Cortagen ari tetrapeptide, kunyanya Ala-Glu-Asp-Pro, nhengo yemhuri yeKhavinson peptide. Tsvakurudzo yakadzama munhengo dzakasiyana-siyana – thymus, pineal gland, cerebral cortex kungotaura vashoma – zvaita kuti masayendisiti aparadzanise nhevedzano yezvinyorwa; Cortagen kuve mumwe weavo vakanyanya kudzidza.
Potent, matissue-specific biological regulatory mabasa ane Cortagen. Precise modulation of gene expression (epigenetically kana ndikarangarira nemazvo) ndiyo nzira yayo yekutanga yekuita.
Cortagen pachayo chinhu chebioactive chinotaridzwa kubva pakati penheyo system zvinyorwa. Kuenderera mberi optimization uye rakatevera kuyedza basa rakasundira kuumbwa kwayo kune chaiyo peptide inotangwa yenheyo system..
A chokwadi bioregulator, neuroprotective uye geroprotective mhedzisiro inoonekwa. Epigenetic reprogramming yemasero ndiyo iri pasi pezvibatsiro izvi – kuderera kwakabatana nezera mukutaura kwemajini kunogona kusundirwa kumashure, cellular 'epigenetic age’ kugadziridzwa kune wechidiki.
Anti-kuchembera mhedzisiro inowanikwa kuburikidza neiyi yakawanda-system, multi-chinangwa synergistic chiito.
Kuwedzera neuroprotection uye neurorepair mukati meCentral Nervous System (CNS), pamwe chete nebasa rekuziva, zvinoonekwa.
Immune system uye kudzivirira kwemoyo nemoyo zviri kuongororwa zvakare.
Kutevedzana
Ala-Glu-Asp-Pro
CAS
/
Molecular Formula
C17H26N4O9
Molecular Weight
430.17 g/mol
Cortagen Inoenderana Tsvagiridzo
1.Epigenetic Reprogramming:
Kugona kwaCortagen kwakasarudzika munzvimbo iyi ndiko kutariswa kwebasa rakawanda razvino.
Abnormal DNA uye histone kuchinjwa kutaura kunowedzera nekufamba kwenguva muvanhu vakura; inokuvadza gene basa rinowedzerwa, kuchembera kwakawedzera.
Cortagen inodyidzana ne chromatin complexes ataurwa pamusoro apa, kusundira nyika dzakatsauka kudzokera kune zvimwe 'zvakajairika’ zvimwe.
Kudzoreredza yakambotaurwa gene kutaura kuderera ndiko kupera kwezvese zvakaitwa naCortagen – biological process yekuchembera, uye zviratidzo zvese zvidiki kana zvihombe zvavanoburitsa, vakadzoserwa shure.
Neuroprotection uye CNS kuzvimba (microglial kana kuti zvimwe) chikamu cheiyo biological reversion.
Uyu murairo unopa neurons ine yakagadzikana uye yakanaka microenvironment yekurarama; inomiririra kuratidzwa kwakakosha kweiyo neuroprotective basa.
2.Kukurudzira Neural Repair uye Functional Recovery:
Zvidzidzo zvemhando yemhuka zvakaratidza kuti Cortagen inoderedza kwakasiyana-siyana kwekukuvara kwehuropi sequelae, uye kumhanyisa kwakananga kweNeural functional recovery ndeimwe yemhedzisiro yayo.
Modulating epigenetic regulation ndiyo nzira yazvinoita izvi – activating chaiyo gene zvirongwa zvakabatana neural plasticity, axonal regeneration, uye myelin kuumbwa.
Iyo yakagadziridzwa cellular microenvironment mukati menzvimbo dzakakanganisika ndiko kuitika kwemuviri kweichi chiitiko; neuronal kuzvigadzirisa uye kuberekwa patsva kunotevera semhedzisiro yakananga.
3.Rutsigiro rusina kunanga rweMwoyo uye Immune Systems:
Iyi epigenetic reprogramming uye inotevera 'rejuvenation’ yegene expression ndiyo inobvumidza izvi zvinotsigira.
Iwo matsinga uye immune system anochengetedza padhuze bidirectional kutaurirana, kugadzikana mune yakambotaurwa neural microenvironment iri chikamu chikuru chekubudirira immune homeostasis; zvese zvekunze zvinonetsa (chirwere chakabatanidzwa) vari buffer.
Imwezve systemic anti-kuchembera uye homeostasis inodzora mhedzisiro inogadziriswa neCortagen.
Multi-system mabhenefiti ndiwo mhedzisiro – nhengo dzepakati dzinodzorwa, uye kushanda kwemuviri wose kunovandudzwa.
COA
HPLC
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