follicle blockage follows. Ar bacteria gem'bu̲ multiplica, libera numerosas proteínas – descompone ar sebo ne ga̲tho te̲ni, tx'u̲tho ne metabólicamente daña ya 'mui Jot'i ar folículo.
Multiplicación ngut'a causa ga̲tho ya nthädi inflamatorias mencionadas ma 'met'o mi; folliculitis, acné hne ngatho, etc..
'bu̲'bya, Myristoyl Hexapéptido — 23 ar gi japu̲'be̲fi jar productos hñeti ar piel pa grasa, piel propensa ja ar acné.
datos da 'mui públicamente pa apoyar wa refutar ár eficacia jar japi ar acné ne ga̲tho ya nkohi relacionadas, wat'i, Tobe carece.
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