Pancragen is bioactive synthetic peptide inoumbwa nemaamino acids.
Tsvagiridzo mupancreatic basa yakaita kuti masayendisiti awane a hormone-sechinhu chinoshanda mukati mepancreatic extracts; kukurudzira pancreas pachayo kuve iyo yekutanga inocherechedzwa maitiro.
Mamiriro chaiwo ehomoni iyi pakutanga akanga asina kujeka.
Kufambira mberi mu molecular biology uye gare gare peptide synthesis tekinoroji yakabvumira kudzokorora kwayo chaiko – kuenderera mberi nekugonesa uye kwakanangwa kugadziridzwa kwechimedu chepakati kubva kune chepakutanga chakabudiswa chiri nzira iyo Pancragen yakagadziriswa..
Post-synthesis, kukosha kwekutsvakurudza kwekiriniki kwakakonzerwa nazvo.
Kuvandudza pancreatic tishu kugadzikana, kukurudzira kugadzirisa, uye kudzora metabolic homeostasis ndiyo yakanyatso kunyorwa mabhenefiti.
Broad anti-inflammatory uye zvinodzivirira zvinoonekwawo mukati mechiropa, itsvo, nervous system nedzimwe nhengo.
Kutevedzana
H2N-Lys-Glu-Asp-Trp-OH
Nhamba yeCAS
/
Molecular Formula
C26H36N6O9
Molecular Weight
576.607
Tsvakurudzo yePancragen Peptide
1.Kudzivirirwa uye Kuberekwazve kwe Pancreatic β-Masero
Kupera kwemaseru aya ndiyo yakakosha pathological factor in chirwere cheshuga.
Kutevedzera endogenous kukura zvinhu kana masaini ekupona, inhibition yeapoptosis ndiyo nzira yakakosha; kudzivirira (kwekanguva) beta masero uye kugadzira inotsigira microenvironment yekuvandudzwa kwesero.
Yakagadzikana mazinga eglucose eropa anochengetwa, zvisina kunanga kuburikidza nekuvandudza peripheral tissue insulin sensitivity – kuderedza zvakasiyana-siyana zve insulin kuramba uye kuwedzera mitochondrial basa.
Pancragen inomutsa idzo dzakambotaurwa nzira dzekupona (PI3K/Act uye MAPK/ERK).
Kutanga nzira dzeapoptotic pasi pekurwiswa kwekuputika kunobudirira kudziviswa.
Miedzo yemakiriniki parizvino iri kuongorora yechokwadi cellular regeneration sepoindi yekupedzisira.
Kukurudzira kupatsanurwa uye kuwanda kweanenge mamwe masero, zvakasanganiswa neyakambotaurwa microenvironment, inomiririra shanduko yakakosha yekuenderera mberi kwechirwere cheshuga.
2.Metabolic Regulation (sepamusoro)
Systemic kunatsiridza insulin senitivity inoonekwa mumhando dzemhuka.
Cytoprotection inoderedza hepatic uye adipose tissue kusingaperi kuzvimba.
Yakananga uye isina kunanga mhedzisiro pa insulin receptor uye basa rekutakura zvose chikamu chekuvandudzwa kwese kwe insulin senitivity.
Antioxidant uye anti-kuzvimba mhedzisiro yePancragen ndeyekukosha kwekutsvagisa.
Neuropathy uye metabolic syndrome type kukuvara, kana chero chirwere chine chekuita nazvo oxidative stress, inogona uye inofanirwa kubatsirwa kubva kuPancragen therapeutic application.
COA
HPLC
MS
