Myristoyl Pentapeptide-8 is a bioactive cosmetic peptide synthesized through the chemical modification of a natural signaling sequence.
Its unique hair growth and various cosmetic functions are attributed to a specific conserved pentapeptide fragment, Lys-Thr-Thr-Lys-Ser, derived from the α1 chain of type I procollagen.
Its defining action is to stimulate dermal фібробласти , thereby initiating a subsequent cascade that promotes the synthesis of both колаген і фібронектин.
Проте, rapid enzymatic degradation presents a significant barrier to its practical therapeutic application.
To overcome this, researchers have modified the peptide by conjugating it with a fatty acid chain. This modification preserves the original charge characteristics while greatly improving compatibility with the intercellular lipids з роговий шар шкіри.
Отже, the modification extends the peptide’s half-life and significantly improves its трансдермальний penetration efficiency.
In summary, this peptide achieves potent cosmetic efficacy, securing its place in premium skincare formulations.
Послідовність
Lys-Thr-Thr-Lys-Ser (KTTKS)
Номер CAS
2305730-23-6
Молекулярна формула
C37H71N7O10
Молекулярна маса
774.01
Myristoyl Pentapeptide-8 Related Research
1.Dermal-Epidermal Junction and Skin Structure Enhancement
Experimental evidence shows that Myristoyl Pentapeptide-8 mimics the biological signaling of ламінін-5, thereby reinforcing and repairing the structure and function of the dermal-epidermal junction (ВОДА).
It stimulates dermal fibroblasts to synthesize and assemble key базальна мембрана components, including collagen I, III, і еластин.
The end result is the fortification of the skin’s internal architecture, which reduces the depth and number of wrinkles (with loss of elasticity being a major contributing factor), leading to firmer and overall healthier-looking skin.
It also positively influences keratinocyte differentiation and keratin polymerization.
2.Direct Promotion of Dermal Collagen Regeneration
As mentioned, the peptide binds to and activates the LDL receptor-related protein (LRP/LDL receptor-related protein) on the fibroblast surface, triggering the aforementioned effects.
3.Regulation of the Hair Follicle Growth Cycle
Myristoyl Pentapeptide-8 activates the β-catenin/LEF1 signaling pathway within dermal papilla cells.
This action inhibits BMP4-induced regression signals, thereby directly prolonging the anagen (зростання) phase of the hair follicle.
Experimental evidence from a mouse model of андрогенна алопеція supports this mechanism; continuous application for 21 days led to synchronized increases in eyelash, eyebrow, and scalp hair densities.
4.Enhancement of Skin Barrier Function and Antioxidant Activity
The unique structure of Myristoyl Pentapeptide-8 provides enhanced stability, with the myristoyl moiety itself inducing steric hindrance.
It lowers the activation threshold for inflammatory factors, thereby improving the skin’s resilience to environmental stress.
It supports normal epidermal cell differentiation and its metabolic cycle.
Крім того, it promotes the synthesis of key lipids (в тому числі ceramides) within the stratum corneum, ultimately reinforcing the physical barrier and creating an optimal skin environment.
The long-term result is improved skin stability.
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