Chonluten, o lo'o i ai le fa'asologa o le amino acid H-Glu-Asp-Gly-OH, ose peptide olaola. O aʻafiaga o le immunomodulatory ma gaioiga faʻamaʻi e faʻamaonia lelei mo lenei peptide.
O lona amataga o se vaega la'ititi e fa'ata'ita'iina vaega taua o polotini lapopo'a e mafai ai ona fa'atatauina ma'oti o nisi ituaiga sela.; tulaga ese le aoga i lenei tulaga e sili atu nai lo le polotini matua lava ia.
O suʻesuʻega ua faʻaalia ai Chonluten e taofiofia tumo necrosis vaega (TNF) gaosiga i totonu monocytes fa'aalia i siama fa'amalama lipopolysaccharides (LPS) (in vitro), matua fa'aumatiaina vave tali inflammatory.
Fa'aoga lelei a fa'ailoga intracellular auala e fesoʻotaʻi ma faʻasalalauga faʻamaʻi o le masini muamua; fa'aitiitiga fa'atupu fa'atupu fa'atupu fa'atupu fa'ama'i e mulimuli mai.
Ua fa'atūina se fa'aaliga le lelei, fa'atapula'a uma le malosi ma le umi o so'o se fa'a'a'ala e tu'uina atu – o le tele o le faaleagaina o le tino o le taunuuga mulimuli lea na vaaia e aunoa ma sea tulafono faatonutonu.
Toe faaleleia ma puipuia epithelial manava sela, e ala i le faʻaitiitia o va i totonu ole sela, o le isi gafatia e fa'aalia e Chonluten; e taua tele le tausiga o le epithelial integrity.
E fa'aitiitia le fa'aogaina o mea fa'ama'i ma mea leaga, faʻavaveina le faʻaleleia o mucosal.
Aotelega, o mea uma o lo'o ta'ua i luga ua avea ai Chonluten ma sui tauva mo togafitiga fa'avae i le lumana'i.
Fa'asologa
H-Glu-Asp-Gly-OH
Numera CAS
/
Fuafua mole
C11H17N3O8
Molecular Weight
319.27
Suʻesuʻega ole Chonluten Peptide
1.Anti-inflammatory Factor Suppression
Ole su'esu'ega sili lea ona fua sa'o.
O le malosi o le fa'aosoina o le tino o le mea lea e mafua ai le mumū; fa'aauau pea po'o le fa'atupu fa'atupuina o mea fa'a-fala'au fa'apea e fa'aauau pea le faagasologa.
Fa'ailoga i totonu o le tino (e pei ona taua i luga) o le mea lea e galue ai Chonluten.
Ala autu, NF-κB o le faʻataʻitaʻiga sili, ua taofia.
mitogen-activated protein kinase/MAPK e mafai foi ona aafia ai.
O le taofiofia o nei mea o loʻo tumau pea, ia te a'u lava, o le pito sili ona taua ma le taimi nei e le faʻamaoniaina o le gaioiga faʻamaʻi a Chonluten.
2.Fa'aleleia ma le Fa'aleleia o le Fa'atonuga o le Epithelial Barrier
O suʻesuʻega o loʻo faʻaalia ai Chonluten faʻapitoa sela epithelial.
Fa'alauiloaina o le fa'aaliga ma le fa'aopoopoina lelei o polotini autu i totonu so'oga fufusi o lona faiga autu.
O le faʻamalosia o nei fesoʻotaʻiga faʻavae e matua faʻaitiitia ai le epithelial fe'avea'i; poloka lelei o le ulu atu i le trans-epithelial o pathogens, allergens, ma o mea leaga eseese o se taunuuga tuusao.
I le taimi e tasi, e fa'aosoina le femalaga'iga ma le fa'ateleina o sela epithelial, fesoasoani i le vave fa'aleleia o so'o se pa mucosal na fa'aleagaina muamua i le mumū, fa'ama'i, po'o manu'a fa'aletino faigofie.
O lenei gaioiga e faʻapipiʻi ai ona aafiaga anti-inflammatory – o le pa fa'amalosia lava ia e fa'aitiitia ai fa'ama'i fa'aosoina i fafo, a o le laititi, sili atu pulea fulafula mafai ai mo (atili) toe faaleleia; ua faia se taamilosaga mama.
3.Fa'alelei o Mama ma Tulafono Fa'atonu Manava
O le Chonluten o loʻo faʻaalia ai le folafolaga faʻapitoa i le togafitia o faʻamaʻi faʻamaʻi manava.
Bronchitis, ituaiga eseese o le sela, ma COPD o lo'o i totonu uma o lona vaega e mafai ona aoga.
Fa'aitiitia le mumū faifaipea po'o le fa'asolosolo faifai pea ma fa'amalosi le tino mama e fa'aleleia, o le mea lea e o'o atu ai i le fa'aleleia atili o vaega uma o le tino.
COA
HPLC
MS
