Other Names Of Argireline：Notably,Argireline is also known as Acetyl Hexapeptide-8 (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) and acetyl hexapeptide 3
Argireline Definition：Specifically,Argireline is a synthetic peptide whose sequence is derived from the N-terminus region of SNAP-25 protein.
What Does Argireline Do:Generally,Argireline has a similar mechanism of action to botulinum toxin(Botox in a bottle), achieving anti-aging and reducing wrinkles effects by inhibiting the release of neurotransmitter at the neuromuscular junctions. As a common cosmetic bioactive peptide,clinical studies have shown that Argireline can reduce skin wrinkle depth, improve skin elasticity, and increase hydration.
Sequence
Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2
CAS Number
616204-22-9
Molecular Formula
C34H60N14O12S
Molecular Weight
889 g/mol
Argireline Related Research
What Is Argireline
Argireline was developed as a breakthrough topical alternative to botulinum toxin. However, unlike botulinum toxin (“Botox in a bottle”), which requires subcutaneous injection, Argireline works by topical application to the epidermis, thereby avoiding the risks associated with subcutaneous injections.
At its core, Argireline interferes with the neurotransmitter release by targeting the SNARE complex (soluble NSF attachment protein receptor),which is essential for docking acetylcholine containing vesicles.Through this mechanism, it disrupts the SNARE complex’s formation and stability, thereby inhibiting neurotransmitter release.
Building on this mechanism, notably, scientists modeled Argireline on the N-terminus structure of the SNAP-25 protein . It competes with SNAP-25 for binding to vesicle-associated membrane protein (VAMP/synaptobrevin).This peptide technology disrupts the formation of the SNARE complex, thereby inhibiting neuronal exocytosis [1].
Argireline Benefits：
Argireline offers good tolerance and non-invasiveness.Specifically,the main benefits include:
1.Reduction of Facial Muscle Contraction
Argireline minimizes the appearance of expression lines(like forehead wrinkles and crow’s feet) by inhibiting acetylcholine release during exocytosis, which prevents muscle contraction. For example,clinical Studies have shown that 10% argireline serum can reduce wrinkle depth[2] by 30% after 30 days in vivo.
2.Improvement in Skin Texture and Smoothness
Clinical studies have shown that applying a formulation containing 10% acetyl hexapeptide-8 to facial skin daily for 20 days can slightly reduce skin roughness and minimizes transepidermal water loss (TEWL) [3] .Furthermore,after 4 weeks, wrinkle depth was reduced by 49% [4] .
3.Scar and Blemish Improvement
Equally importantly, in a clinical trial with 26 scar patients, topical Argireline gel demonstrated:
- Skin elasticity in the treated area increased significantly.
- Hydration levels decreased slightly
- Sebum production in the scar area decreased significantly relative to the surrounding area.
Most notably, before and after treatment photos showed significant improvement in scars caused by surgical interventions related to cancer treatment, cyst removal, or mole removal.
Conclusion
Collectively,Argireline is a scientifically validated bioactive peptide with a clear mechanism of action. By mimicking the pathway of action of botulinum toxin(“Botox in a bottle”), it can be applied topically,safely and conveniently to gently relax muscle contraction, effectively reducing expression lines and improving skin texture [5] .
COA
HPLC
MS
Article/Literature Citation Notes
The purpose of quoting the scientist and professor's article is to acknowledge, recognise and applaud the exhaustive development work that has been done to undertake this peptide research. The scientist does not in any way support or advocate the purchase, sale or use of this product for any reason, and MOL Changes has no affiliation or relationship, implied or otherwise, with the scientist.
warning
These products are intended for scientific purposes only for in vitro research and are not to be used for human, animal or unethical experiments, in vitro research (Latin: in glass) is conducted in vitro. These products are not drugs and are not approved by the Food and Drug Administration in any country for the prevention, treatment or cure of any medical condition, disease or illness. The introduction of this product into humans or animals in any form is strictly prohibited by law.
Business Policy
MOL Changes does not sell to individuals, but only provides services for scientific research purposes to scientific research institutions, pharmaceutical companies, higher education institutions in the field of biology, cosmetics institutions, and scientific research reagent brands.
